Patents by Inventor Robert G. Korneluk

Robert G. Korneluk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Patent number: 6107088
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: August 22, 2000
    Assignee: Apoptogen Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • Detection and modulation of IAPS for the diagnosis and treatment of proliferative disease
    Patent number: 6107041
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: August 22, 2000
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • Neuronal apoptosis inhibitor protein, gene sequence and mutations causative of spinal muscular atrophy
    Patent number: 6020127
    Abstract: The gene for the autosomal recessive neurodegenerative disorder Spinal Muscular Atrophy has been mapped to a region of chromosome 5. The gene encodes a protein having homology with apoptosis inhibitor proteins of viruses so that the encoded protein has been labelled as a neuronal apoptosis inhibitor protein (NAIP). A deletion in the (NAIP) domain was identified in persons with Type I, II and III Spinal Muscular Atrophy (SMA) and not in the normal non-SMA population.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: February 1, 2000
    Assignees: The University of Ottawa, Research Development Corp. of Japan
    Inventors: Alex E. MacKenzie, Robert G. Korneluk, Natalie Roy, Mani S. Mahadevan, Michael McLean, Joh-E Ikeda
  • Mammalian IAP antibodies and diagnostic kits
    Patent number: 5919912
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: July 6, 1999
    Assignee: University of Ottawa
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird