Abstract: A pneumatic hypodermic syringe pole of first and second axially connected hollow tubes joined by a coupling cylinder supporting an axially slidable valve member including a hollow valve stem adapted to sealingly engage opening within the end of a hollow syringe body whose opposite end carries a needle. A plunger within the syringe separates the body interior into a drug injection chamber communicating with the needle and a second chamber capable of receiving gas under pressure for driving the plunger to displace a drug from the injection chamber. The first hollow tube operates as a handle for manual grasping and forms a pressurized gas storage compartment open to the axially displaceable valve member. The syringe is axially shiftable internally of the second hollow tube forming a syringe holder with the valve stem being positioned in the path of movement of the axially displaceable syringe.