Patents by Inventor Robert G. Hofstraat

Robert G. Hofstraat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of budesonide
    Patent number: 5556964
    Abstract: The present invention relates to a novel process for the manufacture of (22 R,S)-16.alpha., 17.alpha.-butylidenedioxy-11.beta., 21-dihydroxypregna-1,4-diene-3,20 dione (I) by reacting 11.beta., 16.alpha., 17.alpha. 21-tetrahydroxypregna-1,4-diene (II) with butanal, CH.sub.3-- CH.sub.2 --CH.sub.2 --CHO, in acetonitrile in presence of p-toluenesulphonic acid as a catalyst.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: September 17, 1996
    Assignee: Aktiebolaget Astra
    Inventors: Robert G. Hofstraat, Petrus H. Raijmakers, Pieter Vrijhof