Patents by Inventor Robert K. O'Leary
Robert K. O'Leary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9585986Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: GrantFiled: February 28, 2014Date of Patent: March 7, 2017Assignee: Lifenet HealthInventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Billy G. Anderson
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Patent number: 9579420Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: GrantFiled: February 8, 2010Date of Patent: February 28, 2017Assignee: Lifenet HealthInventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Billy G. Anderson
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Patent number: 9339589Abstract: The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media.Type: GrantFiled: December 6, 2012Date of Patent: May 17, 2016Assignee: LifeNet HealthInventors: Debra Moore-Smith, Robert K. O'Leary, Anne Wilson
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Patent number: 9125971Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: GrantFiled: March 15, 2013Date of Patent: September 8, 2015Assignee: LifeNet HealthInventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Billy G. Anderson
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Publication number: 20140180437Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: ApplicationFiled: February 28, 2014Publication date: June 26, 2014Applicant: LifeNet HealthInventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Billy G. Anderson (deceased)
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Patent number: 8337780Abstract: The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media.Type: GrantFiled: January 6, 2010Date of Patent: December 25, 2012Assignee: LifeNet HealthInventors: Barton D. Gaskins, Louis Ford, Debra Moore-Smith, Robert K. O'Leary, Anne Wilson, Lloyd Wolfinbarger, Jr.
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Publication number: 20110027871Abstract: The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media.Type: ApplicationFiled: January 6, 2010Publication date: February 3, 2011Applicant: LifeNet HealthInventors: Barton D. Gaskins, Louis Ford, Debra Moore-Smith, Robert K. O'Leary, Anne Wilson, Lloyd Wolfinbarger, JR.
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Publication number: 20110015757Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: ApplicationFiled: February 8, 2010Publication date: January 20, 2011Applicant: LifeNet HealthInventors: Lloyd Wolfinbarger, JR., Robert K. O'Leary, Billy G. Anderson
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Patent number: 6926901Abstract: The invention is an animal repellant composition containing one or more plant derived toxins, including for example one or more alkaloids isolated from for example, one or more members of the family Narcissus, and optionally containing one or more polymers, including for example one or more bioerodible polymers and/or more non-absorbable polymers. The animal repellant composition is useful for repelling animals from vegetation and for rendering vegetation unpalatable to animals. The invention also includes methods for repelling animals, as well as methods for treating vegetation to render the vegetation unpalatable to animals, such animals including for example, deer, voles, moles, ground hogs, mice, rats, rodents, raccoons, nematodes, larvae, worms, fungi, molds, bacteria, vegetative organisms, and insects. A suberin-polymer-repellant chemical complex and a method for treating damaged vegetation are also disclosed.Type: GrantFiled: April 22, 2003Date of Patent: August 9, 2005Assignee: The Corato FoundationInventor: Robert K. O'Leary
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Patent number: 6878938Abstract: A high frequency infrared radiation source including a hermetically sealed chamber with a plasma generating gas therein, a pair of spaced electrodes in the chamber for creating a plasma therebetween, a window in the chamber, and a collimating lens made of infrared radiation transmissive material disposed between the pair of electrodes and the window.Type: GrantFiled: July 16, 2003Date of Patent: April 12, 2005Assignee: PerkinElmer, Inc.Inventors: Robert K. O'Leary, William Manning, Christopher G. Poirier, David Jacobsen, David Vidal
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Patent number: 6837907Abstract: The invention is directed to a method of debriding bone including incubating the bone and associated soft tissue, with one or more debriding solutions where the debriding solution may include one or more alkaline solutions. Incubation is optionally carried out with one or more debriding agents including inert dry granular or particulate material including for example beads, and the granular phase of an alkaline agent, including for example granular sodium hydroxide. The incubating may be carried out with agitation. In another embodiment, the medullary canal of the bone is subjected to a positive pressure stream of debriding solution under conditions sufficient to loosen the associated soft tissue from the bone at the interface of the soft tissue and bone. In a further embodiment, the debriding solution is provided as a gel.Type: GrantFiled: March 27, 2002Date of Patent: January 4, 2005Assignee: LifeNetInventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Louis Ford, Alyce Linhurst Jones
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Patent number: 6830763Abstract: The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid continuous acid demineralization process. The process includes subjecting bone to a continuous exchange of demineralizing acid solution where the demineralizing acid solution is recirculated from the substantially closed container through an ion exchange media to remove calcium and phosphate thereby producing a regenerated acid, and returning the regenerated acid to the substantially closed container to produce osteoinductive demineralized bone. The process allows bone to be rapidly demineralized to a precise and specific desired residual calcium level, without sacrificing osteoinductivity.Type: GrantFiled: June 26, 2002Date of Patent: December 14, 2004Assignee: LifeNetInventors: Robert K. O'Leary, Jan Zajdowicz, Lloyd Wolfinbarger, Jr.
