Patents by Inventor Roel Penterman

Roel Penterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140087361
    Abstract: The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.
    Type: Application
    Filed: April 30, 2012
    Publication date: March 27, 2014
    Inventors: Irene Dobbelaer, Sieglinde Neerken, Paul Van De Wiel, Bart Van Meerbergen, Roel Penterman
  • Publication number: 20130299015
    Abstract: The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
    Type: Application
    Filed: January 20, 2012
    Publication date: November 14, 2013
    Inventors: Roel Penterman, Johannes Van Eemeren, Reinhold Wimberger-Friedl, Henrik Van Amerongen
  • Publication number: 20130171615
    Abstract: Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Application
    Filed: December 7, 2010
    Publication date: July 4, 2013
    Applicant: BIOCARTIS SA
    Inventors: Bart Edward Jozef Gusta Van Meerbergen, Oana Mihaela Piciu, Ron Gill, Kristiane Anne Schmidt, Sieglinde Neerken, Marc Wilhelmus Gijsbert Ponjee, Zeynep Seflek, Roel Penterman, Paul Arnold Van De Wiel
  • Patent number: 8475736
    Abstract: The present invention provides a microfluidic device, for instance for molecular sieving or for detecting a target substance in a sample fluid. The device comprises a first substrate (120) having a substantially flat first surface that is provided with first recesses (124), and a second substrate (128) having a substantially flat second surface that is provided with second recesses (130). At least some of the first recesses are filled with a porous material (114). Alternate first recesses and second recesses form a meandering channel for a sample fluid. The second recesses may be filled with a further porous material. In an embodiment, a capture substance for binding a target substance is arranged in or on the porous material.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: July 2, 2013
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Reinhold Wimberger-Friedl, Roel Penterman, Ralph Kurt, Emiel Peeters
  • Publication number: 20130141726
    Abstract: The invention relates to a sensing device (1) for detecting a substance (3) in a fluid (6), wherein the sensing device (1) comprises a sensing region (2) for being used for generating a sensing signal depending on the substance, a reference region (4) for being used for providing a reference signal, and a reference element (5) covering the reference region (4). The reference element (5) is adapted to shield the reference region (4) from the substance (3) and to allow the fluid (6) to penetrate the reference element (5). This reduces the influence of the reference signal by the substance (3) and, since the reference element (5) is adapted to allow the fluid (6) to penetrate the reference element (5), differences regarding properties of the fluid (6) at the sensing region (2) and of the reference element (5) at the reference region (4) can be reduced. This reduction leads to an improved reference signal, which can be used, for example, for correcting the sensing signal.
    Type: Application
    Filed: April 26, 2011
    Publication date: June 6, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Ron Martinus Laurentius Van Lieshout, Roel Penterman
  • Patent number: 8382339
    Abstract: A light output device comprises at least one light source having a light source output comprising at least a light output, and a switchable member through which the light output is provided, and which is switchable between at least two optical states. These at least two optical states provide different levels of uniformity of the light output. The switching of the switchable member is induced by the light source output.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: February 26, 2013
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Maarten Marinus Johannes Wilhelmus Van Herpen, Roel Penterman
  • Publication number: 20120266986
    Abstract: A microfluidic cartridge for placement onto a parallel pneumatic interface plate of a pneumatic instrument is provided. The cartridge includes a three dimensional fluid channel, in which a fluid is to be transported, a flexible membrane that spans a plane and is part of an outer surface of the cartridge. The three dimensional fluid channel is spatially defined in three dimensions by internal walls of the cartridge and by the flexible membrane. The flexible membrane is in a ground state, when no pressure or vacuum is applied to the flexible membrane. However, the flexible membrane is pneumatically deflectable from the ground state perpendicular to the plane of the flexible membrane in two directions when the cartridge is placed onto the parallel pneumatic interface plate.
    Type: Application
    Filed: October 6, 2010
    Publication date: October 25, 2012
    Applicant: BIOCARTIS SA
    Inventors: Reinhold Wimberger-Friedl, Roel Penterman, Hendrik Halling Van Amerongen, Theodorus Antonius Johannes Loring, Martijn Jochem Van Uden
  • Publication number: 20120190793
    Abstract: The present invention relates to a method for the production of scaffold materials and/or scaffolds for tissue and/or organ engineering, said method comprising the addition of at least one anchoring unit for a labelling agent, to at least one scaffold material and/or to at least one scaffold.
    Type: Application
    Filed: November 19, 2009
    Publication date: July 26, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: David Halter, Ralph Kurt, Emiel Peeters, Roel Penterman, Dirk Jan Broer, Rudolf Mathias Johannes Nicolaas Lamerichs
  • Publication number: 20120126154
    Abstract: The invention relates to a valve (2) for controlling a passage of particles from a first region (6) to a second region (7), wherein the valve (2) comprises a valve material (4) having a modifiable degree of penetrability and a valve region (16) comprising the valve material (4), wherein the valve region (16) and the valve material (4) are adapted such that the particles have to penetrate the valve material (4) if the particles pass the valve (2) for being transferred from the first region (6) to the second region (7). The degree of opening of the valve (2) can easily be controlled by modifying the degree of penetrability of the valve material (4), for example, by modifying the temperature of the valve material (4). Moreover, by penetrating the valve material (4) the particles can be separated from other elements like a fluid containing the particles.
    Type: Application
    Filed: June 2, 2010
    Publication date: May 24, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Remco Christian Den Dulk, Roel Penterman, Menno Willem Jose Prins
  • Publication number: 20110293712
    Abstract: The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.
    Type: Application
    Filed: November 26, 2009
    Publication date: December 1, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Ralph Kurt, Emiel Peeters, Roel Penterman, Dirk J. Broer, David Halter
  • Publication number: 20110243852
    Abstract: The present invention is related to scaffolds for tissue engineering and organ engineering. More particularly, the present invention is related to a method for the production of a labelled scaffold for tissue and/or organ engineering comprising a reactive fluorinated surfactant, which serve as imaging label for medical imaging means, like CT, MRI, PET, scintigraphy and/or ultrasound imaging and the like.
    Type: Application
    Filed: December 7, 2009
    Publication date: October 6, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Emiel Peeters, David Halter, Dirk Jan Broer, Roel Penterman
  • Publication number: 20110165671
    Abstract: The present invention is related to a process for providing an assembly of cell microcarriers, comprising the steps of providing planar, two-dimensional objects having two sides (“flakes”), wherein these objects comprise a material which, upon application of an extrinsic stimulus, is transferred from the planar state into a rolled state, providing cells on one side of said flakes (“cell-bearing side”), transferring the flakes from the planar state into a rolled state (“cell wrap”) by application of said extrinsic stimulus, and coupling at least one type of binding agent to the flakes.
    Type: Application
    Filed: June 26, 2009
    Publication date: July 7, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: David Halter, Emiel Peeters, Roel Penterman, Ralph Kurt, Dirk Jan Broer
  • Publication number: 20110095756
    Abstract: The application is directed to a sensor element for use in a magnetochemical sensor, which comprises a first gel-like material (10), especially a swellable hydrogel such as polyacrylamide, and a magnetic second material (20) in the form of particles, especially magnetite (Fe304) nanoparticles, embedded in the first material along with a receptor for an alalyte, eg glucose. Changes in magnetic field due to interaction with the analyte are detected with GMR element (50). Applications include biosensors, DNA testing devices, and high throughput screening.
    Type: Application
    Filed: November 24, 2006
    Publication date: April 28, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Michel Paul Barbara Van Bruggen, Mischa Megens, Hans Van Zon, Ralph Kurt, Roel Penterman, Emiel Peeters
  • Publication number: 20110071051
    Abstract: The present invention relates to a bio chip for fractionating and detecting analytes, such as proteins, protein-complexes, metabolites, glycoproteins, peptides, DNA, RNA, lipids, fatty acids, carbohydrates and/or other ampholytes.
    Type: Application
    Filed: May 19, 2009
    Publication date: March 24, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: David Halter, Ralph Kurt, Roel Penterman, Emiel Peeters, Dirk Jan Broer
  • Publication number: 20110071036
    Abstract: The present invention relates to an isoelectric focusing biochip, in particular for fractionating, detecting and/or collecting analytes, such as proteins, metabolites, glycoproteins and/or peptides, a method for fractionating, detecting and/or collecting analytes, with such a biochip and a manufacturing method for such a biochip.
