Patents by Inventor Roger L. Kaspar

Roger L. Kaspar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190337197
    Abstract: An active agent can be administered transdermally to a patient by using a transdermal patch that has microneedles that are compositionally homogenous with a base layer. The transdermal patch can contain an active agent that can be delivered to a skin surface of a subject when the patch is applied.
    Type: Application
    Filed: July 12, 2019
    Publication date: November 7, 2019
    Inventors: Roger L. KASPAR, Tycho Speaker
  • Patent number: 10377062
    Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: August 13, 2019
    Assignee: TRANSDERM, INC.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Patent number: 10172789
    Abstract: The present invention is drawn to formulations for the transdermal delivery of rapamycin or other related compounds. Specifically, in one embodiment a formulation for transdermally delivering rapamycin includes an mTOR inhibitor, such as rapamycin, water, a polymer having surfactant properties, a polymer having thickening properties, a solvent for solubilizing the mTOR inhibitor, a glycol, a C10-C20 fatty acid; and a base.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: January 8, 2019
    Assignee: PALVELLA THERAPEUTICS LLC
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20180345627
    Abstract: A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.
    Type: Application
    Filed: March 28, 2018
    Publication date: December 6, 2018
    Applicant: Transderm, Inc.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20180001070
    Abstract: The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.
    Type: Application
    Filed: May 8, 2017
    Publication date: January 4, 2018
    Applicant: Transderm, Inc.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20170209553
    Abstract: A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.
    Type: Application
    Filed: October 21, 2016
    Publication date: July 27, 2017
    Applicant: Transderm, Inc.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20160263362
    Abstract: The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.
    Type: Application
    Filed: June 30, 2015
    Publication date: September 15, 2016
    Applicant: TRANSDERM, INC.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20160184279
    Abstract: Methods of treating pain and/or itch in a targeted region of a subject and compositions and dosage forms therefor are described herein. Such methods can include topically administering a therapeutically effective amount of an mTOR pathway inhibitor to the subject.
    Type: Application
    Filed: December 10, 2015
    Publication date: June 30, 2016
    Applicant: Transderm, Inc.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20140315942
    Abstract: The present invention is drawn to formulations for the transdermal delivery of rapamycin or other related compounds. Specifically, in one embodiment a formulation for transdermally delivering rapamycin includes an mTOR inhibitor, such as rapamycin, water, a polymer having surfactant properties, a polymer having thickening properties, a solvent for solubilizing the mTOR inhibitor, a glycol, a C10-C20 fatty acid; and a base.
    Type: Application
    Filed: January 24, 2014
    Publication date: October 23, 2014
    Applicant: TRANSDERM, INC.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20140107177
    Abstract: The present invention relates to formulations and related methods for transdermal delivery of nucleic acids. Specifically, the invention relates to a formulation containing lipids and an alcohol and which is capable of providing effective transdermal delivery of nucleic acid. The formulation can be used effectively to deliver nucleic acids for gene therapy and the treatment of disease.
    Type: Application
    Filed: September 9, 2013
    Publication date: April 17, 2014
    Inventor: Roger L. Kaspar
  • Patent number: 8426380
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: April 23, 2013
    Assignee: Somagenics, Inc.
    Inventors: Roger L. Kaspar, Heini Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • Patent number: 8366677
    Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: February 5, 2013
    Assignee: Transderm, Inc.
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20120220033
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Application
    Filed: January 27, 2012
    Publication date: August 30, 2012
    Inventors: ROGER L. KASPAR, HEINI ILVES, ATTILA A. SEYHAN, ALEXANDER V. VLASSOV, BRIAN H. JOHNSTON
  • Publication number: 20120150023
    Abstract: The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.
    Type: Application
    Filed: June 9, 2011
    Publication date: June 14, 2012
    Inventors: Roger L. Kaspar, Tycho Speaker
  • Publication number: 20110269816
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Application
    Filed: March 2, 2011
    Publication date: November 3, 2011
    Inventors: Roger L. Kaspar, Heini Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • Patent number: 7902351
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: March 8, 2011
    Assignee: SomaGenics Inc.
    Inventors: Roger L. Kaspar, Heini Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • Patent number: 7723314
    Abstract: A method for treating pachyonychia congenita (PC) by identifying a genetic mutation contributing to PC, preparing a siRNA sequence that inhibits expression of the identified mutation, and administering the siRNA to a cell of a subject afflicted with PC. The siRNA treatment can include silencing of both the mutated and associated wildtype genes for a specific keratin. Specific mutations and inhibitory sequences are identified.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: May 25, 2010
    Assignee: Transderm, Inc.
    Inventors: Roger L. Kaspar, Robyn P. Hickerson, Frances J. D. Smith, W. H. Irwin McLean
  • Publication number: 20090170794
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) which are useful for inhibition of viralmediated gene expression. Small interfering RNAs as described herein may be used in methods of treatment of HCV infection. ShRNA and siRNA constructs that target the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Application
    Filed: September 12, 2005
    Publication date: July 2, 2009
    Applicant: SomaGenics Inc.
    Inventors: Roger L. Kaspar, Heine Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • Publication number: 20090043279
    Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
    Type: Application
    Filed: August 6, 2008
    Publication date: February 12, 2009
    Inventors: Roger L. Kaspar, Tycho Speaker