Abstract: The invention relates to a rolling bearing, in particular a center-free large rolling bearing, comprising two concentric races, of which one race has a groove open toward the other race and the other race has a lug ring, which engages in said groove, the lug ring being supported on the groove by means of at least two thrust bearings and at least one radial bearing, said axial bearings being designed as roller bearings, all the radial bearings being designed as ball bearings.

Abstract: A rolling bearing having concentric bearing rings supported on one another rotatably with respect to each other by means of at least one row of rolling elements and have bearing races for the rolling elements of the at least one row of rolling elements. The invention further relates to a material transfer- or construction machine, such as a crane or cable excavator, having such a rolling bearing. Providing different bearing race corrections in different angular sectors of the bearing rings and/or providing the bearing race correction only in a fraction of the circumference of the bearing rings is advantageous over the conventional use of a bearing race correction that is constant over the circumference. A bearing race correction that is limited to one sector or that is different from sector to sector, or that is not constant over the circumference, enables the bearing rings to adapt to expected loads.

Abstract: A rolling bearing having concentric bearing rings supported on one another rotatably with respect to each other by means of at least one row of rolling elements and have bearing races for the rolling elements of the at least one row of rolling elements. The invention further relates to a material transfer- or construction machine, such as a crane or cable excavator, having such a rolling bearing. Providing different bearing race corrections in different angular sectors of the bearing rings and/or providing the bearing race correction only in a fraction of the circumference of the bearing rings is advantageous over the conventional use of a bearing race correction that is constant over the circumference. A bearing race correction that is limited to one sector or that is different from sector to sector, or that is not constant over the circumference, enables the bearing rings to adapt to expected loads.

Abstract: An open-centered large rolling bearing having two concentric bearing rings, which are supported against one another in the axial direction of the rolling bearing by means of at least two axial bearings, which are arranged on opposite end faces of a bearing ring. In the radial direction, the bearing rings are supported against one another by at least three radial bearings, which are arranged on inner and outer circumferential sides of a bearing ring.

Abstract: A multi-row rolling bearing having an inner ring and an outer ring and at least two axial rolling bearing rows for supporting axial forces between the inner and outer ring, wherein the two axial rolling bearing rows are seated on opposite axial sides of a radially projecting annular lug which engages in an annular groove and which is supported by means of the axial rolling bearing rows against the annular groove. According to the invention, at least one of the axial rolling bearing rows is formed as an angular-contact roller bearing with an angle of inclination of greater than 0° to at most 45°.

Abstract: The invention relates to a rolling bearing, in particular a center-free large rolling bearing, comprising two concentric races, of which one race has a groove open toward the other race and the other race has a lug ring, which engages in said groove, the lug ring being supported on the groove by means of at least two thrust bearings and at least one radial bearing, said axial bearings being designed as roller bearings, all the radial bearings being designed as ball bearings.

Abstract: An open-centered large rolling bearing having two concentric bearing rings, which are supported against one another in the axial direction of the rolling bearing by means of at least two axial bearings, which are arranged on opposite end faces of a bearing ring. In the radial direction, the bearing rings are supported against one another by at least three radial bearings, which are arranged on inner and outer circumferential sides of a bearing ring.

Abstract: A multi-row rolling bearing having an inner ring and an outer ring and at least two axial rolling bearing rows for supporting axial forces between the inner and outer ring, wherein the two axial rolling bearing rows are seated on opposite axial sides of a radially projecting annular lug which engages in an annular groove and which is supported by means of said axial rolling bearing rows against the annular groove. According to the invention, at least one of the axial rolling bearing rows is formed as an angular-contact roller bearing with an angle of inclination of greater than 0° to at most 45°.

Abstract: The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

Abstract: The present invention relates to a novel derivative of Compound 1 selectively substituted with fluorine and/or deuterium and optionally further substituted with deuterium and 13C elsewhere in the molecule. The compounds of this invention are cholesterol esterase transfer protein inhibitors and possess unique biopharmaceutical and pharmacokinetic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and tissues and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these compounds and methods of treating diseases and conditions that are responsive to inhibition of cholesterol esterase transfer protein, alone and in combination with additional agents.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

Abstract: This invention features a method for modulating human N-type calcium channel ?1B+SFVG subunit activity.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-?-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-?-mediated diseases and decreasing IGIF and IFN-? production using the compounds and compositions of this invention.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.