Patents by Inventor Robert A. Galemmo, Jr.

Robert A. Galemmo, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Pyrimidines and Uses Thereof
    Publication number: 20230146395
    Abstract: The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases treatable by inhibition of PIKfyve and/or PI3 kinases. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment of neurological diseases using such compounds.
    Type: Application
    Filed: March 8, 2021
    Publication date: May 11, 2023
    Applicant: Verge Analytics, Inc.
    Inventors: Mark D. Rosen, Robert A. Galemmo, Jr., Weiling Liang, Irene Y. Choi, Brian Kopec, Jane Rhodes
  • KETONE INHIBITORS OF LYSINE GINGIPAIN
    Publication number: 20230142714
    Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
    Type: Application
    Filed: May 9, 2022
    Publication date: May 11, 2023
    Applicant: CORTEXYME, INC.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, JR., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
  • Substituted Pyrazolo-Pyrimidines and Uses Thereof
    Publication number: 20230133203
    Abstract: The present disclosure provides compounds that are inhibitors of PIKfyve kinases useful for the treatment of neurological diseases treatable by inhibition of PIKfyve. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment using such compounds.
    Type: Application
    Filed: January 12, 2021
    Publication date: May 4, 2023
    Applicant: Verge Analytics, Inc.
    Inventors: Mark D. Rosen, Robert A. Galemmo, JR., Weiling Liang, Brian Kopec, Irene Y. Choi, Jane Rhodes
  • Fused Tricyclic Heterocyclic Compounds and Uses Thereof
    Publication number: 20230038929
    Abstract: The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases that are treatable by inhibition of PIKfyve. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment using such compounds.
    Type: Application
    Filed: December 4, 2020
    Publication date: February 9, 2023
    Applicant: Verge Analytics, Inc.
    Inventors: Mark D. Rosen, Robert A. Galemmo, JR., William J. Guilford, Weiling Liang, Irene Y. Choi, Bryan Kopek, Jane Rhodes
  • Ketone inhibitors of lysine gingipain
    Patent number: 11325884
    Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: May 10, 2022
    Assignee: CORTEXYME, INC.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, Jr., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
  • BIOORTHOGONAL COMPOSITIONS
    Publication number: 20220105191
    Abstract: The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Inventors: Jose MEJIA ONETO, Robert GALEMMO, JR.
  • AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF
    Publication number: 20210340105
    Abstract: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: July 8, 2021
    Publication date: November 4, 2021
    Applicant: Cortexyme, Inc.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, JR., Casey C. Lynch
  • Aminopyridine compounds and methods for the preparation and use thereof
    Patent number: 11059786
    Abstract: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: July 13, 2021
    Assignee: CORTEXYME, INC.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, Jr., Casey C. Lynch
  • KETONE INHIBITORS OF LYSINE GINGIPAIN
    Publication number: 20210053908
    Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
    Type: Application
    Filed: June 11, 2020
    Publication date: February 25, 2021
    Applicant: CORTEXYME, INC.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, JR., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
  • BIOORTHOGONAL COMPOSITIONS
    Publication number: 20210015932
    Abstract: The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 21, 2021
    Inventors: Jose MEJIA ONETO, Robert GALEMMO, JR.
  • Bioorthogonal compositions
    Patent number: 10828373
    Abstract: The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: November 10, 2020
    Assignee: Tambo, Inc.
    Inventors: Jose Mejia Oneto, Robert Galemmo, Jr.
  • Ketone inhibitors of lysine gingipain
    Patent number: 10730826
    Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: August 4, 2020
    Assignee: CORTEXYME, INC.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, Jr., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
  • AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF
    Publication number: 20200148642
    Abstract: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: November 8, 2019
    Publication date: May 14, 2020
    Applicant: Cortexyme, Inc.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, JR., Casey C. Lynch
  • KETONE INHIBITORS OF LYSINE GINGIPAIN
    Publication number: 20190210960
    Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Applicant: CORTEXYME, INC.
    Inventors: Andrei W. Konradi, Robert A. Galemmo, JR., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
  • BIOORTHOGONAL COMPOSITIONS
    Publication number: 20180360979
    Abstract: The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 20, 2018
    Inventors: Jose MEJIA ONETO, Robert GALEMMO, JR.
  • Triazolopyridazine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof
    Patent number: 9187484
    Abstract: Provided are novel LRRK2 kinase inhibitors and methods of treating disease states using these inhibitors. Examples of LRRK2 kinase inhibitors are compounds of the formula: or derivatives thereof. An example is 1-(piperidin-1-yl)-2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butan-1-one. Particular uses include treating neurodegenerative diseases, cancer, autoimmune diseases and leprosy.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: November 17, 2015
    Assignees: Southern Research Institute, The UAB Research Foundation
    Inventors: Robert A. Galemmo, Jr., Andrew B. West, Joseph A. Maddry, Subramaniam Ananthan, Ashish Kumar Pathak, Jacob Valiyaveettil
  • TRIAZOLOPYRIDAZINE COMPOUNDS, USE AS INHIBITORS OF THE KINASE LRRK2, AND METHODS FOR PREPARATION THEREOF
    Publication number: 20130296298
    Abstract: The present invention provides novel LRRK2 kinase inhibitors and methods of treating disease states using these inhibitors.
    Type: Application
    Filed: May 2, 2013
    Publication date: November 7, 2013
    Applicants: THE UAB RESEARCH FOUNDATION, Southern Research Institute
    Inventors: Robert A. Galemmo, JR., Andrew B. West, Joseph A. Maddry, Subramaniam Ananthan, Ashish Kumar Pathak, Jacob Valiyaveettil
  • ARYL SULPHONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20120245137
    Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity, are disclosed. Specifically, a series of compounds containing aryl sulphone derivatives, as exemplified by Formula (I).
    Type: Application
    Filed: September 17, 2010
    Publication date: September 27, 2012
    Applicant: Zalicus Pharmaceuticals Ltd.
    Inventors: Hassan A. Pajouhesh, Robert Galemmo, JR., Richard Holland, Yuanxi Zhou, Yongbao Zhu, Eric Simonson, Navjot Chahal, Mike Grimwood
  • Inhibitors of Polo-Like Kinase
    Publication number: 20120115848
    Abstract: The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
    Type: Application
    Filed: October 6, 2011
    Publication date: May 10, 2012
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Robert A. Galemmo, JR., Dean Richard Artis, I, Xiaocong Michael Ye, Danielle L. Aubele, Anh P. Truong, Simeon Bowers, Roy K. Hom, Yong-Liang Zhu, R. Jeffrey Neitz, Jennifer Sealy, Marc Adler, Paul Beroza, John P. Anderson
  • N-substituted tricyclic 1-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
    Patent number: 7795440
    Abstract: The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 14, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Chih Yung Ho, Bengt Anders Brunmark, Stuart Emanuel, Robert A. Galemmo, Jr., Dana L. Johnson, Donald W. Ludovici, Umar Maharoof, Jay M. Mei, Jan L. Sechler, Eric D. Strobel, Robert W. Tuman, Hwa Kwo Yen