Patents by Inventor Rokuro Masuma
Rokuro Masuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170215422Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.Type: ApplicationFiled: April 17, 2017Publication date: August 3, 2017Inventors: Masaaki MITOMI, Masayo SAKAI, Ryo HORIKOSHI, Yasumichi ONOZAKI, Satoshi NAKAMURA, Satoshi OMURA, Toshiaki SUNAZUKA, Tomoyasu HIROSE, Kazuro SHIOMI, Rokuro MASUMA
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Publication number: 20150166608Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.Type: ApplicationFiled: June 13, 2013Publication date: June 18, 2015Inventors: Masaaki Mitomi, Masayo Sakai, Ryo Horikoshi, Yasumichi Onozaki, Satoshi Nakamura, Satoshi Omura, Toshiaki Sunazuka, Tomoyasu Hirose, Kazuro Shiomi, Rokuro Masuma
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Patent number: 8378125Abstract: This invention relates to substance FKI-3864 represented by the following formula [I] having an inhibitory activity on the synthesis of triacylglycerols and a method for preparing the same. The substance FKI-3864 can be prepared by a method comprising culturing a microorganism which belongs to the genus Penicillium and is capable of producing the substance FKI-3864, and particularly Penicillium pinophilum FKI-3864 (FERM BP-11093) so as to accumulate the substance FKI-3864 in the culture and collecting the substance FKI-3864 from the culture. The substance has an inhibitory activity on the synthesis of intracellular triacylglycerols and is useful for prevention or treatment of obesity.Type: GrantFiled: February 12, 2009Date of Patent: February 19, 2013Assignee: School Juridical Person Kitasato InstituteInventors: Hiroshi Tomoda, Ryuji Uchida, Rokuro Masuma, Satoshi Omura
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Patent number: 8269051Abstract: The present invention includes wickerol and a method for producing the wickerol. In the method for producing the wickerol, Trichoderma atroviride strain FKI-3737 (FERM ABP-11099 corresponding to FERM BP-11099) belonging to filamentous fungi is cultured in a medium, and the wickerol is accumulated in a culture, and then the produced wickerol is isolated and purified from the culture. A substance having inhibitory activity against influenza virus replication and containing the wickerol as an active ingredient, and an anti-influenza drug containing the wickerol as an active ingredient are obtained.Type: GrantFiled: March 12, 2009Date of Patent: September 18, 2012Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Hideaki Ui, Takayuki Nagai, Haruki Yamada
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Publication number: 20110105769Abstract: This invention relates to substance FKI-3864 represented by the following formula [I] having an inhibitory activity on the synthesis of triacylglycerols and a method for preparing the same. The substance FKI-3864 can be prepared by a method comprising culturing a microorganism which belongs to the genus Penicillium and is capable of producing the substance FKI-3864, and particularly Penicillium pinophilum FKI-3864 (FERM BP-11093) so as to accumulate the substance FKI-3864 in the culture and collecting the substance FKI-3864 from the culture. The substance has an inhibitory activity on the synthesis of intracellular triacylglycerols and is useful for prevention or treatment of obesity.Type: ApplicationFiled: February 12, 2009Publication date: May 5, 2011Applicant: SCHOOL JURIDICAL PERSON KITASATO INSTITUTEInventors: Hiroshi Tomoda, Ryuji Uchida, Rokuro Masuma, Satoshi Omura
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Publication number: 20110021848Abstract: The present invention includes wickerol and a method for producing the wickerol. In the method for producing the wickerol, Trichoderma atroviride strain FKI-3737 (FERM ABP-11099 corresponding to FERM BP-11099) belonging to filamentous fungi is cultured in a medium, and the wickerol is accumulated in a culture, and then the produced wickerol is isolated and purified from the culture. A substance having inhibitory activity against influenza virus replication and containing the wickerol as an active ingredient, and an anti-influenza drug containing the wickerol as an active ingredient are obtained.Type: ApplicationFiled: March 12, 2009Publication date: January 27, 2011Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Hideaki Ui, Takayuki Nagai, Haruki Yamada
