Patents by Inventor Robert W. Langley
Robert W. Langley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110224064Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber a baffle within a separation area. The baffle may have a plurality of vanes with openings therein. A protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet.Type: ApplicationFiled: May 19, 2011Publication date: September 15, 2011Applicant: CaridianBCT, Inc.Inventors: John PITTINGER, Logan FENDER, Robert W. LANGLEY, Mary LANGLEY
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Patent number: 7963901Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having a protruding inlet therein. The protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet. The cell separation chamber may have a baffle within a separation area. The baffle may have a plurality of vanes with openings therein.Type: GrantFiled: September 12, 2008Date of Patent: June 21, 2011Assignee: CaridianBCT, Inc.Inventors: Robert W. Langley, John Pittinger, Logan Fender
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Patent number: 7857744Abstract: A cell separation set for separating blood components, having a cell separation chamber with a first entry section having a wall with an outwardly flared curve, the entry section having an axial length and an inmost maximum diameter perpendicular to the axial length, the axial length being greater than the inmost maximum diameter. The cell separation chamber further comprises a separation section having a wall comprising an inward curve. A transition section between the entry section and the separation section has a wall comprising a second inward curve, the second inward curve being different from said first inward curve. The first curve may be tangent to the second curve at a first junction between the first and second curves and the second curve may be tangent to the third curve at a second junction between the second and third curves.Type: GrantFiled: June 19, 2007Date of Patent: December 28, 2010Assignee: CaridianBCT, Inc.Inventors: Robert W. Langley, Linda A. Taylor, Timothy Michael Taga
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Patent number: 7824355Abstract: Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.Type: GrantFiled: August 7, 2008Date of Patent: November 2, 2010Assignee: CaridianBCT, Inc.Inventors: Robert W. Langley, Thomas J. Felt, Geert Van Waeg, Marlene Adele Bainbridge
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Patent number: 7704454Abstract: Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.Type: GrantFiled: October 8, 2003Date of Patent: April 27, 2010Assignee: CaridianBCT, Inc.Inventors: Robert W. Langley, Thomas J. Felt, Geert Van Waeg, Marlene Adele Bainbridge
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Publication number: 20100065483Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having a protruding inlet therein. The protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet. The cell separation chamber may have a baffle within a separation area. The baffle may have a plurality of vanes with openings therein.Type: ApplicationFiled: September 12, 2008Publication date: March 18, 2010Applicant: CARIDIANBCT, INC.Inventors: Robert W. LANGLEY, John PITTINGER, Logan FENDER
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Publication number: 20090043237Abstract: Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.Type: ApplicationFiled: August 7, 2008Publication date: February 12, 2009Applicant: CaridianBCT, Inc.Inventors: Robert W. Langley, Thomas J. Felt, Geert Van Waeg, Marlene Adele Bainbridge
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Publication number: 20080318756Abstract: A cell separation set for separating blood components, having a cell separation chamber with a first entry section having a wall with an outwardly flared curve, the entry section having an axial length and an inmost maximum diameter perpendicular to the axial length, the axial length being greater than the inmost maximum diameter. The cell separation chamber further comprises a separation section having a wall comprising an inward curve. A transition section between the entry section and the separation section has a wall comprising a second inward curve, the second inward curve being different from said first inward curve. The first curve may be tangent to the second curve at a first junction between the first and second curves and the second curve may be tangent to the third curve at a second junction between the second and third curves.Type: ApplicationFiled: June 19, 2007Publication date: December 25, 2008Applicant: GAMBRO BCT, INC.Inventors: Robert W. Langley, Linda A. Taylor, Timothy Michael Taga
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Patent number: 7072769Abstract: A blood component collection system with manipulation and optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.Type: GrantFiled: March 1, 2001Date of Patent: July 4, 2006Assignee: Gambro, Inc.Inventors: Peter Fletcher-Haynes, William Sweat, Richard Judy, Scott Butzke, Kim Pemberton, Frank Corbin, III, Robert W. Langley, Steven Gage Urdahl, Christopher Fletcher
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Publication number: 20010034614Abstract: A blood component collection system with manipulation and optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.Type: ApplicationFiled: March 1, 2001Publication date: October 25, 2001Inventors: Peter Fletcher-Haynes, William Sweat, Richard Judy, Scott Butzke, Kim Pemberton, Frank Corbin, Robert W. Langley, Steven Gage Urdahl, Christopher Fletcher
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Patent number: 6233525Abstract: A blood component collection system is disclosed with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameters. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.Type: GrantFiled: July 26, 1999Date of Patent: May 15, 2001Assignee: Gambro, IncInventors: Robert W. Langley, John J. Keller, Steven Gage Urdahl
