Patents by Inventor Robert J. Brosnan
Robert J. Brosnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11696898Abstract: A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of methyl-ethyl ethers, methyl-isopropyl ethers, and methyl-propyl ethers.Type: GrantFiled: September 25, 2020Date of Patent: July 11, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Robert J. Brosnan
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Publication number: 20220288011Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: ApplicationFiled: November 2, 2020Publication date: September 15, 2022Applicant: The Regents of the University of CaliforniaInventor: Robert J. Brosnan
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Publication number: 20210330604Abstract: A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of methyl-ethyl ethers, methyl-isopropyl ethers, and methyl-propyl ethers.Type: ApplicationFiled: September 25, 2020Publication date: October 28, 2021Applicant: The Regents of the University of CaliforniaInventor: Robert J. Brosnan
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Publication number: 20210322363Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: ApplicationFiled: November 2, 2020Publication date: October 21, 2021Applicant: The Regents of the University of CaliforniaInventor: Robert J. Brosnan
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Publication number: 20190000793Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: ApplicationFiled: May 22, 2018Publication date: January 3, 2019Applicant: The Regents of the University of CaliforniaInventor: Robert J. Brosnan
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Publication number: 20180296499Abstract: A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of methyl-ethyl ethers, methyl-isopropyl ethers, and methyl-propyl ethers.Type: ApplicationFiled: January 17, 2018Publication date: October 18, 2018Applicant: The Regents of the University of CaliforniaInventor: Robert J. Brosnan
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Patent number: 10010525Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: GrantFiled: October 19, 2017Date of Patent: July 3, 2018Assignee: The Regents of the University of CaliforniaInventor: Robert J. Brosnan
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Publication number: 20180116997Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: ApplicationFiled: October 19, 2017Publication date: May 3, 2018Applicant: The Regents of the University of CaliforniaInventor: Robert J. Brosnan
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Patent number: 9757353Abstract: Methods of inducing anesthesia in a subject by administering an effective amount of a compound or a mixture of compounds according to Formula I are provided. Compounds of Formula I are a class of halogenated alcohol derivatives with a vapor pressure of at least 0.1 atmospheres (76 mmHg) at 25° C. Compounds of Formula I can be administered by any route sufficient to achieve a desired anesthetic endpoint.Type: GrantFiled: June 17, 2016Date of Patent: September 12, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Robert J. Brosnan
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Publication number: 20160296496Abstract: The present invention provides methods for determining the selectivity of a sedative for an anesthetic-sensitive receptor by determining the molar water solubility of the sedative. The invention further provides methods for modulating the selectivity of a sedative for an anesthetic-sensitive receptor by altering or modifying the sedative to have higher or lower water solubility. The invention further provides methods of inducing sedation in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods and at a vapor pressure less than 0.1 atm (76 mm Hg).Type: ApplicationFiled: June 17, 2016Publication date: October 13, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: ROBERT J. BROSNAN
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Patent number: 9381185Abstract: The present invention provides methods of inducing sedation in a subject by administering an effective amount of a compound or a mixture of compounds according to Formula I. Compounds of Formula I are a class of halogenated alcohol derivatives with a vapor pressure of less than 0.1 atmospheres (76 mmHg) at 25° C. The compounds of the present invention can be administered by any route sufficient to achieve a desired anesthetic, amnestic, analgesic, or sedative effect.Type: GrantFiled: July 10, 2013Date of Patent: July 5, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Robert J. Brosnan
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Publication number: 20160113887Abstract: A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of methyl-ethyl ethers, methyl-isopropyl ethers, and methyl-propyl ethers.Type: ApplicationFiled: June 4, 2015Publication date: April 28, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Robert J. Brosnan
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Publication number: 20150157596Abstract: The present invention provides methods for determining the selectivity of a sedative for an anesthetic-sensitive receptor by determining the molar water solubility of the sedative. The invention further provides methods for modulating the selectivity of a sedative for an anesthetic-sensitive receptor by altering or modifying the sedative to have higher or lower water solubility. The invention further provides methods of inducing sedation in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods and at a vapor pressure less than 0.1 atm (76 mm Hg).Type: ApplicationFiled: July 10, 2013Publication date: June 11, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Robert J. Brosnan
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Publication number: 20140018414Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: ApplicationFiled: March 14, 2013Publication date: January 16, 2014Inventor: Robert J. Brosnan