Patents by Inventor Rogelio P. Frutos

Rogelio P. Frutos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240083889
    Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.
    Type: Application
    Filed: August 24, 2023
    Publication date: March 14, 2024
    Inventors: Katrin BAER, Gisela BODENBACH, Jack Delbert BROWN, Rosemarie Karoline COLLET, Daniel HERKOMMER, Rogelio P. FRUTOS, Joe Ju GAO, Julia Regina GRIMM, Sandra KOCH, Sonia RODRIGUEZ, Svetlana SEHL-OLLENBERGER, Joshua Daniel SIEBER, Thomas G. TAMPONE, Ulrich THEIS, Dirk WEBER, Erik WEIS, Anke WILD
  • Patent number: 10745411
    Abstract: Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: August 18, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Pascale Arielle Jane-Josee Pouzet, Peter Nickolaus, Ulrike Werthmann, Rogelio P. Frutos, Bing-Shiou Yang, Soojin Kim, Jason Alan Mulder, Nitinchandra D. Patel, Chris Hugh Senanayake, Thomas Gabriel Tampone, Xudong Wei
  • Publication number: 20200048278
    Abstract: Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Application
    Filed: October 11, 2019
    Publication date: February 13, 2020
    Inventors: Pascale Arielle Jane-Josee POUZET, Peter NICKOLAUS, Ulrike WERTHMANN, Rogelio P. FRUTOS, Bing-Shiou YANG, Soojin KIM, Jason Alan MULDER, Nitinchandra D. PATEL, Chris Hugh SENANAYAKE, Thomas Gabriel TAMPONE, Xudong WEI
  • Publication number: 20180072754
    Abstract: Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 15, 2018
    Inventors: Pascale Arielle Jane-Josee POUZET, Peter NICKOLAUS, Ulrike WERTHMANN, Rogelio P. FRUTOS, Bing-Shiou YANG, Soojin KIM, Jason Alan MULDER, Nitinchandra D. PATEL, Chris Hugh SENANAYAKE, Thomas Gabriel TAMPONE, Xudong WEI
  • Patent number: 9802954
    Abstract: Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: October 31, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Pascale A. J. Pouzet, Peter Nickolaus, Ulrike Werthmann, Rogelio P. Frutos, Bing-Shiou Yang, Soojin Kim, Jason Alan Mulder, Nitinchandra D. Patel, Chris Hugh Senanayake, Thomas Gabriel Tampone, Xudong Wei
  • Publication number: 20170008903
    Abstract: Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Application
    Filed: August 9, 2013
    Publication date: January 12, 2017
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Pascale A.J. POUZET, Peter NICKOLAUS, Ulrike WERTHMANN, Rogelio P. FRUTOS, Bing-Shiou YANG, Soojin KIM, Jason Alan MULDER, Nitinchandra D. PATEL, Chris Hugh SENANAYAKE, Thomas Gabriel TAMPONE, Xudong WEI
  • Patent number: 9150586
    Abstract: The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: October 6, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Pascale A. J. Pouzet, Peter Nickolaus, Ulrike Werthmann, Rogelio P. Frutos, Bing-Shiou Yang, Soojin Kim, Jason Alan Mulder, Nitinchandra Patel, Chris H. Senanayake, Thomas G. Tampone, Xudong Wei
  • Publication number: 20150148322
    Abstract: The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Application
    Filed: March 15, 2012
    Publication date: May 28, 2015
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Pascale A.J. Pouzet, Peter Nickolaus, Ulrike Werthmann, Rogelio P. Frutos, Bing-Shiou Yang, Soojin Kim, Jason Alan Mulder, Nitinchandra Patel, Chris H. Senanayake, Thomas G. Tampone, Xudong Wei
  • Publication number: 20150045376
    Abstract: Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Application
    Filed: August 9, 2013
    Publication date: February 12, 2015
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Pascale A.J. POUZET, Peter NICKOLAUS, Ulrike WERTHMANN, Rogelio P. FRUTOS, Bing-Shiou YANG, Soojin KIM, Jason Alan MULDER, Nitinchandra D. PATEL, Chris Hugh SENANAYAKE, Thomas Gabriel TAMPONE, Xudong WEI
  • Patent number: 8471010
    Abstract: The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: June 25, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rogelio P. Frutos, Thomas G. Tampone, Jason Alan Mulder, Dhileepkumar Krishnamurthy, Chris H. Senanayake
  • Patent number: 6458986
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-&agr;]imidazol-2-one (1): This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment or prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: October 1, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Patent number: 6441183
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo [1,2-&agr;]imidazol-2-one (1): This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment or prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: August 27, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Patent number: 6437148
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one (1): This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment or prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: August 20, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Patent number: 6433183
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-&agr;]imidazol-2-one (1): This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment or prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: August 13, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Publication number: 20020087009
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1 ,2-a]imidazol-2-one (1): 1
    Type: Application
    Filed: February 15, 2002
    Publication date: July 4, 2002
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Patent number: 6414161
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl- 1-H-imidazo[ 1 ,2-a]imidazol-2-one (1): This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment of prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: July 2, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Publication number: 20020082441
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one (1): 1
    Type: Application
    Filed: February 15, 2002
    Publication date: June 27, 2002
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Publication number: 20020072615
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one (1): 1
    Type: Application
    Filed: February 15, 2002
    Publication date: June 13, 2002
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Publication number: 20020072610
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one (1): 1
    Type: Application
    Filed: February 15, 2002
    Publication date: June 13, 2002
    Inventors: Rogelio P. Frutos, Michael Dale Johnson
  • Publication number: 20020028949
    Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-&agr;]imidazol-2-one (1): 1
    Type: Application
    Filed: July 31, 2001
    Publication date: March 7, 2002
    Inventors: Rogelio P. Frutos, Michael Dale Johnson