Patents by Inventor Roberto Romero

Roberto Romero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10802030
    Abstract: Provided are systems and methods to identify subjects at risk for preterm labor and/or preterm birth. The systems and methods utilize biomarkers. Also provided are systems and methods for decreasing the risk of preterm labor by administering a treatment following a positive risk identification.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: October 13, 2020
    Assignees: Wayne State University, The United States of America as Represented by the Secretary, Department of Health and Human Service
    Inventors: Adi L. Tarca, Offer Erez, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Patent number: 10670610
    Abstract: Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: June 2, 2020
    Assignees: Wayne State University, The United States of America as represented by The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health, Semmelweis University, Genesis Theranostix Korlatolt Felelossegu Tarsasag
    Inventors: Adi L. Tarca, Nandor Than, Gabor Juhasz, Adrienna Katalin Kekesi, Hamutal Meiri, Zoltan Papp, Roberto Romero
  • Patent number: 10561673
    Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: February 18, 2020
    Assignees: Wayne State University, The United States of America as Represented by the Secretary, Department of Health and Human Service
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra S Navath, Hui Dai, Anupa R. Menjoge
  • Publication number: 20200029570
    Abstract: It relates to compositions produced by microorganism cell cultures, including microorganism-free compositions as well as compositions comprising inactivated microorganisms. It also relates to methods for obtaining the compositions produced by microorganism cell cultures and to agricultural compositions comprising them. It also relates to the use of the compositions of the invention as plant growth promoting agents and to methods for promoting stimulatory activity on plants comprising administering to the plant with these compositions.
    Type: Application
    Filed: April 3, 2017
    Publication date: January 30, 2020
    Inventors: Carol Paola BEJARANO TOVAR, Pedro Roberto MOLINA GUEVARA, Nerea FERNÁNDEZ ORTIZ DE JÓCANO, Xana Melissa BELASTEGUI MACADAM, Abdellatif BAHAJI, Angela Maria SÁNCHEZ LÓPEZ, Miren Edurne BAROJA FERNÁNDEZ, Francisco José MUÑOZ PÉREZ, Javier POZUETA ROMERO
  • Publication number: 20190285643
    Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
    Type: Application
    Filed: April 17, 2019
    Publication date: September 19, 2019
    Applicants: Wayne State University, The United States of America as Represented by the Secretary, Department of Health and Human Service
    Inventors: Tinnakorn Chaiworapongsa, Roberto Romero, Sonia S. Hassan
  • Publication number: 20190247407
    Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
    Type: Application
    Filed: December 18, 2018
    Publication date: August 15, 2019
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra S Navath, Hui Dai, Anupa R. Menjoge
  • Patent number: 10281475
    Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 7, 2019
    Assignees: Wayne State University, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Patent number: 10172951
    Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: January 8, 2019
    Assignees: Wayne State University, The United States of America as Represented by the Secretary, Department of Health and Human Service
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra S. Navath, Hui Dai, Anupa R. Menjoge
  • Publication number: 20180328937
    Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.
    Type: Application
    Filed: November 7, 2016
    Publication date: November 15, 2018
    Applicants: WAYNE STATE UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE
    Inventors: Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Publication number: 20180321250
    Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMD-H1 and/or PGAM1, as markers of true labor.
    Type: Application
    Filed: November 7, 2016
    Publication date: November 8, 2018
    Applicants: WAYNE STATE UNIVERSITY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN
    Inventors: Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Publication number: 20180306803
    Abstract: Provided are systems and methods to identify subjects at risk for preterm labor and/or preterm birth. The systems and methods utilize biomarkers. Also provided are systems and methods for decreasing the risk of preterm labor by administering a treatment following a positive risk identification.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 25, 2018
    Inventors: Adi L. Tarca, Offer Erez, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Publication number: 20170242021
    Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
    Type: Application
    Filed: March 27, 2015
    Publication date: August 24, 2017
    Inventors: Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Publication number: 20170028075
    Abstract: Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the PAMAM dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel is formed as small crosslinked particles in the size range 25 nm to 10 ?m and is suitable for injectable delivery of hydrogel or ocular delivery for the purpose of therapeutic treatment and imaging.
