Patents by Inventor Robert Zelle

Robert Zelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100267697
    Abstract: The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
    Type: Application
    Filed: December 11, 2007
    Publication date: October 21, 2010
    Applicant: Wyeth
    Inventors: Vincent P. Galullo, Robert Zelle, Danielle Soenen, Christopher Todd Baker, Paul Will, Hormoz Mazdiyasni, Jinsong Guo, Andrew Fensome, Jeffrey Curtis Kern, William Jay Moore, Edward George Melenski, Justin Kaplan
  • Publication number: 20100029716
    Abstract: The present invention relates to a novel derivative of Compound 1 selectively substituted with fluorine and/or deuterium and optionally further substituted with deuterium and 13C elsewhere in the molecule. The compounds of this invention are cholesterol esterase transfer protein inhibitors and possess unique biopharmaceutical and pharmacokinetic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and tissues and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these compounds and methods of treating diseases and conditions that are responsive to inhibition of cholesterol esterase transfer protein, alone and in combination with additional agents.
    Type: Application
    Filed: April 10, 2007
    Publication date: February 4, 2010
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Roger Tung, Robert Zelle
  • Patent number: 7547717
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: June 16, 2009
    Assignee: Wyeth
    Inventors: Robert Zelle, Vincent P. Galullo
  • Publication number: 20090012095
    Abstract: This invention features a method for modulating human N-type calcium channel ?1B+SFVG subunit activity.
    Type: Application
    Filed: April 29, 2008
    Publication date: January 8, 2009
    Applicant: Wyeth
    Inventors: Robert Zelle, Pravin Chaturvedi
  • Publication number: 20080293722
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 15, 2005
    Publication date: November 27, 2008
    Applicant: Wyeth
    Inventors: Robert Zelle, Christopher Todd Baker, Paul Will, Vincent P. Galullo
  • Publication number: 20080242716
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: October 2, 2008
    Inventors: Robert Zelle, Christopher T. Baker
  • Publication number: 20080139560
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: June 12, 2008
    Inventors: Robert Zelle, Vincent P. Galullo
  • Patent number: 7368467
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: May 6, 2008
    Assignee: Wyeth
    Inventors: Robert Zelle, Vincent P. Galullo, Hormoz Mazdiyasni
  • Publication number: 20080090891
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: December 12, 2007
    Publication date: April 17, 2008
    Applicant: Wyeth
    Inventors: Robert Zelle, Vincent Galullo, Hormoz Mazdiyasni
  • Publication number: 20080039449
    Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-?-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-?-mediated diseases and decreasing IGIF and IFN-? production using the compounds and compositions of this invention.
    Type: Application
    Filed: January 18, 2007
    Publication date: February 14, 2008
    Inventors: Mark Batchelor, David Bebbington, Guy Bemis, Wolf Fridman, Roger Gillespie, Julian Golec, David Lauffer, David Livingston, Saroop Matharu, Michael Mullican, Mark Murcko, Robert Murdoch, Robert Zelle
  • Publication number: 20070281937
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: December 6, 2007
    Inventors: Robert Zelle, Vincent Galullo, Christopher Baker, Paul Will, William Frazee, Hormoz Mazdiyasni, Jinsong Guo
  • Publication number: 20070208070
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: September 6, 2007
    Inventors: Robert Zelle, Vincent Galullo
  • Publication number: 20070208064
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: September 6, 2007
    Applicant: Wyeth
    Inventors: Robert Zelle, Vincent Galullo, Paul Will
  • Publication number: 20070203194
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein cab be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 30, 2007
    Applicants: SCION PHARMACEUTICALS, INC., WYETH
    Inventors: Robert Zelle, Vincent Galullo, Christopher Baker, Paul Will, William Frazee
  • Publication number: 20070197619
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 23, 2007
    Inventors: Robert Zelle, Paul Will
  • Publication number: 20070197513
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 23, 2007
    Inventor: Robert Zelle
  • Publication number: 20070191448
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 16, 2007
    Inventors: Robert Zelle, Vincent Galullo
  • Publication number: 20050203159
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: March 7, 2005
    Publication date: September 15, 2005
    Inventors: Robert Zelle, Vincent Galullo, Hormoz Mazdiyasni
  • Publication number: 20050143436
    Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-?-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-?-mediated diseases and decreasing IGIF and IFN-? production using the compounds and compositions of this invention.
    Type: Application
    Filed: November 29, 2004
    Publication date: June 30, 2005
    Inventors: Mark Batchelor, David Bebbington, Guy Bemis, Wolf Fridman, Roger Gillespie, Julian Golec, David Lauffer, David Livingston, Saroop Matharu, Michael Mullican, Mark Murcko, Robert Murdoch, Robert Zelle
  • Publication number: 20040204404
    Abstract: This invention features a method for modulating human N-type calcium channel &agr;1B+SFVG subunit activity.
    Type: Application
    Filed: September 29, 2003
    Publication date: October 14, 2004
    Inventors: Robert Zelle, Pravin Chaturvedi