Abstract: A metadata driven user interface system and method are provided. In an exemplary embodiment, a software-based customer relationship management system and method may include the metadata driven user interface system.

Abstract: The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.

Abstract: Disclosed herein are immunogenic compositions for producing immediate and sustained immunity to infectious viral and bacteriological pathogens. A univalent immunogenic composition is disclosed comprising an isolated antigen and a polynucleotide formulated into a nanoparticle or liposome. Furthermore, multivalent immunogenic compositions are disclosed comprising multiple univalent immunogenic compositions. Also disclosed, are methods of inducing protective or therapeutic immune responses in individuals comprising administering one or more univalent immunogenic compositions.

Abstract: One aspect of the present disclosure relates to a backplane initiator for testing enclosure management controller. The backplane initiator includes: an initiator board and an initiator control application. The initiator board includes initiator controller, at least one SGPIO interface, at least one SMBus interface, and a first communication interface. The initiator controller is configured to transmit control commands and data according to enclosure management protocol through the SGPIO interface and the SMBus interface to an EMC.

Abstract: Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.

Abstract: A fault-tolerant computer system architecture includes two types of operating domains: a conventional first domain (DID) that processes data and instructions, and a novel second domain which includes mentor processors for mentoring the DID according to “meta information” which includes but is not limited to data, algorithms and protective rule sets. The term “mentoring” (as defined herein below) refers to, among other things, applying and using meta information to enforce rule sets and/or dynamically erecting abstractions and virtualizations by which resources in the DID are shuffled around for, inter alia, efficiency and fault correction. Meta Mentor processors create systems and sub-systems by means of fault tolerant mentor switches that route signals to and from hardware and software entities. The systems and sub-systems created are distinct sub-architectures and unique configurations that may be operated as separately or concurrently as defined by the executing processes.

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

Abstract: This invention uses “targeted apheresis” to treat pregnant women who are at risk of developing eclampsia. “Targeted Apheresis” is a process whereby certain growth factor receptors (sFlt-1) circulating in the blood of a pregnant woman at risk of developing pre-eclampsia are selectively removed by passing the blood through a cartridge containing immobilized anti-sFlt-1 aptamers. The circulating sFlt-1 is bound out by the immobilized anti-sFlt-1 aptamers and the cleaned blood is returned to the patient. Removal of circulating sFlt-1 will diminish the risk of developing eclampsia during pregnancy.

Abstract: A software-based customer relationship management system and method.

Abstract: A support for electrical cables having a nonconductive telescoping pole. A frictional locking collar couples sections of the telescoping pole to one another. The bottom end of the pole fits into a round conical base formed of recycled tires. The top end of the pole is affixed to a nonconductive head that is shaped to cradle electrical cables.

Abstract: The present invention is concerned with a basket processing apparatus that includes a basket storage portion in a form of a horizontal load rail (2). A plurality of slide storage baskets (4) can be located in series on the rail (2). Each basket is “side loading” and the side loading aperture of each basket can be selectively covered by a slide retaining bar (6). When the baskets (4) are placed on the load rail (2) (e.g. by hooking or clipping the baskets onto the rail), the basket can be moved along the horizontal rail by a basket moving means. The arrangement of the rail and the basket moving means is such that the baskets can be pushed together and move as a “train”. Baskets moved to the pick-up end (12) of the rail can then be removed from the rail and processed. A vertical lift mechanism can be used to remove the basket and transport it to a processing device, for example a coverslipper.

Abstract: One aspect of the present disclosure relates to a backplane initiator for testing enclosure management controller. The backplane initiator includes: an initiator board and an initiator control application. The initiator board includes initiator controller, at least one SGPIO interface, at least one SMBus interface, and a first communication interface. The initiator controller is configured to transmit control commands and data according to enclosure management protocol through the SGPIO interface and the SMBus interface to an EMC.

Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

Abstract: The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.

Abstract: A vehicle display system and methods of controlling the same. In certain embodiments, an image processing module receives video signals from a video camera and generates first video data in a first format. A system management mode (SMM) program is stored in a memory. When executed at a processor, the SMM program reads the first video data from a first area of the memory, converts the first video data to second video data in a second format, and writes the second video data to a second area of the memory. A PCI express switch forwards the first video data in the first format to a memory controller for storing in the first area of the memory, and forwards the second video data in the second format from the second area of the memory to the graphic controller.

Abstract: The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

Abstract: A support for electrical cables having a nonconductive telescoping pole. A frictional locking collar couples sections of the telescoping pole to one another. The bottom end of the pole fits into a round conical base formed of recycled tires. The top end of the pole is affixed to a nonconductive head that is shaped to cradle electrical cables.

Abstract: Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.

Abstract: Certain aspects of the present disclosure are directed to a video processing module, including: a video capture module configured to capture a screen display; a compression module configured to compress the screen display to construct compressed data representing the screen display; and a memory module configured to store the compressed data. Certain aspects are directed to a computer-implementable method, including: reading compressed video data having a plurality of data units and representing a screen display out of a data storage, the data units including a line tag, an encoding tag, and a pixel value data unit; detecting a line tag from the compressed video data and extracting a line number from the line tag; receiving an expected line number from a counter; comparing the line number with the expected line number and determining a comparison result; and determining whether a fault exists based on the result.