    Type: Application
    Filed: May 18, 2009
    Publication date: March 24, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Roel Penterman, Christopher James Backhouse
  • Publication number: 20110070469
    Abstract: A micro system power supply (1) comprises a compartment (7), at least one ion sink void (51, 52) being separated from the compartment (7) by ion pervious separation means (61, 62), a first electrode (41) being arranged in the ion sink void, and a second electrode (42). Such a micro system power supply (1) allows to provide power for a micro system, such as, e.g., an implantable micro device, a MEMS, a bioMEMS, or the like, wherein the micro system power supply (1) can be comparably efficiently manufactured in a manner to be comparably environmentally friendly disposable.
    Type: Application
    Filed: May 19, 2009
    Publication date: March 24, 2011
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Dirk Jan Broer, Roel Penterman, Emiel Peeters, Ralph Kurt, David Halter, Hendrik De Koning
  • Patent number: 7847885
    Abstract: A mechanical structure comprises an element which is moveable by nonmechanical means, such as heat or radiation, between a first state having a first shape and a second state having a second shape different. To this end, the element includes a layer of oriented polymerized liquid crystal which exhibits an anisotropic expansion when subjected to such means. In order to facilitate manufacture the element is positioned on a substrate which has a region of high adhesiveness and a region of low adhesiveness for polymerized liquid crystal. To manufacture such structures a layer of oriented polymerizable liquid crystal is formed on a substrate (201) which is provided with a patterned surface that provides adhesive regions (204) with high adhesiveness to polymerized liquid crystal and nonadhesive regions (203) with low adhesiveness to polymerized liquid crystal.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: December 7, 2010
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Dirk Jan Broer, Christiane Maria Rosette De Witz, Grietje Neeltje Mol, Roel Penterman
  • Publication number: 20100272608
    Abstract: Embodiments of the invention relates to a temperature sensor and an analytical device comprising the same. The temperature sensor comprises a carrier (11) with a detection surface (12) on which temperature indicating agents (14) are present and, optionally, at which target components can collect and optionally bind to specific capture elements. An incident light beam (L1) is transmitted into the carrier and evanescent wave excitation is induced at the detection surface (12). The amount of light in the reflected light beam (L2) or an optical, e.g. luminescence response is then detected by a light detector (31). In one example, evanescent light is affected (absorbed, scattered) by temperature indicating agents and optionally target components and/or label particles at the binding surface (12) and will therefore be missing in a frustrated total internal reflected light beam (L2).
    Type: Application
    Filed: November 17, 2008
    Publication date: October 28, 2010
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Roel Penterman, Steven Van Lierop, Albert Hendrik Jan Immink, Dirk Jan Broer
  • Publication number: 20100266450
    Abstract: The present invention provides a microf luidic device, for instance for molecular sieving or for detecting a target substance in a sample fluid. The device comprises a first substrate (120) having a substantially flat first surface that is provided with first recesses (124), and a second substrate (128) having a substantially flat second surface that is provided with second recesses (130). At least some of the first recesses are filled with a porous material (114). Alternate first recesses and second recesses form a meandering channel for a sample fluid. The second recesses may be filled with a further porous material. In an embodiment, a capture substance for binding a target substance is arranged in or on the porous material.
    Type: Application
    Filed: December 8, 2008
    Publication date: October 21, 2010
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Reinhold Wimberger-Friedl, Roel Penterman, Ralph Kurt, Emiel Peeters
  • Publication number: 20100265707
    Abstract: A light output device comprises at least one light source having a light source output comprising at least a light output, and a switchable member through which the light output is provided, and which is switchable between at least two optical states. These at least two opticalstates provide different levels of uniformity of the light output. The switching of the switchable member is induced by the light source output.
    Type: Application
    Filed: October 30, 2008
    Publication date: October 21, 2010
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Maarten Marinus Johannes Wilhelmus Van Herpen, Roel Penterman