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Publication number: 20100291622Abstract: The present invention provides compounds which exhibit an inhibitory effect on undecaprenyl diphosphate synthase of microbes and thereby they are expected to be used clinically as pharmaceutical agents for infectious diseases caused by bacteria. The process comprises culturing a microbe belonging to Penicillium and having ability of producing an FKI-3368 substance in or on a nutrient medium to accumulate the FKI-3368 substance in the nutrient medium and collecting the FKI-3368 substance from the culture.Type: ApplicationFiled: September 12, 2008Publication date: November 18, 2010Applicant: SCHOOL JURIDICAL PERSON KITASATO INSTITUTEInventors: Hiroshi Tomoda, Junji Inokoshi, Rokuro Masuma, Satoshi Omura
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Patent number: 7794991Abstract: The present invention relates to novel stemphones having enhancing effect of ?-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE BP-83, accumulating the stemphones in the cultured mass, and isolating the stemphones from the cultured mass. Since the obtained stemphones have an action enhancing activity of ?-lactam antibiotic used as an antibacterial agent by combining with ?-lactam antibiotic, the stemphones are expected to be useful as the therapeutic agent for MRSA infection and infectious diseases caused by multi-drug resistant microorganisms including ?-lactam antibiotic resistance.Type: GrantFiled: October 3, 2005Date of Patent: September 14, 2010Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Patent number: 7541336Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance from the cultured mass. The thus obtained FKI-1033 substance has ryanodine binding inhibition activity, insecticidal activity and anthelmintic activity, and is expected as useful drugs as agrochemicals, veterinary drugs and medicaments in effectiveness and toxicity.Type: GrantFiled: November 12, 2002Date of Patent: June 2, 2009Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Patent number: 7514455Abstract: An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or its tautomer 2-pyridone derivative represented by the general formula [II] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or salt thereof as an active ingredient. The compound inhibits the complex II strongly with nM order activity. Consequently, 2-pyridinol derivative or its tautomer, 2-pyridone derivative, are useful as the complex II inhibitor.Type: GrantFiled: June 10, 2002Date of Patent: April 7, 2009Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Hiroshi Tomoda, Rokuro Masuma, Kiyoshi Kita
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Publication number: 20080160587Abstract: The present invention relates to novel stemphones having enhancing effect of ?-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE BP-83, accumulating the stemphones in the cultured mass, and isolating the stemphones from the cultured mass. Since the obtained stemphones have an action enhancing activity of ?-lactam antibiotic used as an antibacterial agent by combining with ?-lactam antibiotic, the stemphones are expected to be useful as the therapeutic agent for MRSA infection and infectious diseases caused by multi-drug resistant microorganisms including ?-lactam antibiotic resistance.Type: ApplicationFiled: October 3, 2005Publication date: July 3, 2008Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Publication number: 20070032545Abstract: A microorganism belonging to filamentous fungi, capable of producing antibiotic FKI-1778A and/or FKI-1778B and/or FKI-1778C and/or FKI-1778D is cultured in a culture medium to thereby accumulate the antibiotic FKI-1778A and/or FKI-1778B and/or FKI-1778C and/or FKI-1778D in the culture mixture. The antibiotic FKI-1778A and/or FKI-1778B and/or FKI-1778C and/or FKI-1778D is collected from the culture mixture. The thus obtained substance is promising as drugs, veterinary medicines or agrichemicals having a growth inhibiting activity to microorganisms, nematodes and arthropods or as drugs exhibiting a growth inhibiting activity to carcinoma cells.Type: ApplicationFiled: March 24, 2004Publication date: February 8, 2007Inventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Patent number: 7132447Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula: in a medium, accumulating FKI-1083 substance in the cultured medium, and isolating FKI-1083 substance from the cultured mass. The thus obtained FKI-1083 substance has growth inhibitory activities against microorganisms, nematodes and arthropods, and is useful as anthelmintic and insecticide.Type: GrantFiled: December 11, 2001Date of Patent: November 7, 2006Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Publication