Patents by Inventor Robert C. Ladner

Robert C. Ladner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090117130
    Abstract: Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 7, 2009
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams, Maria Grazia De Simoni, Luigi Bergamaschini
  • Publication number: 20090105083
    Abstract: Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second coding region encoding a second immunoglobulin variable domain, and c) a ribosomal binding site disposed between the first and second coding regions for translation of the second polypeptide in a first expression system, wherein the first and second coding regions are in the same translational orientation; (ii) modifying each nucleic acid cassette of the plurality in a single reaction mixture so that it is functional in a second expression system, wherein the first and second region remain physically attached during the modifying; (iii) introducing each modified nucleic acid cassette into a mammalian cell to produce a mixture of transfected cells; and (iv) expressing each modified nucleic acid cassette in the transfected cells.
    Type: Application
    Filed: June 14, 2007
    Publication date: April 23, 2009
    Inventors: Henricus Renerus Hoogenboom, Jurgen Mullberg, Robert C. Ladner
  • Patent number: 7514534
    Abstract: Disclosed are antibodies that interact with a matrix metalloproteases such as MMP-26. Exemplary antibodies inhibit MMP-26 activity. These antibodies can be used, e.g., to treat or prevent metastatic disorders, hyperproliferative disorders, disorders which are characterized by excessive extracellular matrix degradation, and inflammatory disorders.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: April 7, 2009
    Assignee: DYAX Corp.
    Inventors: Daniel T. Dransfield, Kristin Rookey, Robert C. Ladner
  • Publication number: 20090082267
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Application
    Filed: October 30, 2007
    Publication date: March 26, 2009
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams
  • Publication number: 20090062195
    Abstract: Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
    Type: Application
    Filed: October 30, 2007
    Publication date: March 5, 2009
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams, Maria Grazia De Simoni, Luigi Bergamaschini
  • Publication number: 20090036366
    Abstract: This invention provides: novel proteins, which are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and which are capable of inhibiting plasmin; uses of such novel proteins in therapeutic, diagnostic, and clinical methods; and polynucleotides that encode such novel proteins.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 5, 2009
    Applicant: DYAX CORP.
    Inventors: William Markland, Robert C. Ladner
  • Publication number: 20090036365
    Abstract: This invention provides: novel proteins, which are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and which are capable of inhibiting plasmin; uses of such novel proteins in therapeutic, diagnostic, and clinical methods; and polynucleotides that encode such novel proteins.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 5, 2009
    Applicant: DYAX CORP.
    Inventors: William Markland, Robert C. Ladner
  • Publication number: 20090023651
    Abstract: This invention provides: novel proteins, which are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and which are capable of inhibiting plasmin; uses of such novel proteins in therapeutic, diagnostic, and clinical methods; and polynucleotides that encode such novel proteins.
    Type: Application
    Filed: October 31, 2007
    Publication date: January 22, 2009
    Inventors: William Markland, Robert C. Ladner
  • Publication number: 20080260752
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Application
    Filed: November 2, 2007
    Publication date: October 23, 2008
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams
  • Publication number: 20080255025
    Abstract: Proteins including engineered sequences which inhibit proteases are disclosed, including proteins having two or more engineered Kunitz domains, and uses of such proteins.
    Type: Application
    Filed: December 27, 2006
    Publication date: October 16, 2008
    Inventor: Robert C. Ladner
  • Publication number: 20080241127
    Abstract: Methods for isolating antibodies useful as passive immunotherapies are described.
    Type: Application
    Filed: December 13, 2007
    Publication date: October 2, 2008
    Inventors: Henry Blair, Clive R. Wood, Robert C. Ladner
  • Publication number: 20080226655
    Abstract: Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
    Type: Application
    Filed: October 30, 2007
    Publication date: September 18, 2008
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams, Maria Grazia De Simoni, Luigi Bergamaschini
  • Publication number: 20080221031
    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 11, 2008
    Applicant: DYAX CORP.
    Inventors: Henry Blair, Thomas Beck, Robert C. Ladner
  • Publication number: 20080213251
    Abstract: The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.
    Type: Application
    Filed: December 14, 2007
    Publication date: September 4, 2008
    Applicant: DYAX CORP.
    Inventors: Daniel J. Sexton, Andrew Nixon, Anthony Williams, Robert C. Ladner, Qi-Long Wu
  • Publication number: 20080200646
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 21, 2008
    Inventors: Robert C. Ladner, Arthur C. Ley
  • Publication number: 20080188409
    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 7, 2008
    Applicant: DYAX CORP.
    Inventors: Henry Blair, Thomas Beck, Robert C. Ladner
  • Publication number: 20080182283
    Abstract: This invention provides: novel proteins, which are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and which are capable of inhibiting plasmin; uses of such novel proteins in therapeutic, diagnostic, and clinical methods; and polynucleotides that encode such novel proteins.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 31, 2008
    Applicant: DYAX CORP.
    Inventors: William Markland, Robert C. Ladner
  • Publication number: 20080152656
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 26, 2008
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams
  • Publication number: 20080139473
    Abstract: Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 12, 2008
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams, Maria Grazia De Simoni, Luigi Bergamaschini
  • Publication number: 20080131426
    Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 5, 2008
    Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams