Patents by Inventor Robert Terbrueggen
Robert Terbrueggen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10829803Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more oligonucleotide probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligated oligonucleotide product. In accordance with the invention, the presence of the target(s) of interest can be determined by measuring the presence or amount of ligated oligonucleotide product.Type: GrantFiled: May 10, 2007Date of Patent: November 10, 2020Assignee: DXTERITY DIAGNOSTICS INCORPORATEDInventor: Robert Terbrueggen
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Patent number: 10463347Abstract: The present invention generally relates to devices and methods for collecting and stabilizing biological samples, and more particularly, for collecting and stabilizing blood or other bodily fluids from a user's fingertip, earlobe, heel or other locations. The present invention also relates to sample collection devices that simplify the process for mixing the biological samples with an additive or additives, provide for efficient storage and safe transport of the samples, and provide for easy access to the samples for subsequent processing.Type: GrantFiled: September 8, 2017Date of Patent: November 5, 2019Assignee: DXTERITY DIAGNOSTICS INCORPORATEDInventors: Robert Terbrueggen, Scott Gordon Beach
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Publication number: 20190106739Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more oligonucleotide probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligated oligonucleotide product. In one aspect, the ligation product is of variable length that correlates with a particular target. Following chemical ligation, the probes may be amplified and detected by capillary electrophoresis or microarray analysis.Type: ApplicationFiled: May 21, 2018Publication date: April 11, 2019Inventor: Robert Terbrueggen
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Patent number: 10066257Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more ligation probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligation product that is directly detected or that is amplified to produce amplicons that are then detected. The present invention also provides methods to stabilize sample RNA so that degradation does not significantly affect the results of the analysis.Type: GrantFiled: May 17, 2012Date of Patent: September 4, 2018Assignee: DXTERITY DIAGNOSTICS INCORPORATEDInventors: Robert Terbrueggen, Yenbou Liu, John Ray Childers, Jr., Chang Hee Kim, Majid R. Abedi
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Publication number: 20180153522Abstract: The present invention generally relates to devices and methods for collecting and stabilizing biological samples, and more particularly, for collecting and stabilizing blood or other bodily fluids from a user's fingertip, earlobe, heel or other locations. The present invention also relates to sample collection devices that simplify the process for mixing the biological samples with an additive or additives, provide for efficient storage and safe transport of the samples, and provide for easy access to the samples for subsequent processing.Type: ApplicationFiled: September 8, 2017Publication date: June 7, 2018Inventors: ROBERT TERBRUEGGEN, SCOTT GORDON BEACH
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Patent number: 9976177Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more oligonucleotide probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligated oligonucleotide product. In one aspect, the ligation product is of variable length that correlates with a particular target. Following chemical ligation, the probes may be amplified and detected by capillary electrophoresis or microarray analysis.Type: GrantFiled: March 29, 2010Date of Patent: May 22, 2018Assignee: DXTERITY DIAGNOSTICS INCORPORATEDInventor: Robert Terbrueggen
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Publication number: 20180030520Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more ligation probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligation product that is directly detected or that is amplified to produce amplicons that are then detected. The present invention also provides methods to stabilize sample RNA so that degradation does not significantly affect the results of the analysis.Type: ApplicationFiled: August 7, 2017Publication date: February 1, 2018Inventors: Robert TERBRUEGGEN, Yenbou LIU, John Ray CHILDERS, Chang Hee KIM, Majid R. ABEDI
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Patent number: 9874542Abstract: The invention relates to the use of signal processing methods in order to achieve higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.Type: GrantFiled: October 14, 2014Date of Patent: January 23, 2018Assignee: CLINICAL MICRO SENSORS, INC.Inventors: Robert M. Umek, Gary Blackburn, Bruce D. Irvine, Robert Terbrueggen, Changjun Yu, Jost G. Vielmetter
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Patent number: 9757095Abstract: The present invention generally relates to devices and methods for collecting and stabilizing biological samples, and more particularly, for collecting and stabilizing blood or other bodily fluids from a user's fingertip, earlobe, heel or other locations. The present invention also relates to sample collection devices that simplify the process for mixing the biological samples with an additive or additives, provide for efficient storage and safe transport of the samples, and provide for easy access to the samples for subsequent processing.Type: GrantFiled: June 10, 2015Date of Patent: September 12, 2017Assignee: DXTERITY DIAGNOSTICS INCORPORATEDInventors: Robert Terbrueggen, Scott Gordon Beach
