Patents by Inventor Robert H. Grubbs

Robert H. Grubbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210017111
    Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification
    Type: Application
    Filed: July 7, 2020
    Publication date: January 21, 2021
    Inventors: Jiaming Li, Chen Xu, Tonia S. Ahmed, Robert H. Grubbs, Brian M. Stoltz
  • Publication number: 20200385360
    Abstract: This invention relates generally to the synthesis of E-macrocycles using stereoretentive ruthenium olefin metathesis catalysts supported by dithioiate ligands. Macrocycles were generated with excellent selectivity (>99% E) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield) from diene starting materials bearing two E-olefins or bearing one E-olefin and one terminal olefin, A variety of rings were constructed, ranging from 12- to 18-membered macrocycles, including the antibiotic recifeiolide. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Application
    Filed: December 4, 2018
    Publication date: December 10, 2020
    Inventors: Tonia S. AHMED, T. Patrick MONTGOMERY, Robert H. GRUBBS
  • Patent number: 10857530
    Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: December 8, 2020
    Assignees: Umicore AG & Co. KG, California Institute of Technology
    Inventors: Adam M. Johns, T. Patrick Montgomery, Tonia S. Ahmed, Robert H. Grubbs, Richard L. Pederson
  • Publication number: 20200377529
    Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 18F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.
    Type: Application
    Filed: August 19, 2020
    Publication date: December 3, 2020
    Inventors: Christopher Martin Waldmann, Anton A. Toutov, Jennifer Marie Murphy, Robert H. Grubbs
  • Publication number: 20200377528
    Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
    Type: Application
    Filed: August 19, 2020
    Publication date: December 3, 2020
    Inventors: Anton A. Toutov, Kerry N. Betz, Andrew M. Romine, Robert H. Grubbs
  • Publication number: 20200373622
    Abstract: Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the ?-position or does not possess a carbon in the ?-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane).
    Type: Application
    Filed: June 10, 2020
    Publication date: November 26, 2020
    Applicants: CALIFORNIA INSTITUTE OF TECHNOLOGY, HONDA MOTOR CO., LTD.
    Inventors: Simon C. JONES, Victoria K. DAVIS, Christopher M. BATES, Nebojsa MOMCILOVIC, Brett M. SAVOIE, Michael A. WEBB, Thomas F. MILLER, III, Robert H. GRUBBS, Christopher BROOKS, Kaoru OMICHI
  • Patent number: 10840504
    Abstract: In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: November 17, 2020
    Assignee: California Institute of Technology
    Inventors: Simon C. Jones, Emmanuelle Despagnet-Ayoub, Brendon McNicholas, Harry B. Gray, Robert H. Grubbs, Danh Ngo
  • Patent number: 10827950
    Abstract: A position sensing apparatus includes a position sensor, a voltage/current detector, and an alarm. The position sensor is coupled to the body part and includes a capsule, and first and second electrodes. The capsule has an interior volume configured to contain a liquid with a first density, and a contact member having a second density different from the first density. The first and second electrodes are fixed to the capsule to define a sensor meridian that is coupled to a tilt angle of the body part, with each electrode having a distal portion in the interior volume of the capsule, and the distal portions being configured to form a circuit with the liquid or the contact member. The voltage/current detector is configured to detect a change in a state of the circuit, and the alarm is configured to respond to the voltage/current detector.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: November 10, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Hyuck Choo, Frank L. Brodie, Robert H. Grubbs
  • Publication number: 20200330970
    Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.
