Patents by Inventor Robert B. Garland

Robert B. Garland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5552431
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: September 3, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano
  • Peptide mimics useful as platelet aggregation inhibitors
    Patent number: 5550159
    Abstract: This invention relates to compounds having the following formula ##STR1## or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: August 27, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Robert B. Garland, Masateru Miyano, Joseph G. Rico, Thomas E. Rogers, Jeffery A. Zablocki
  • Platelet activating factor antagonists: imidazopyridine indoles
    Patent number: 5486525
    Abstract: The present invention relates to compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: January 23, 1996
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, Jr., Steven K. Davidsen, Michael L. Curtin, H. Robin Heyman, George S. Sheppard, Lianhong Xu, George M. Carrera, Jr., Robert B. Garland
  • Phenyl amidines derivatives useful as platelet aggregation inhibitors
    Patent number: 5481021
    Abstract: This invention relates to phenyl amidine derivatives having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 2, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki, Lori A. Schretzman
  • Peptide mimics useful as platelet aggregation inhibitors
    Patent number: 5453440
    Abstract: This invention relates to compounds having the following formula ##STR1## or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: September 26, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Robert B. Garland, Masateru Miyano, Joseph G. Rico, Thomas E. Rogers, Jeffery A. Zablocki
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5424334
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: June 13, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5220050
    Abstract: This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: June 15, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Dudley E. McMackins, Joseph G. Rico, Foe S. Tjoeng, Mihaly V. Toth, Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki
  • Methods for the use of thromboxane A.sub.2 antagonists
    Patent number: 5106870
    Abstract: This invention relates to several thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids, pharmaceutical compositions employing them and methods of their use.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: April 21, 1992
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Pyridyl peptide mimetic compounds which are useful platelet-aggregation inhibitors
    Patent number: 5091396
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8,y=0 to 4,W=CH.sub.2 --CH.sub.2 or C.dbd.CH,Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,R=C.sub.1-6 alkyl,Ar=a nitrogen-containing heterocyclic group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: January 7, 1991
    Date of Patent: February 25, 1992
    Assignees: Monsanto Co., G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Steven P. Adams, Robert B. Garland, Masateru Miyano
  • Process for preparing thromboxane A.sub.2 antagonists
    Patent number: 5055582
    Abstract: This invention relates to a process for preparing useful thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)thioxomethyl]hydrazono]ethyl]-1.alpha. ,4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha.,7a.alpha.-4.alpha.,7.alpha.-meth ano-2H-inden-2-ones.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: October 8, 1991
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Indolyl platelet-aggregation inhibitors
    Patent number: 5037808
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8,y=0 to 4,W=CH.sub.2 --CH.sub.2 or CH.dbd.CH,Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,R=C.sub.1-6 alkyl,Ar=a nitrogen-containing heterocyclic group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: April 23, 1990
    Date of Patent: August 6, 1991
    Assignees: Monsanto Co., G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Steven P. Adams, Robert B. Garland, Masateru Miyano
  • Benzopyran intermediates for use in manufacturing thromboxane A.sub.2 antagonists
    Patent number: 4992563
    Abstract: This invention relates to several intermediates useful in preparing thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-1.alpha ., 4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha., 7a.alpha.-4.alpha.,7.alpha.-methano-2H-inden-2-ones.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: February 12, 1991
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Novel methods of manufacturing thromboxane A.sub.2 antagonists
    Patent number: 4992581
    Abstract: This invention relates to several novel methods of manufacturing thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: February 12, 1991
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Thromboxane A.sub.2 antagonists and pharmaceutical compositions thereof
    Patent number: 4973604
    Abstract: This invention relates to several thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids, pharmaceutical compositions employing them and methods of their use.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: November 27, 1990
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Novel intermediates in the manufacture of novel thromboxane A.sub.2 antagonists
    Patent number: 4942256
    Abstract: This invention relates to several novel intermediates useful in the manufacture of thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: July 17, 1990
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic methods of use thereof
    Patent number: 4719220
    Abstract: The present invention provides novel compounds of Formula I ##STR1## which are pharmacologically selectively useful as anti-thrombotic agents with minimal blood pressure lowering activity.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: January 12, 1988
    Assignee: G. D. Searle & Co.
    Inventors: Stevan W. Djuric, Robert B. Garland
  • 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof
    Patent number: 4616034
    Abstract: The present invention provides novel compounds of Formula I ##STR1## which are pharmacologically selectively useful as anti-thrombotic agents with minimal blood pressure lowering activity.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: October 7, 1986
    Assignee: G. D. Searle & Co.
    Inventors: Stevan W. Djuric, Robert B. Garland
  • Method for preparing 5-fluoroprostacyclins
    Patent number: 4611065
    Abstract: This invention relates to a process for preparing 5-fluoroprostacyclins that are useful for the treatment of platelet dysfunction.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: September 9, 1986
    Assignee: G. D. Searle & Co.
    Inventor: Robert B. Garland
  • Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
    Patent number: 4496485
    Abstract: This invention relates to novel diastereomeric 7-O-(substituted acetyl)-4-demethoxydaunomycinones that are useful in the preparation of optically pure 4-demethoxydaunorubicin, a drug used in the treatment of certain cancers.
    Type: Grant
    Filed: November 25, 1983
    Date of Patent: January 29, 1985
    Assignee: G. D. Searle & Co.
    Inventor: Robert B. Garland
  • 11-Amino-11-deoxydaunorubicin and analogs
    Patent number: 4348388
    Abstract: 11-Amino-11-deoxydaunorubicin and analogs represented by the formula: ##STR1## wherein: R is hydrogen, hydroxy or methoxy; R.sub.1 is hydrogen or hydroxy; and the pharmaceutically acceptable salts thereof.The compounds are useful in ameliorating tumor growth.
    Type: Grant
    Filed: April 2, 1980
    Date of Patent: September 7, 1982
    Assignee: G.D. Searle & Co.
    Inventors: Robert B. Garland, Raphael Pappo, Paul B. Sollman