Patents by Inventor Robert Narquizian

Robert Narquizian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monocyclic substituted phenyl methanones
    Publication number: 20060167009
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, X1, and X2 are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Such compounds are inhibitors of the glycine transporter 1 (GlyT-1) and can be used in the treatment of schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: January 3, 2006
    Publication date: July 27, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Substituted phenyl methanone derivatives
    Publication number: 20060160788
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, n, and m, are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) and are useful for the treatment of CNS disorders such as schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: January 17, 2006
    Publication date: July 20, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Benzoyl-tetrahydropiperidine derivatives
    Publication number: 20060148797
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, and Ar; are as defined in the specification. The invention also provides pharmaceutically acceptable acid addition salts thereof and methods for the treatment of neurological and neuropsychiatric disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: December 13, 2005
    Publication date: July 6, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Sulfanyl substituted phenyl methanones
    Publication number: 20060149062
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: January 3, 2006
    Publication date: July 6, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Aminocycloalkanes as DPP-IV inhibitors
    Publication number: 20060135512
    Abstract: The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 22, 2006
    Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Loeffler, Hans Marty, Patrizio Mattei, Robert Narquizian
  • Bi- and tricyclic substituted phenyl methanones
    Publication number: 20060128713
    Abstract: The present invention relates to compounds of the general formula I and R1, R?,; R?, R2, R3, R4, R5, R6, R7, m and n are as defined in the specification, and to pharmaceutically active acid addition salts thereof. The compounds of the invention are useful in the treatment of neurological and neuropsychiatric disorders.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 15, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups
    Publication number: 20060128712
    Abstract: The present invention relates to compounds of the general formula I wherein R1 is the group and R2, R?, R?, R3, R4, R5, R6, R7, X1, X1?, X2, and N are as defined in the specification. Compounds of the invention are useful for the treatment of neurological and neuropsychiatric disorders.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 15, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Heterocyclic cannabinoid receptor antagonists
    Publication number: 20050250769
    Abstract: The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
    Type: Application
    Filed: May 9, 2005
    Publication date: November 10, 2005
    Inventors: Alexander Mayweg, Robert Narquizian, Philippe Pflieger, Stephan Roever
  • Benzoyl-piperazine derivatives
    Publication number: 20050209241
    Abstract: The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
    Type: Application
    Filed: August 4, 2004
    Publication date: September 22, 2005
    Inventors: Synese Jolidon, Robert Narquizian, Matthias Nettekoven, Roger Norcross, Emmanuel Pinard, Henri Stalder
  • Pyrido[2,1-a]isoquinoline derivatives
    Patent number: 6897222
    Abstract: The present invention provides compounds of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: May 24, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Claudio Gobbi, Thomas Luebbers, Patrizio Mattei, Robert Narquizian, Pierre Charles Wyss
  • Benzoyl-piperazine derivatives
    Publication number: 20050070539
    Abstract: A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
    Type: Application
    Filed: September 2, 2004
    Publication date: March 31, 2005
    Inventors: Daniela Alberati-Giani, Synese Jolidon, Robert Narquizian, Matthias Nettekoven, Roger Norcross, Emmanuel Pinard, Henri Stadler
  • Substituted acylpiperazine derivatives
    Publication number: 20050059668
    Abstract: The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
    Type: Application
    Filed: September 1, 2004
    Publication date: March 17, 2005
    Inventors: Daniela Alberati-Giani, Synese Jolidon, Robert Narquizian, Matthias Nettekoven, Roger Norcross, Emmanuel Pinard, Henri Stalder
  • Pyrido [2,1-a] isoquinoline derivatives
    Publication number: 20040259902
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: June 17, 2004
    Publication date: December 23, 2004
    Inventors: Markus Boehringer, Bernd Kuhn, Thomas Luebbers, Patrizio Mattei, Robert Narquizian, Hans Peter Wessel
  • Pyrido [2,1-a] isoquinoline derivatives
    Publication number: 20040259903
    Abstract: The present invention provides compounds of formula (I) 1
    Type: Application
    Filed: June 17, 2004
    Publication date: December 23, 2004
    Inventors: Markus Boehringer, Bernd Kuhn, Patrizio Mattei, Robert Narquizian
  • Pyrido [2,1-a] isoquinoline derivatives
    Publication number: 20040176406
    Abstract: The present invention provides compounds of formula (I) 1
    Type: Application
    Filed: March 15, 2004
    Publication date: September 9, 2004
    Inventors: Luca Claudio Gobbi, Thomas Luebbers, Patrizio Mattei, Robert Narquizian, Pierre Charles Wyss
  • Novel CB 1 receptor inverse agonists
    Publication number: 20040167129
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: December 22, 2003
    Publication date: August 26, 2004
    Inventors: Alexander Mayweg, Hans Peter Marty, Werner Mueller, Robert Narquizian, Werner Neidhart, Philippe Pflieger, Stephan Roever
  • Novel pyrrolyl-thiazole derivatives
    Publication number: 20040147572
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: December 22, 2003
    Publication date: July 29, 2004
    Inventors: Wolfgang Guba, Wolfgang Haap, Hans Peter Marty, Robert Narquizian
  • Pyrido[2,1-A]Isoquinoline derivatives
    Patent number: 6727261
    Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: April 27, 2004
    Assignee: Hoffman-La Roche Inc.
    Inventors: Luca Claudio Gobbi, Thomas Luebbers, Patrizio Mattei, Robert Narquizian, Pierre Charles Wyss
  • Pyrido [2,1-a] isoquinoline derivatives
    Publication number: 20030149071
    Abstract: The present invention provides compounds of formula (I) 1
    Type: Application
    Filed: December 17, 2002
    Publication date: August 7, 2003
    Inventors: Luca Claudio Gobbi, Thomas Luebbers, Patrizio Mattei, Robert Narquizian, Pierre Charles Wyss