Patents by Inventor Robert Jeffrey Copeland

Robert Jeffrey Copeland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5912355
    Abstract: Method of preparing an optically active compound of formula, wherein R and R.sup.1 are independently alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, cycloalkyl, aryl, aralkyl, a heterocyclic group or a C.sub.1 -C.sub.4 alkyl-heterocycle, each being optionally substituted, procided that R and R.sup.1 are not identical and * is an optically active chiral center, from the corresponding racemic ester or diol by treating with a hydrolase enzyme.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: June 15, 1999
    Assignees: Zeneca Limited, Mochida Pharmaceutical Co., Ltd.
    Inventors: Andrew John Blacker, Andrew George Brewster, Robert Jeffrey Copeland, Robert Antony Holt
  • Patent number: 5854062
    Abstract: Method of preparing an optically active compound of formula, wherein R and R.sup.1 are independently alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, cycloalkyl, aryl, aralkyl, a heterocyclic group or a C.sub.1 -C.sub.4 alkyl-heterocycle, each being optionally substituted, procided that R and R.sup.1 are not identical and * is an optically active chiral center, from the corresponding racemic ester or diol by treating with a hydrolase enzyme. In particular, racemic 2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2 diol, an intermediate in fluconazole synthesis, is resolved using porcine pancreatic lipase or lipase from Chromobacterium viscosum.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: December 29, 1998
    Assignees: Zeneca Limited, Mochida Pharmaceuticals Co., Ltd.
    Inventors: Andrew John Blacker, Andrew George Brewster, Robert Jeffrey Copeland, Robert Antony Holt