number: 20060111280Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance from the cultured mass. The thus obtained FKI-1033 substance has ryanodine binding inhibition activity, insecticidal activity and anthelmintic activity, and is expected as useful drugs as agrochemicals, veterinary drugs and medicaments in effectiveness and toxicity.Type: ApplicationFiled: November 12, 2002Publication date: May 25, 2006Inventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Publication number: 20050032883Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula: in a medium, accumulating FKI-1083 substance in the cultured medium, and isolating FKI-1083 substance from the cultured mass. The thus obtained FKI-1083 substance has growth inhibitory activities against microorganisms, nematodes and arthropods, and is useful as anthelmintic and insecticide.Type: ApplicationFiled: December 11, 2001Publication date: February 10, 2005Inventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Publication number: 20040266835Abstract: An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I] 1Type: ApplicationFiled: August 17, 2004Publication date: December 30, 2004Inventors: Satoshi Omura, Kazuro Shiomi, Hiroshi Tomoda, Rokuro Masuma, Kiyoshi Kita
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Publication number: 20040265979Abstract: The present invention relates to a novel FKA-25 substance, which inhibits formation of the foam macrophage originated from mouse, having inhibitory action against formation of the foam macrophage and a process for production thereof. The process includes culturing Pseudobotrytis sp. FKA-25 belonging to genus Pseudobotrytis sp. and having ability to produce FKA-25 substance in a medium, accumulating FKA-25 substance in the cultured medium, and collecting FKA-25 substance from the cultured mass. The obtained FKA-25 substance specifically inhibits the formation of the foam macrophage originated from mouse and is expected to be useful for prevention and treatment of arteriosclerosis and causative diseases therefrom.Type: ApplicationFiled: August 25, 2004Publication date: December 30, 2004Inventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Patent number: 6790968Abstract: A microorganism having ability to produce FKI-0076 substance represented by the following formula [I] is cultured in a medium allowing for the accumulation of FKI-0076 substance in the culture liquid. The FKI-0076 substance from can then be isolated the cultured mass. Since the substance has the ability to enhance azole antifungal agents, it provides an action against various fungal infections such as deep-seated mycosis and other fungal infections in low concentration and within a short term. Consequently, the FKI-0076 is useful for reducing the frequency of appearance of resistant microorganisms. Further, usefulness for overcoming resistance is expected.Type: GrantFiled: October 24, 2002Date of Patent: September 14, 2004Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma, Masayoshi Arai
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Patent number: 6608185Abstract: A microorganism which belongs to the genus Gliocladium and has the ability to produce stereoisomers KF-1040T4A and KF-1040T4B which are compounds represented by the following formula [I], and stereoisomers KF-1040T5A and KF-1040T5B which are compounds represented by the following formula [II], is cultivated in a culture medium to accumulate KF-1040T4A and/or KF-1040T4B and/or KF-1040T5A and/or KF-1040T5B in the culture medium, and the substance KF-1040T4A and/or KF-1040T4B and/or KF-1040T5A and/or KF-1040T5B are harvested from the culture medium. The obtained substances are useful for the prevention and treatment of the diseases relating to arteriosclerosis, obesity, thrombosis, inflammations and immunofunctional disorders.Type: GrantFiled: January 14, 2002Date of Patent: August 19, 2003Assignee: Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Patent number: 6486197Abstract: The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis. The present invention comprising the steps of culturing the microorganism belonging to fungi having producing activity of FT-0554 substance represented by the following formula [I] subjected ho accumulation of FT-0554 substance in the cultured medium, and isolating FT-0554 substance from the said cultured mass. The medicament useful for treatment of parasitic infection, specifically helminthiasis can be obtained.Type: GrantFiled: August 3, 2000Date of Patent: November 26, 2002Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Yuzuru Iwai