Patents by Inventor Robertus Antonius Mijndert Van Der Hoeven

Robertus Antonius Mijndert Van Der Hoeven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180070622
    Abstract: The present invention relates to a steviol glycoside having the formula of (I) wherein at least 3 sugar moieties are present at positions R1 and at least three sugar moieties are present at position R2 and wherein the steviol glycoside comprises at least seven sugar moieties all of which are linked, directly or indirectly, to the steviol aglycon by ?-linkages.
    Type: Application
    Filed: April 4, 2016
    Publication date: March 15, 2018
    Inventors: Robertus Antonius Mijndert VAN DER HOEVEN, Peter Philip LANKHORST, Silvia GOSIEWSKA
  • Publication number: 20170191091
    Abstract: The present invention relates to a recombinant cell which is capable of producing one or more of itaconic acid, 4-methyl itaconate or 1-methyl itaconate, wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans-aconitate methyltransferase. A recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: —a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and —one or more nucleic acids encoding polypeptides which separately or together catalyze a reaction towards acetyl CoA, wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans-aconitate methyltransferase. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.
    Type: Application
    Filed: May 28, 2015
    Publication date: July 6, 2017
    Inventors: Zheng ZHAO, Bernard MEIJRINK, Robertus Antonius Mijndert VAN DER HOEVEN, Liang WU, Johannes Andries ROUBOS, Marina VAN GELDER
  • Publication number: 20160153017
    Abstract: The present invention relates to a recombinant microorganism whereby expression of nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least rebaudioside M. Such a recombinant microorganism may be used in a method of production of rebaudioside M.
    Type: Application
    Filed: July 15, 2014
    Publication date: June 2, 2016
    Inventors: Robertus Antonius Mijndert VAN DER HOEVEN, Igor GALAEV, Viktor Marius BOER
  • Publication number: 20150291986
    Abstract: The present invention relates to a recombinant yeast cell which is capable of producing one or more of 4-methyl itaconate or 1-methyl itaconate. The invention also relates to a recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and a nucleic acid encoding a polypeptide which catalyzes a reaction towards acetyl CoA. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.
    Type: Application
    Filed: November 25, 2013
    Publication date: October 15, 2015
    Inventors: Zheng Zhao, Bernard Meijrink, Robertus Antonius Mijndert Van Der Hoeven, Liang Wu, Johannes Andries Roubos
  • Patent number: 8945898
    Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: February 3, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
  • Publication number: 20140206036
    Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
    Type: Application
    Filed: September 9, 2013
    Publication date: July 24, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Luppo EDENS, Robertus Antonius Mijndert VAN DER HOEVEN, Andre Leonardus DE ROOS, Melissa HARVEY
  • Patent number: 8524225
    Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: September 3, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Luppo Edens, Melissa Harvey, Robertus Antonius Mijndert Van Der Hoeven, Andre Leonardus De Roos
  • Publication number: 20130144034
    Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.
    Type: Application
    Filed: July 1, 2011
    Publication date: June 6, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
  • Publication number: 20110142987
    Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
    Type: Application
    Filed: October 18, 2010
    Publication date: June 16, 2011
    Applicant: DSM IP Assets B.V.
    Inventors: Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Andre Leonardus De Roos, Melissa Harvey
  • Patent number: 7608697
    Abstract: A method of enzymatically producing a protein hydrolysate from a protein substrate is described, wherein a proline-specific endoprotease or a composition containing a proline-specific endoprotease and optionally a subtilisin or a metallo endoprotease, and other enzymes such as carboxypeptidases, is used to produce a protein hydrolysate enriched in peptide fragments having a carboxy terminal proline residue. Such protein hydrolysates may be used as such or to reduce bitterness in foods nutritionally supplemented by protein hydrolysates, as well as to produce hydrolysate containing foodstuffs having low antigenicity.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: October 27, 2009
    Assignee: DSM IP Assets B.V.
    Inventors: Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Veronique Delest
  • Patent number: 7309595
    Abstract: The present invention provides An isolated polypeptide which has proline specific endoprotease activity, selected from the group consisting of:(a) a polypeptide which has an amino acid sequence which has at least 40% amino acid sequence identity with amino acids 1 to 526 of SEQ ID NO:2 or a fragment thereof;(b) a polypeptide which is encoded by a polynucleotide which hybridizes under low stringency conditions with (i) the nucleic acid sequence of SEQ ID NO:1 or a fragment thereof which is at least 80% or 90% identical over 60, preferably over 100 nucleotides, more preferably at least 90% identical over 200 nucleotides, or (ii) a nucleic acid sequence complementary to the nucleic acid sequence of SEQ ID NO:1.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: December 18, 2007
    Assignee: DSM IP Assets B.V.
    Inventors: Petrus Jacobus Theodorus Dekker, Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Linda De Lange
  • Publication number: 20070207944
    Abstract: The present invention describes a process to produce IPP from a protein source whereby the ratio of IPP and VPP produced from the protein is at least 5, preferably at least 10 and more preferably at least 20, which comprises the use of a proline specific endoprotease.
    Type: Application
    Filed: July 12, 2005
    Publication date: September 6, 2007
    Inventors: Luppo Edens, Andre Leonardus De Roos, Robertus Antonius Mijndert Van Der Hoeven, Philippus Antonius Deen
  • Publication number: 20040241664
    Abstract: The present invention provides An isolated polypeptide which has proline specific endoprotease activity, selected from the group consisting of:(a) a polypeptide which has an amino acid sequence which has at least 40% amino acid sequence identity with amino acids 1 to 526 of SEQ ID NO:2 or a fragment thereof;(b) a polypeptide which is encoded by a polynucleotide which hybridizes under low stringency conditions with (i) the nucleic acid sequence of SEQ ID NO:1 or a fragment thereof which is at least 80% or 90% identical over 60, preferably over 100 nucleotides, more preferably at least 90% identical over 200 nucleotides, or (ii) a nucleic acid sequence complementary to the nucleic acid sequence of SEQ ID NO:1.
    Type: Application
    Filed: November 10, 2003
    Publication date: December 2, 2004
    Inventors: Petrus Jacobus Theodorus Dekker, Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Linda De Lange