Patents by Inventor Robert J. Devita

Robert J. Devita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYDROXYMETHYL ETHER HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS
    Publication number: 20100105747
    Abstract: The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
    Type: Application
    Filed: April 7, 2008
    Publication date: April 29, 2010
    Inventors: Robert J. DeVita, Sander G. Mills, Jinlong Jiang, Andrew J. Kassick, Jianming Bao
  • Anti-hypercholesterolemic compounds
    Patent number: 7704988
    Abstract: This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: April 27, 2010
    Assignee: Merck & Co., Inc.
    Inventors: Robert J. DeVita, Gregori J. Morriello, Peter Lin
  • Anti-hypercholesterolemic compounds
    Patent number: 7696177
    Abstract: This invention provides cholesterol absorption inhibitors of Formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: April 13, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Robert J. DeVita, Greg J. Morriello, Anthony K. Ogawa, Feroze Ujjainwalla
  • Hydroisoindoline tachykinin receptor antagonists
    Patent number: 7683068
    Abstract: The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: March 23, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jinlong Jiang, Robert J. DeVita, Sanjeev Kumar, Sander G. Mills, Richard A. Tschirret-Guth
  • HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS
    Publication number: 20100069347
    Abstract: This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.
    Type: Application
    Filed: October 30, 2007
    Publication date: March 18, 2010
    Inventors: Gregori J. Morriello, Robert J. DeVita, Christopher R. Moyes
  • ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS
    Publication number: 20100035857
    Abstract: This invention provides cholesterol absorption inhibitors of Formula I:I and the pharmaceutically acceptable salts thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
    Type: Application
    Filed: December 14, 2007
    Publication date: February 11, 2010
    Inventors: Robert J. DeVita, Gregori J. Morriello, Peter Lin
  • Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists
    Patent number: 7652058
    Abstract: The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: January 26, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Robert J. DeVita, Jinlong Jiang, Sander G. Mills, Jonathan R. Young
  • Hydroisoindoline tachykinin receptor antagonists
    Patent number: 7645790
    Abstract: The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: January 12, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jaime Lynn Bunda, Robert J. DeVita, Jinlong Jiang, Sander G. Mills
  • 5,6,Fused Pyrrolidine Compounds Useful as Tachykinin Receptor Antagonists
    Publication number: 20090286777
    Abstract: The present invention is directed to certain 5,6-fused pyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: May 11, 2007
    Publication date: November 19, 2009
    Inventors: Jianming Bao, Robert J. DeVita, Sander G. Mills, Gregori J. Morriello
  • Fused Triazole Tachykinin Receptor Antagonists
    Publication number: 20090221611
    Abstract: The present invention is directed to certain fused triazole compounds which are useful as neurokinin-1 (NK-I) receptor antagonists, and inhibitors of tachykinin and in particular substance P- The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: January 5, 2007
    Publication date: September 3, 2009
    Inventors: Robert J. DeVita, Jonathan R. Young
  • Anti-Hypercholesterolemic Compounds
    Publication number: 20090137546
    Abstract: This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
    Type: Application
    Filed: September 29, 2006
    Publication date: May 28, 2009
    Inventors: Robert J. DeVita, Gregori J. Morriello, Peter Lin
  • Hydroisoindoline tachykinin receptor antagonists
    Publication number: 20090054462
    Abstract: The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: June 23, 2006
    Publication date: February 26, 2009
    Inventors: Jinlong Jiang, Robert J. DeVita, Sanjeev Kumar, Sander G. Mills, Richard A. Tschirret-Guth
  • Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists
    Publication number: 20090048248
    Abstract: The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: December 18, 2006
    Publication date: February 19, 2009
    Inventors: Robert J. DeVita, Jianming Bao, Sander G. Mills
  • Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists
    Publication number: 20090042854
    Abstract: The present invention is directed to certain hexahydrpyrrolidinone compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: January 19, 2007
    Publication date: February 12, 2009
    Inventors: Jianming Bao, Robert J. DeVita, Huagang Lu, Sander G. Mills, Gregori J. Morriello
  • Phenyl pyrrolidine ether tachykinin receptor antagonists
    Patent number: 7468437
    Abstract: The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, depression, and anxiety.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: December 23, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Robert J. DeVita, Peter Lin, Sander G. Mills, Jonathan R. Young
  • Anti-hypercholesterolemic biaryl azetidinone compounds
    Publication number: 20080280836
    Abstract: This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is an alkyl, alkeny or alkynyl group mono- or poly-substituted with —OH, —COOH or a combination of —OH and —COOH, and R9 contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 13, 2008
    Inventors: Gregori J. Morriello, Robert J. DeVita
  • Hydroisoindoline Tachykinin Receptor Antagonists
    Publication number: 20080280966
    Abstract: The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: January 26, 2005
    Publication date: November 13, 2008
    Inventors: Jaime Lynn Bunda, Robert J. DeVita, Jinlong Jiang, Sander G. Mills
  • Cycloalkyl Piperidine Tachykinin Receptor Antagonists
    Publication number: 20080153851
    Abstract: The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: November 18, 2005
    Publication date: June 26, 2008
    Inventors: Robert J. DeVita, Sander G. Mills, Ronsar Eid, Jonathan R. Young
  • Piperidinyl Piperidine Tachykinin Receptor Antagonists
    Publication number: 20080146588
    Abstract: The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: November 18, 2005
    Publication date: June 19, 2008
    Inventors: Robert J. Devita, Sander G. Mills, Ronsar Eid, Jonathan R. Young
  • Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists
    Publication number: 20080108689
    Abstract: The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
    Type: Application
    Filed: December 12, 2005
    Publication date: May 8, 2008
    Inventors: Robert J. Devita, Jinlong Jiang, Sander G. Mills, Jonathan R. Young