Patents by Inventor Roger Hartl
Roger Hartl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11903843Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.Type: GrantFiled: November 3, 2022Date of Patent: February 20, 2024Assignee: CORNELL UNIVERSITYInventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
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Publication number: 20240024537Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: February 2, 2023Publication date: January 25, 2024Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
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Patent number: 11812939Abstract: A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.Type: GrantFiled: May 15, 2018Date of Patent: November 14, 2023Assignee: CORNELL UNIVERSITYInventors: Lawrence J. Bonassar, Roger Hartl, Monika McCarter, Anny Cunha-Gavidia, Michael Messina, Gayathri Shibu, Si Chen
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Patent number: 11596713Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) comprising a nucleus pulposus structure comprising a first population of living cells and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and collagen.Type: GrantFiled: November 25, 2020Date of Patent: March 7, 2023Assignee: CORNELL UNIVERSITYInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20230056877Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.Type: ApplicationFiled: November 3, 2022Publication date: February 23, 2023Applicant: Cornell UniversityInventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
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Patent number: 11504245Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.Type: GrantFiled: June 29, 2018Date of Patent: November 22, 2022Assignee: CORNELL UNIVERSITYInventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
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Publication number: 20220039840Abstract: A novel endonasal method for occipitocervical fusion is provided. This new method provides a minimally invasive advance in the ability of surgeons to treat pathology of the craniocervical junction. The method uses an implant system comprising a body having a spacer section that engages with the occipital condyle and a plate section that engages with the C1 lateral mass. Fasteners fix the plate section with the occipital condyle the plate section with the C1 lateral mass.Type: ApplicationFiled: February 25, 2020Publication date: February 10, 2022Applicant: University of CincinnatiInventors: Bryan Matthew Krueger, Owen Andrew Yager, Justin Louis Gibson, Roger Hartl
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Publication number: 20210213168Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: November 25, 2020Publication date: July 15, 2021Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
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Publication number: 20210153854Abstract: A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.Type: ApplicationFiled: May 15, 2018Publication date: May 27, 2021Inventors: Lawrence J. BONASSAR, Roger HARTL, Monika MCCARTER, Anny CUNHA-GAVIDIA, Michael MESSINA, Gayathri SHIBU, Si CHEN
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Patent number: 10874764Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: June 16, 2019Date of Patent: December 29, 2020Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20200222200Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.Type: ApplicationFiled: June 29, 2018Publication date: July 16, 2020Applicant: Cornell UniversityInventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
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Publication number: 20190365949Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: June 16, 2019Publication date: December 5, 2019Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
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Patent number: 10363341Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: April 26, 2017Date of Patent: July 30, 2019Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20170290953Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: April 26, 2017Publication date: October 12, 2017Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Patent number: 9662420Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: May 12, 2015Date of Patent: May 30, 2017Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20160303284Abstract: The present invention is directed to a method of repairing an annulus. This method involves providing a collagen gel composition that includes collagen gel and a cross-linking agent. The collagen gel composition is injected into, around, or near an annulus repair site under conditions to repair the annulus. The cross-linking agent is included with or added to the collagen gel in an amount sufficient to cause cross-linking of the collagen gel and enable integration of the collagen gel composition with tissue near where said collagen gel composition is injected. Also disclosed is collagen gel composition.Type: ApplicationFiled: December 3, 2014Publication date: October 20, 2016Inventors: Brandon BORDE, Peter GRUNERT, Roger HARTL, Lawrence BONASSAR
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Publication number: 20150238657Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: May 12, 2015Publication date: August 27, 2015Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Patent number: 9044335Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: GrantFiled: May 5, 2010Date of Patent: June 2, 2015Assignee: Cornell UniversityInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
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Publication number: 20130079881Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.Type: ApplicationFiled: May 5, 2010Publication date: March 28, 2013Applicant: CORNELL UNIVERSITYInventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard