Abstract: Methods and systems represent constraint as an Ising model penalty function and a penalty gap associated therewith, the penalty gap separating a set of feasible solutions to the constraint from a set of infeasible solutions to the constraint; and determines the Ising model penalty function subject to the bounds on the programmable parameters imposed by the hardware limitations of the second processor, where the penalty gap exceeds a predetermined threshold greater than zero. Such may be employed to find quantum binary optimization problems and associated gap values employing a variety of techniques.

Abstract: Computational systems implement problem solving using heuristic solvers or optimizers. Such may iteratively evaluate a result of processing, and modify the problem or representation thereof before repeating processing on the modified problem, until a termination condition is reached. Heuristic solvers or optimizers may execute on one or more digital processors and/or one or more quantum processors. The system may autonomously select between types of hardware devices and/or types of heuristic optimization algorithms. Such may coordinate or at least partially overlap post-processing operations with processing operations, for instance performing post-processing on an ith batch of samples while generating an (i+1)th batch of samples, e.g., so post-processing operation on the ith batch of samples does not extend in time beyond the generation of the (i+1)th batch of samples. Heuristic optimizers selection is based on pre-processing assessment of the problem, e.g.

Abstract: Computational systems implement problem solving using heuristic solvers or optimizers. Such may iteratively evaluate a result of processing, and modify the problem or representation thereof before repeating processing on the modified problem, until a termination condition is reached. Heuristic solvers or optimizers may execute on one or more digital processors and/or one or more quantum processors. The system may autonomously select between types of hardware devices and/or types of heuristic optimization algorithms. Such may coordinate or at least partially overlap post-processing operations with processing operations, for instance performing post-processing on an ith batch of samples while generating an (i+1)th batch of samples, e.g., so post-processing operation on the ith batch of samples does not extend in time beyond the generation of the (i+1)th batch of samples. Heuristic optimizers selection is based on pre-processing assessment of the problem, e.g.

Abstract: Methods and systems represent constraint as an Ising model penalty function and a penalty gap associated therewith, the penalty gap separating a set of feasible solutions to the constraint from a set of infeasible solutions to the constraint; and determines the Ising model penalty function subject to the bounds on the programmable parameters imposed by the hardware limitations of the second processor, where the penalty gap exceeds a predetermined threshold greater than zero. Such may be employed to find quantum binary optimization problems and associated gap values employing a variety of techniques.

Abstract: Methods and systems to find quantum binary optimization problems and associated gap values employing a variety of techniques.

Abstract: An automatic unlatching device can be used on cages or other enclosures for pets, horses, and other animals. In the event of a fire, a portion of the device melts, permitting the latch or lock on the cage or enclosure to open. This permits the animals to escape the danger of the fire without the need for human intervention to open the lock. A hasp formed of a meltable thermoplastic material is also disclosed.

Abstract: A rotary apparatus is provided that includes a base having a top surface. The base is configured to have a mount movably connected to the top surface of the base. A drive mechanism is mounted adjacent to the top surface of the base and rotatably connected to the mount such that the mount moves along the top surface of the base. A platform is configured to receive a user of the rotary apparatus, wherein the platform is connected to the mount and rotatably connected to the drive mechanism such that the platform rotates with respect to the base at an axis point.

Abstract: A method for performing alternate and therefore least cost routing in distributed H.323 Voice over IP (VoIP) networks is provided. With this method, the VoIP network consists of a hierarchy of gatekeeper (GK) functions to provide alternate routing, network element redundancy, and scalability. The alternate routing function is performed by a directory gatekeeper with route selection advancing from a first route to a second route by either of two conditions: (1) there are no resources available to terminate the call in the first zone; and (2) a lack of response to the directory GK request for such resources.

Abstract: Methods are described which enable the operator of a network such as an Internet protocol (IP) network to allocate ingress and egress channel capacity for the use by different services or for use by different service providers. The methods can prevent a service provider or a service from overusing network capacity. The methods also enable the network operator to temporarily allocate unused capacity if demand for a service exceeds previously allocated capacity. Further a method is described whereby capacity on a Voice over Internet protocol (VoIP) network is sold to service providers with guarantees for the number of available channels, where the channel capacity guarantees could be global, or by any type of subdivision. In addition to having a committed channel capacity, the service provider could be allowed to exceed the committed capacity whenever excess capacity is available on the network.

