Patents by Inventor Roger Hartl

Roger Hartl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11903843
    Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.
    Type: Grant
    Filed: November 3, 2022
    Date of Patent: February 20, 2024
    Assignee: CORNELL UNIVERSITY
    Inventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
  • Publication number: 20240024537
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Application
    Filed: February 2, 2023
    Publication date: January 25, 2024
    Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
  • Patent number: 11812939
    Abstract: A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 14, 2023
    Assignee: CORNELL UNIVERSITY
    Inventors: Lawrence J. Bonassar, Roger Hartl, Monika McCarter, Anny Cunha-Gavidia, Michael Messina, Gayathri Shibu, Si Chen
  • Patent number: 11596713
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) comprising a nucleus pulposus structure comprising a first population of living cells and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and collagen.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: March 7, 2023
    Assignee: CORNELL UNIVERSITY
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Publication number: 20230056877
    Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.
    Type: Application
    Filed: November 3, 2022
    Publication date: February 23, 2023
    Applicant: Cornell University
    Inventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
  • Patent number: 11504245
    Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: November 22, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
  • Publication number: 20220039840
    Abstract: A novel endonasal method for occipitocervical fusion is provided. This new method provides a minimally invasive advance in the ability of surgeons to treat pathology of the craniocervical junction. The method uses an implant system comprising a body having a spacer section that engages with the occipital condyle and a plate section that engages with the C1 lateral mass. Fasteners fix the plate section with the occipital condyle the plate section with the C1 lateral mass.
    Type: Application
    Filed: February 25, 2020
    Publication date: February 10, 2022
    Applicant: University of Cincinnati
    Inventors: Bryan Matthew Krueger, Owen Andrew Yager, Justin Louis Gibson, Roger Hartl
  • Publication number: 20210213168
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Application
    Filed: November 25, 2020
    Publication date: July 15, 2021
    Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
  • Publication number: 20210153854
    Abstract: A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.
    Type: Application
    Filed: May 15, 2018
    Publication date: May 27, 2021
    Inventors: Lawrence J. BONASSAR, Roger HARTL, Monika MCCARTER, Anny CUNHA-GAVIDIA, Michael MESSINA, Gayathri SHIBU, Si CHEN
  • Patent number: 10874764
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Grant
    Filed: June 16, 2019
    Date of Patent: December 29, 2020
    Assignee: Cornell University
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Publication number: 20200222200
    Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.
    Type: Application
    Filed: June 29, 2018
    Publication date: July 16, 2020
    Applicant: Cornell University
    Inventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
  • Publication number: 20190365949
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Application
    Filed: June 16, 2019
    Publication date: December 5, 2019
    Inventors: Lawrence J. BONASSAR, Roger HARTL, Robert D. BOWLES, Harry H. GEBHARD
  • Patent number: 10363341
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: July 30, 2019
    Assignee: Cornell University
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Publication number: 20170290953
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Application
    Filed: April 26, 2017
    Publication date: October 12, 2017
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Patent number: 9662420
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 30, 2017
    Assignee: Cornell University
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Publication number: 20160303284
    Abstract: The present invention is directed to a method of repairing an annulus. This method involves providing a collagen gel composition that includes collagen gel and a cross-linking agent. The collagen gel composition is injected into, around, or near an annulus repair site under conditions to repair the annulus. The cross-linking agent is included with or added to the collagen gel in an amount sufficient to cause cross-linking of the collagen gel and enable integration of the collagen gel composition with tissue near where said collagen gel composition is injected. Also disclosed is collagen gel composition.
    Type: Application
    Filed: December 3, 2014
    Publication date: October 20, 2016
    Inventors: Brandon BORDE, Peter GRUNERT, Roger HARTL, Lawrence BONASSAR
  • Publication number: 20150238657
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Application
    Filed: May 12, 2015
    Publication date: August 27, 2015
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Patent number: 9044335
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: June 2, 2015
    Assignee: Cornell University
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Publication number: 20130079881
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Application
    Filed: May 5, 2010
    Publication date: March 28, 2013
    Applicant: CORNELL UNIVERSITY
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard