Abstract: The invention relates to novel pyridine derivatives which have a fused 5,6, or 7-membered saturated hydrocarbon ring adjacent to the nitrogen of the pyridine ring, and a group X situated on said hydrocarbon ring and separated by one carbon atom from the pyridine nitrogen atom, said group X is cyano, CONHR.sup.3, CSNHR.sup.3 or CO.sub.2 R.sup.5 wherein R.sup.3 is selected from hydrogen, lower alkyl and lower aralkyl radicals and R.sup.5 is selected from hydrogen, lower alkyl and lower aralkyl radicals which may be substituted by alkyl, alkoxy, halogen, nitro or trifluoromethyl; other substituents may be present. Compounds wherein X is CSNHR.sup.3 are anti-ulcer agents and the other compounds are intermediates therefor.

Abstract: The invention relates to novel cyclopentena[b,e]pyridine derivatives which have a thioamide group in the 7-position. The compounds are anti-ulcer agents.

Abstract: The invention provides 5,6,7,8-tetrahydroquinoline derivatives which are substituted at the 8-position by the group NHCSNHR.sup.5 where R.sup.5 is lower alkanoyl or aroyl. These compounds are intermediates for corresponding compounds where R.sup.5 is hydrogen, such compounds being anti-ulcer agents.This application is a continuation-in-part of our copending U.S. application Ser. No. 554,259 filed Feb. 28, 1975, now U.S. Pat. No. 3,991,065.

Abstract: The invention relates to pharmaceutical compositions containing 5,6,7,8-tetrahydroquinoline-8-thioamides and nitriles and related tricyclic compounds and methods of treating ulcers using said compounds.

Abstract: The invention relates to novel cyclopenteno[b]pyridine derivatives which have a thioamide group in the 7-position and related tricyclic compounds. The compounds are anti-ulcer agents.

Abstract: The invention relates to novel cyclopenteno[b]pyridine derivatives which have a group X on the 7-position and related tricyclic compounds. X is CONHR.sup.3, or CO.sub.2 R.sup.5 wherein R.sup.3 is hydrogen or lower alkyl and R.sup.5 is hydrogen or a lower alkyl or lower aralkyl group which may be substituted by alkyl, alkoxy, halogen, nitro or trifluoromethyl; other substituents may be present. The compounds are intermediates for compounds wherein X is CSNHR.sup.3 which are anti-ulcer agents.

Abstract: The invention relates to novel 8-cyano-5,6,7,8-tetrahydroquinoline derivatives which are intermediates for the preparation of corresponding 8-thioamides. Some of the 8-cyano compounds are anti-ulcer agents.

Abstract: The invention provides 5,6,7,8-tetrahydroquinoline derivatives which are substituted at the 8-position by an amino group. The 8-amino compounds are intermediates for corresponding thiocarbamoyl derivatives which are anti-ulcer agents.

Abstract: The invention relates to novel 5,6,7,8-tetrahydroquinoline derivatives which have a group X situated at the 8-position said group X is CONHR.sup.3, or CO.sub.2 R.sup.5 wherein R.sup.3 is hydrogen lower alkyl and R.sup.5 is hydrogen, lower alkyl or a lower aralkyl radical.The compounds are intermediates for corresponding compounds where X is CSNHR.sup.3 and these are anti-ulcer agents.

Abstract: The invention provides 5,6,7,8-tetrahydroquinoline derivatives which are substituted at the 8-position by an amino group or the group NHCSNHR.sup.5 where R.sup.5 is hydrogen, alkyl of 1 - 3 carbon atoms which may be substituted by dialkylamino; lower alkanoyl or aroyl. The 8-amino cmpounds and those where R.sup.5 is lower alkanoyl or aroyl are intermediates. The other compounds are anti-ulcer agents.

Abstract: The invention relates to thioamides of formula I ##SPC1##and acid addition salts thereof wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, lower alkyl, and phenyl and R.sub.3 and R.sub. 4 are selected from the group consisting of hydrogen and lower alkoxy, with proviso that when R.sub.3 and R.sub.4 are both hydrogen at least one of R.sub.1 and R.sub.2 is other than hydrogen.