Abstract: Communication between the surface and a downhole location, such as a bottomhole assembly and/or an RSS is performed by electromagnetic downlink. Electromagnetic signals are transmitted from the surface through the formation at a frequency of 8 Hz or greater. Electromagnetic signals are transmitted and received while drilling or during drilling activities. In this manner, information and instructions may be transmitted to the BHA while drilling.

Abstract: Embodiments are disclosed for crash detection on one or more mobile devices (e.g., smartwatch and/or smartphone. In some embodiments, a method comprises: detecting a crash event on a crash device; extracting multimodal features from sensor data generated by multiple sensing modalities of the crash device; computing a plurality of crash decisions based on a plurality of machine learning models applied to the multimodal features, wherein at least one multimodal feature is a rotation rate about a mean axis of rotation; and determining that a severe vehicle crash has occurred involving the crash device based on the plurality of crash decisions and a severity model.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Apparatuses and methods can be related to supplementing AI processing in memory. An accelerator and/or a host can perform AI processing. Some of the operations comprising the AI processing can be performed by a memory device instead of by an accelerator and/or a host. The memory device can perform AI processing in conjunction with the host and/or accelerator.

Abstract: A method includes receiving a signal having a telemetry portion and a noise portion. The method may also include identifying one or more harmonic frequencies in the signal. The method may also include determining whether the one or more harmonic frequencies are in a predetermined frequency band. The method may also include determining whether a signal-to-noise ratio (SNR) of the signal is below a predetermined SNR threshold. The method may also include generating one or more notifications in response to the determination whether the one or more harmonic frequencies are in the predetermined frequency band and the determination whether the SNR is below the predetermined SNR threshold.

Abstract: In one embodiment of the present disclosure, a composition for producing a vanadium electrolyte includes a vanadium compound and an ion solution containing vanadium ions and hydrogen ions. In another embodiment, a method for producing a vanadium electrolyte includes obtaining a vanadium compound, and mixing the vanadium compound with an ion solution containing vanadium ions and hydrogen ions.

Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.

Abstract: Disclosed is a medication delivery system comprising: a container for a medium: a plunger disposed in the container; and a lead screw axially fixed with respect to the container and in threaded engagement with the plunger, where the lead screw is disposed inside of the container, and the rotation of the lead screw causes axial displacement of the plunger with respect to the container. A patch pump comprising the medication delivery system and a medicament delivery device comprising the medication delivery system are also disclosed.

Abstract: Embodiments of systems and methods for implementing data sovereignty safeguards in a distributed services network architecture are disclosed. Embodiments of a distributed services system may have a number of distributed nodes that each implements a set of services. When a user requests a service at a particular node of a distributed services system, the node is configured to determine if that node is not (or is) data sovereign for a region associated with the user. If the node is not data sovereign for the user's region, the user may be directed to a corresponding service at a node of the distributed service system that is data sovereign for the user's region.

Abstract: An apparatus, a method, and a system. The method includes implementing an erase operation on a deck of a superblock, block or subblock of a three-dimensional (3D) non-volatile memory device to obtain an erased deck; applying a dummy read pulse to one or more wordlines (WLs) of a to-be-read deck of the superblock, block or subblock; and implementing, after application of the dummy read pulse, a read operation on one or more memory cells corresponding to the one or more WLs to read data from the one or more memory cells.

Abstract: An apparatus and method are provided for harvesting tall growing crops, such as fresh fruit bunches from oil palm trees.

Abstract: This invention relates to anti-CD70 antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are ?CD70 antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the ?CD70 antibodies of the invention are conjugated to one or more toxins. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, including therapeutic, diagnostic, and other biotechnology uses.

Abstract: Examples include a method of predictive rate limiting for performing services requested by a client in a cloud computing system. The method includes receiving a request from a client for one of a plurality of services to be performed, the client belonging to an organization; and determining a current threshold for the organization by applying a real time data model and a historical data model, the real time data model generating a first threshold at least in part by determining a number of requests received from the organization over a first preceding period of time; the historical data model generating a second threshold, the historical data model being generated by applying a machine learning model to historical data stored during processing of previous requests for the plurality of services from the organization over a second preceding period of time, the current threshold being the average of the first threshold and the second threshold.

Abstract: A trigger-responsive immune-inactivating signaling polypeptide disclosed herein can include a modulating domain and an immune-inactivating moiety, such as a dominant negative signaling moiety or constitutively active signaling moiety. A modulating domain can be characterized by an ability to adopt a first state and a second state, and to transition between the first state and the second state when exposed to a trigger. When the modulating domain is in its first state, the immune-inactivating signaling moiety can be inhibited, and when the modulating domain is in its second state, the inhibition can be relieved. Further disclosed herein are compositions for the delivery of a trigger-responsive immune-inactivating signaling polypeptide. Also, methods for using a trigger-responsive immune-inactivating signaling polypeptide, including to regulate an activity of immune system cells, are disclosed.

Abstract: Provided herein are methods of administering estrogen receptor antagonists for use in treatment of cancer. In some embodiments, estrogen receptor antagonists provided herein are tetrahydro pyrido[3,4-b]indole compounds. In some embodiments, provided antagonists are complete estrogen receptor antagonists.

Abstract: Provided herein are methods of administering estrogen receptor antagonists for use in treatment of cancer. In some embodiments, estrogen receptor antagonists provided herein are tetrahydro pyrido[3,4-b] indole compounds. In some embodiments, provided antagonists are complete estrogen receptor antagonists.

Abstract: Examples include a method of predictive rate limiting for performing services requested by a client in a cloud computing system. The method includes receiving a request from a client for one of a plurality of services to be performed, the client belonging to an organization; and determining a current threshold for the organization by applying a real time data model and a historical data model, the real time data model generating a first threshold at least in part by determining a number of requests received from the organization over a first preceding period of time; the historical data model generating a second threshold, the historical data model being generated by applying a machine learning model to historical data stored during processing of previous requests for the plurality of services from the organization over a second preceding period of time, the current threshold being the average of the first threshold and the second threshold.

Abstract: Configuring a hardware system includes providing a first data representative of a first assignment of a multitude of wires to a multitude of physical connections between a multitude of logic circuits of the hardware system, and transforming the first data into a second data representative of a second assignment of the multitude of wires to the multitude of physical connections. The transforming includes calculating a multitude of latencies each associated with a selected one of the multitude of wires, and assigning a first subset of the multitude of wires to at least one of the multitude of physical connections in accordance with a first improvement goal. The transforming causes the value of each one of the multitude of latencies that are associated with the first subset to be less than or equal to the first improvement goal, when the second data is used to configure the hardware system.

Abstract: A place and route technique is provided for a programmable logic device to optimize a delay difference between a clock to out path and a clock out path.

Abstract: An automated 450 mm wafer sample stage for ellipsometers. The sample stage includes a plurality of sample support pins and sample guides for precision positioning. The sample support pins and sample guides may be mounted on the same holding arm which is electronically controlled by a computer user interface. The sample support pins and sample guides are raised to a predefined height to allow sufficient space for a 450 mm be transferred with a vacuum wand onto the support pins and position guides. By electronically lowering the support pins below the surface of the sample stage plate, the 450 mm wafer is placed on the ellipsometer's sample stage without any stress to the wafer surface.