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Publication number: 20040236242Abstract: A capnograph system sensor head includes an airway adapter, a housing for receiving the airway adapter, a source of infrared radiation coupled to the housing for directing infrared radiation through the airway adapter, and a detector subsystem coupled to the housing and responsive to the infrared radiation after it passes through the airway adapter for providing an analog output. A circuit sub-assembly is integrated with the sensor head and includes a controller responsive to the analog output of the detector subsystem. The controller is configured to adjust the gain of the detector subsystem to output a digital signal representative of the amount of a particular gas flowing through the airway adapter.Type: ApplicationFiled: May 22, 2003Publication date: November 25, 2004Inventors: James E. Graham, Robert K. O'Leary, Dennis Witz, David Vidal
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Publication number: 20030202998Abstract: The invention is an animal repellant composition containing one or more plant derived toxins, including for example one or more alkaloids isolated from for example, one or more members of the family Narcissus, and optionally containing one or more polymers, including for example one or more bioerodible polymers and/or more non-absorbable polymers. The animal repellant composition is useful for repelling animals from vegetation and for rendering vegetation unpalatable to animals. The invention also includes methods for repelling animals, as well as methods for treating vegetation to render the vegetation unpalatable to animals, such animals including for example, deer, voles, moles, ground hogs, mice, rats, rodents, raccoons, nematodes, larvae, worms, fungi, molds, bacteria, vegetative organisms, and insects. A suberin-polymer-repellant chemical complex and a method for treating damaged vegetation are also disclosed.Type: ApplicationFiled: April 22, 2003Publication date: October 30, 2003Inventor: Robert K. O'Leary
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Publication number: 20030135284Abstract: The invention provides a plasticized bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in natural tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the plasticized bone or soft tissue product can be placed directly into an implant site without significant preparation in the operating room.Type: ApplicationFiled: November 7, 2002Publication date: July 17, 2003Inventors: Katrina Crouch, Lloyd Wolfinbarger, Robert K. O'Leary, Louis Ford
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Patent number: 6569200Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: GrantFiled: June 5, 2001Date of Patent: May 27, 2003Assignee: LifeNetInventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Billy G. Anderson
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Patent number: 6565867Abstract: The invention is an animal repellant composition containing one or more plant derived toxins, including for example one or more alkaloids isolated from for example, one or more members of the family Narcissus, and optionally containing one or more polymers, including for example one or more bioerodible polymers and/or one or more non-absorbable polymers. The animal repellant composition is useful for repelling animals from vegetation and for rendering vegetation unpalatable to animals. The invention also includes methods for repelling animals, as well as methods for treating vegetation to render the vegetation unpalatable to animals, such animals including for example, deer, voles, moles, ground hogs, mice, rats, rodents, racoons, nematodes, larvae, worms, fungi, molds, bacteria, vegetative organisms, and insects.Type: GrantFiled: December 12, 2000Date of Patent: May 20, 2003Assignee: The Corato FoundationInventor: Robert K. O'Leary
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Publication number: 20030083752Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: ApplicationFiled: August 29, 2001Publication date: May 1, 2003Inventors: Lloyd Wolfinbarger, Robert K. O'Leary, Billy G. Anderson
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Patent number: 6544289Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.Type: GrantFiled: June 22, 2001Date of Patent: April 8, 2003Assignee: LifeNetInventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Billy G. Anderson
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Patent number: 6534095Abstract: The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid high volume, pulsatile acidification wave process. The process includes subjecting bone to two or more rapid pulse/drain cycles where one or more demineralizing acids are rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel, the vessel containing the bone is then rapidly refilled with the one or more demineralizing acids (pulsed). The process allows bone to be rapidly demineralized to a precise ans specific desired residual calcium level, without sacrificing osteoinductivity.Type: GrantFiled: September 5, 2000Date of Patent: March 18, 2003Assignee: LifeNetInventors: Debra Moore-Smith, Robert K. O'Leary, Anne Wilson