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Patent number: 5970423Abstract: A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.Type: GrantFiled: September 12, 1997Date of Patent: October 19, 1999Assignee: Cobe Laboratories, Inc.Inventors: Robert W. Langley, John J. Keller, Steven Gage Urdahl
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Patent number: 5837150Abstract: A method for processing blood in an apheresis system is disclosed. The present invention includes selecting a packing factor for separated blood component types in the separation stage(s) of a blood processing vessel. A packing factor is a number that reflects the degree with which the blood component types are packed together in the separation stage(s) and is dependent at least upon the rotational speed and the flow rate into the blood processing vessel. The method further includes providing an apheresis system and operating it under conditions to separate the blood into a plurality of blood component types and achieve the selected packing factor.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: COBE Laboratories, Inc.Inventors: Robert W. Langley, Brian M. Holmes, Marlene Adele Bainbridge
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Patent number: 5817042Abstract: A method and apparatus for maximizing the total amount of blood processed during an apheresis procedure by optimizing the concentration of anticoagulant in a donor/patient and the associated extracorporeal tubing set is provided. A simplified model of anticoagulant accumulation in a donor/patient's body is used to calculate an optimal anticoagulant infusion rate profile to the donor/patient during a blood processing procedure. A maximum acceptable anticoagulant concentration in the donor/patient acts as an upper limit on the rate at which anticoagulant may be infused to the donor/patient using the optimized infusion rate profile. A minimum acceptable anticoagulant level acts as a lower limit in optimally controlling the anticoagulant concentration in the extracorporeal tubing set.Type: GrantFiled: March 27, 1996Date of Patent: October 6, 1998Assignee: COBE Laboratories, Inc.Inventors: Robert W. Langley, Geert Van Waeg, Larry Joe Dumont
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Patent number: 5712798Abstract: A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.Type: GrantFiled: May 12, 1995Date of Patent: January 27, 1998Assignee: Cobe Laboratories, Inc.Inventors: Robert W. Langley, John J. Keller, Steven Gage Urdahl
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Patent number: 5676645Abstract: A method and apparatus for maximizing the total amount of blood processed during an apheresis procedure by optimizing the concentration of anticoagulant in a donor/patient and the associated extracorporeal tubing set is provided. A simplified model of an anticoagulant accumulation in a donor/patient's body is used to calculate an optimal anticoagulant infusion rate profile to the donor/patient during a blood processing procedure. A maximum acceptable anticoagulant concentration in the donor/patient acts as an upper limit on the rate at which anticoagulant may be infused to the donor/patient using the optimized infusion rate profile. A minimum acceptable anticoagulant level acts as a lower limit in optimally controlling the anticoagulant concentration in the extracorporeal tubing set.Type: GrantFiled: June 6, 1995Date of Patent: October 14, 1997Assignee: COBE Laboratories, Inc.Inventors: Geert Van Waeg, Robert W. Langley, Larry Joe Dumont
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Patent number: 5611997Abstract: An apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield of the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield of the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield may be associated therewith, thereby providing a blood component product.Type: GrantFiled: June 1, 1995Date of Patent: March 18, 1997Assignee: COBE Laboratories, Inc.Inventors: Robert W. Langley, Larry J. Dumont
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Patent number: 5605842Abstract: A method for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield of the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield of the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield may be associated therewith, thereby providing a blood component product.Type: GrantFiled: May 12, 1995Date of Patent: February 25, 1997Assignee: Cobe Laboratories, Inc.Inventors: Robert W. Langley, Larry J. Dumont
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Patent number: 5496265Abstract: A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.Type: GrantFiled: October 21, 1993Date of Patent: March 5, 1996Assignee: Cobe Laboratories, Inc.Inventors: Robert W. Langley, John J. Keller, Steven G. Urdahl
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Patent number: 5447863Abstract: A method and apparatus to concentrate and purify islets of Langerhans from a tissue suspension containing islets and tissue fragments. The tissue suspension is flowed through an inclined channel such that laminar flow is established in the channel. The islets settle toward the channel bottom and are drawn out of the channel through an outlet in the channel bottom, while the remaining tissue suspension flows out a second outlet positioned higher than the islet outlet. Additional concentration or purification may be accomplished by passing the islets through the channel additional times and by centrifuging or filtering operations.Type: GrantFiled: November 2, 1993Date of Patent: September 5, 1995Assignee: COBE Laboratories, Inc.Inventor: Robert W. Langley