    Type: Application
    Filed: July 2, 2020
    Publication date: October 22, 2020
    Inventors: Adam M. Johns, Jessica R. HERRON, Richard L. PEDERSON, Bryan A. FIAMENGO, Jennifer A. BEERMAN, Tzu-Pin LIN, Crystal K. CHU, Robert H. GRUBBS
  • Patent number: 10799613
    Abstract: The present invention relates to methods of metathesizing olefins using catalysts previously considered to be practically inactive. The present invention further relates to novel photosensitive compositions, their use as photoresists, and methods related to patterning polymer layers on substrates. Further, modifications to the compositions and method provide for an unprecedented functionalization of the compositions, useful for example in the preparation of sensors, drug delivery systems, and tissue scaffolds. The novel compositions and associated methods also provide for the opportunity to prepare 3-dimensional objects which provide new access to critically dimensioned devices, including for example photonic devices.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: October 13, 2020
    Assignee: California Institute of Technology
    Inventors: Raymond Weitekamp, Robert H. Grubbs, Harry A. Atwater, James Fakonas
  • Patent number: 10800797
    Abstract: The present invention includes novel compounds and compositions including heteroaromatic Silicon-Fluoride-Acceptors, which are useful for PET scanning. The present invention further includes a novel method of 18F imaging for PET scanning, the method comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic SiFAs. In one embodiment the invention is practiced in the form of a kit.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: October 13, 2020
    Assignees: California Institute of Technology, The Regents of the University of California
    Inventors: Christopher Martin Waldmann, Anton A. Toutov, Jennifer Marie Murphy, Robert H. Grubbs
  • Patent number: 10792651
    Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 6, 2020
    Assignees: Umicore AG & Co. KG, California Institute of Technology
    Inventors: Adam M. Johns, Jessica R. Herron, Richard L. Pederson, Bryan A. Fiamengo, Jennifer A. Beerman, Tzu-Pin Lin, Crystal K. Chu, Robert H. Grubbs
  • Patent number: 10781221
    Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane or hydrosiloxane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: September 22, 2020
    Assignee: California Institute of Technology
    Inventors: Anton A. Toutov, Kerry N. Betz, Andrew M. Romine, Robert H. Grubbs
  • Patent number: 10765777
    Abstract: This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: September 8, 2020
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Christopher B. Marotta
  • Patent number: 10732321
    Abstract: The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary structure. The invention also provides structures generated by self-assembly of polymer blends including at least one block copolymer component, such as a brush block polymer or wedge-type block polymer. The invention provides, for example, periodic nanostructures and microstructures generated by self-assembly of block copolymers and polymer blends comprising a mixture of at least one block copolymer component, such as a brush block copolymer, and at least a second component.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 4, 2020
    Assignee: California Institute of Technology
    Inventors: Garret M. Miyake, Raymond Weitekamp, Robert H. Grubbs, Victoria Piunova
  • Patent number: 10720666
    Abstract: Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the ?-position or does not possess a carbon in the ?-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane).
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: July 21, 2020
    Assignees: California Institute of Technology, Honda Motor Co., LTD.
    Inventors: Simon C. Jones, Victoria K. Davis, Christopher M. Bates, Nebojsa Momcilovic, Brett M. Savoie, Michael A. Webb, Thomas F. Miller, III, Robert H. Grubbs, Christopher Brooks, Kaoru Omichi
  • Publication number: 20200222311
    Abstract: The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Inventors: Vanessa M. Marx, Robert H. Grubbs
  • Publication number: 20200214890
    Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.
    Type: Application
    Filed: January 3, 2020
    Publication date: July 9, 2020
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Ying Han, Frank L. Brodie
  • Publication number: 20200185776
    Abstract: The present disclosure is directed to fluoride (F) ion batteries and F shuttle batteries comprising an anode with a solid electrolyte interphase (SEI) layer, a cathode comprising a core shell structure, and a liquid fluoride battery electrolyte. According to some aspects, the components therein enable discharge and recharge at room-temperature.
    Type: Application
    Filed: December 3, 2019
    Publication date: June 11, 2020
    Inventors: Qingmin XU, Christopher J. BROOKS, Kaoru OMICHI, Simon JONES, Victoria DAVIS, Stephen MUNOZ, Jeongmin KIM, Keith BILLINGS, Thomas MILLER, III, Robert H. GRUBBS, William WOLF
  • Patent number: 10646432
    Abstract: The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: May 12, 2020
    Assignee: California Institute of Technology
    Inventors: Vanessa M. Marx, Robert H. Grubbs