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Patent number: 9745616Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more ligation probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligation product that is directly detected or that is amplified to produce amplicons that are then detected. The present invention also provides methods to stabilize sample RNA so that degradation does not significantly affect the results of the analysis.Type: GrantFiled: May 17, 2012Date of Patent: August 29, 2017Assignee: DXTERITY DIAGNOSTICS INCORPORATEDInventors: Robert Terbrueggen, Yenbou Liu, John Ray Childers, Jr., Chang Hee Kim, Majid R. Abedi
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Publication number: 20160045187Abstract: The present invention generally relates to devices and methods for collecting and stabilizing biological samples, and more particularly, for collecting and stabilizing blood or other bodily fluids from a user's fingertip, earlobe, heel or other locations. The present invention also relates to sample collection devices that simplify the process for mixing the biological samples with an additive or additives, provide for efficient storage and safe transport of the samples, and provide for easy access to the samples for subsequent processing.Type: ApplicationFiled: June 10, 2015Publication date: February 18, 2016Inventors: Robert TERBRUEGGEN, Scott Gordon Beach
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Publication number: 20150126391Abstract: The invention relates to the use of signal processing methods in order to achieve higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.Type: ApplicationFiled: October 14, 2014Publication date: May 7, 2015Applicant: GenMark Diagnostics Inc.Inventors: Robert M. UMEK, Gary Blackburn, Bruce D. Irvine, Robert Terbrueggen, Changjun Yu, Jost G. Vielmetter
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Publication number: 20140171338Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more ligation probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligation product that is directly detected or that is amplified to produce amplicons that are then detected. The present invention also provides methods to stabilize sample RNA so that degradation does not significantly affect the results of the analysis.Type: ApplicationFiled: May 17, 2012Publication date: June 19, 2014Applicant: DXTERITY DIAGNOSTICS INCORPORATEDInventors: Robert Terbrueggen, Yenbou Liu, John Ray Childers, Chang Hee Kim, Majid R. Abedi
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Publication number: 20130005594Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more ligation probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligation product that is directly detected or that is amplified to produce amplicons that are then detected. The present invention also provides methods to stabilize sample RNA so that degradation does not significantly affect the results of the analysis.Type: ApplicationFiled: May 17, 2012Publication date: January 3, 2013Applicant: DxTerity Diagnostics IncorporatedInventors: Robert Terbrueggen, Yenbou Liu, John Ray Childers, JR., Chang Hee Kim, Majid R. Abedi
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Publication number: 20100267585Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more oligonucleotide probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligated oligonucleotide product. In one aspect, the ligation product is of variable length that correlates with a particular target. Following chemical ligation, the probes may be amplified and detected by capillary electrophoresis or microarray analysis.Type: ApplicationFiled: March 29, 2010Publication date: October 21, 2010Inventor: Robert Terbrueggen
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Publication number: 20080124810Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more oligonucleotide probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligated oligonucleotide product. In accordance with the invention, the presence of the target(s) of interest can be determined by measuring the presence or amount of ligated oligonucleotide product.Type: ApplicationFiled: May 10, 2007Publication date: May 29, 2008Applicant: DXTERITY DIAGNOSTICSInventor: Robert Terbrueggen
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Publication number: 20070189921Abstract: The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.Type: ApplicationFiled: January 11, 2001Publication date: August 16, 2007Inventors: Hau Duong, Gary Blackburn, Jon Kayyem, Stephen O'Connor, Gary Olsen, Robert Pietri, Robert Terbrueggen
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Publication number: 20060160205Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: ApplicationFiled: November 5, 2001Publication date: July 20, 2006Inventors: Gary Blackburn, Hau Duong, Piotr Grodzinski, Jon Kayyem, Stephen O'Connor, Robert Pietri, Robert Terbrueggen, Frederic Zenhausern, Gary Olsen
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Publication number: 20050244954Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.Type: ApplicationFiled: March 16, 2005Publication date: November 3, 2005Inventors: Gary Blackburn, Stephen Creager, Scott Fraser, Bruce Irvine, Thomas Meade, Stephen O'Connor, Robert Terbrueggen, Jost Vielmetter, Thomas Welch
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Publication number: 20050053962Abstract: The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.Type: ApplicationFiled: November 15, 2004Publication date: March 10, 2005Inventors: Gary Blackburn, Bruce Irvine, Jon Kayyem, Edward Sheldon, Robert Terbrueggen