    Type: Application
    Filed: September 27, 2016
    Publication date: February 2, 2017
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra Navath, Anupa Menjoge
  • Patent number: 9526794
    Abstract: The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: December 27, 2016
    Assignees: Wayne State University, National Institutes of Health
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra Navath, Anupa Menjoge
  • Publication number: 20160187347
    Abstract: Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers.
    Type: Application
    Filed: June 13, 2013
    Publication date: June 30, 2016
    Applicants: WAYNE STATE UNIVERSITY, The United States of America as represented by the Secretary, Dept. of Health and Human Services, SEMMELWEIS UNIVERSITY, GENESIS THERANOSTIX KORLATOLT FELELOSSEGU TARSASAG
    Inventors: Adi L. TARCA, Nandor THAN, Gabor JUHASZ, Adrienna Katalin KEKESI, Hamutal MEIRI, Zoltan PAPP, Roberto ROMERO
  • Publication number: 20150190112
    Abstract: Described is an apparatus and method for fetal intelligent navigation echocardiography (FINE). Use of this apparatus and method allows for visualization of standard fetal echocardiography views from dataset volumes obtained with spatiotemporal image correlation (STIC) and application of intelligent navigation technology. An imaging system includes a processor that executes an instruction set that causes the computing system to perform operations comprising: obtaining dataset volumes of a heart, placing markers within the dataset, and generating selected images of the heart based on the markers in the dataset. The imaging system also includes a memory for storing the images, and a display for displaying the images. The imaging system further includes a port communicatively coupled to a network.
    Type: Application
    Filed: September 8, 2013
    Publication date: July 9, 2015
    Inventors: Lami Yeo, Roberto Romero, Gustavo Eduardo Abella, Ricardo Enrique Gayoso
  • Publication number: 20150141350
    Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
    Type: Application
    Filed: September 4, 2014
    Publication date: May 21, 2015
    Inventors: Rangaramanujam M. Kannan, Sujatha Kannan, Roberto Romero, Raghavendra S. Navath, Hui Dai, Anupa R. Menjoge
  • Publication number: 20140367311
    Abstract: Alumina support compositions comprising at least 0.1 wt % of silica are disclosed. The alumina support are characterized by a pore volume of greater than 0.60 cc/g, a median pore size ranging from about 70 to about 120, a pore size distribution such that at least 90% of the total pore volume falls within the range of about 20 to about 250, and a pore size distribution width of no less than about 40. Alumina compositions of the present invention exhibit a primary peak mode at a pore diameter less than the median pore diameter. Also provided are catalysts made from the alumina supports, and processes of preparing and using the supports and catalysts.
    Type: Application
    Filed: November 20, 2012
    Publication date: December 18, 2014
    Applicant: Advanced Refining Technologies LLC
    Inventors: Xianghua Yu, Bruno C. Nesci, Roberto Romero, Gill M. Malick, Jifei Jia, Cecelia A. Radlowski
  • Patent number: 8889101
    Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: November 18, 2014
    Assignee: Wayne State University
    Inventors: Rangaramanujam M. Kannan, Sujatha Kannan, Roberto Romero, Raghavendra S. Navath
  • Patent number: 8732857
    Abstract: Systems, methods and computer program products for controlling access to electronic content on a client device are provided. Whether access to electronic content is allowed or blocked is based on information and processes performed at the client device. Controlling access to electronic content on a client device can involve locally determining whether access to the electronic content will be allowed, blocked, or will depend upon further analysis performed by a remote device, such as a server. If a webpage is requested, for example, a client device may compare the URL address of the requested webpage, along with keywords and phrases found on the webpage, to locally-stored updateable lists of banned URL addresses and banned keywords and phrases to determining whether access to the electronic content will be allowed, blocked, or will depend upon further analysis.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: May 20, 2014
    Assignee: Sosvia, Inc.
    Inventors: Fermin Otniel Garcia, Roberto Romero Saldivar