Abstract: Methods and systems are described for performing alternate routing of communications in a network. The system initiates a communication from an origination endpoint in a packet-switched network, such as a VOIP network, to a destination endpoint, and determining, according to selection criteria, whether to route the communication to the destination endpoint using at least a second circuit-switched network, such as the PSTN.

Abstract: A multiservice network for delivering enhanced communication services to customer devices attached to either the PSTN, such as telephones and fax machines, or devices attached to the Internet or private data networks, such as PCs or other IP devices, is presented. Enhanced services include IP-based faxing, IP-based telephony, IP-based conferencing, Internet call waiting, messaging services, such as unified messaging, and other advanced services such as find-me-follow-me, and desktop telephony. The multiservice network may be managed by a configuration manager for Internet telephony (COMIT).

Abstract: This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral load-reducing doses of (a) a humanized antibody designated PRO 140, or of (b) an anti-CCR5 receptor monoclonal antibody. This invention also provides a method for inhibiting in a human subject the onset or progression of an HIV-1-associated disorder, the inhibition of which is effected by inhibiting fusion of HIV-1 to CCR5+CD4+ target cells in the subject. This invention also provides a method for treating a subject infected with HIV-1 comprising administering to the subject (a) a monoclonal antibody which (i) binds to a CCR5 receptor on the surface of the subject's CD4+ cells and (ii) inhibits fusion of HIV-1 to the subject's CCR5+CD4+ cells, and (b) a non-antibody CCR5 receptor antagonist, in amounts effective to treat the subject.

Abstract: Methods and compositions for treating post-surgical gastrointestinal dysfunction are provided. Methods include administering a quaternary derivative of noroxymorphone (e.g., methylnaltrexone) to a patient after a segmental colectomy is performed on the patient.

Abstract: A consumer inserts a consumable product into a main storage area of the present device. A lid is secured to the top of the container. By tipping the container to the proper angle, product from main storage area is forced into holding barrier volume at the top of the container resulting in a specific amount of product to be held by the barrier. The container is then tipped upright and the measured product amount drops into the bottom of a measure compartment. The container is then inverted once more with the top of measure compartment now open, thereby allowing the measured product to be dispensed from the container, whereby the product from the main storage area is again forced into the holding barrier and process may be repeated.

Abstract: The present invention provides a system and method for establishing the availability of a node to received a voice over internet protocol (VoIP) call. The present invention comprises attempting to establish a VoIP call to a given node that is the target of the VoIP call, determining whether the attempt to establish the VoIP call is successful; and generating an alarm in response to a call failure. According to embodiments of the invention, the method may comprise extracting call metrics from a VoIP call that provide information regarding the quality of a VoIP connection and generating an alarm in response to the call metrics falling below a threshold.

Abstract: Methods and systems are described for performing alternate routing of communications in a network. The system initiates a communication from an origination endpoint in a packet-switched network, such as a VoIP network, to a destination endpoint, and determining, according to selection criteria, whether to route the communication to the destination endpoint using at least a second circuit-switched network, such as the PSTN.

Abstract: Methods of treating irritable bowel syndrome with peripheral opioid antagonists, such as methylnaltrexone, are provided. Formulations comprising peripheral opioid antagonists, such as methylnaltrexone, and irritable bowel syndrome therapeutic agents are also provided.

Abstract: The present invention provides a system and method for establishing the availability of a node to received a voice over internet protocol (VoIP) call. The present invention comprises attempting to establish a VoIP call to a given node that is the target of the VoIP call, determining whether the attempt to establish the VoIP call is successful; and generating an alarm in response to a call failure. According to embodiments of the invention, the method may comprise extracting call metrics from a VoIP call that provide information regarding the quality of a VoIP connection and generating an alarm in response to the call metrics falling below a threshold.