Patents by Inventor Roland K. STRONG

Roland K. STRONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHELATING PLATFORM FOR DELIVERY OF RADIONUCLIDES
    Publication number: 20220160904
    Abstract: Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.
    Type: Application
    Filed: December 10, 2021
    Publication date: May 26, 2022
    Applicants: Fred Hutchinson Cancer Research Center, The Regents of the University of California
    Inventors: Roland K. Strong, Peter Rupert, Rebecca J. Abergel, Ilya Captain, Gauthier JP Deblonde
  • Chelating platform for delivery of radionuclides
    Patent number: 11235076
    Abstract: Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: February 1, 2022
    Assignees: Fred Hutchinson Cancer Research Center, The Regents of the Universitv of California
    Inventors: Roland K. Strong, Peter Rupert, Rebecca J. Abergel, Ilya Captain, Gauthier J P Deblonde
  • Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof
    Patent number: 10987417
    Abstract: Engineered and multimerized human immunodeficiency virus (HIV) envelope glycoproteins are described. The envelope glycoproteins can be multimerized using a heptamerization domain such as a C4b binding protein multimerization domain or a ferritin fusion. The engineered and multimerized envelope glycoproteins can derived from glycoprotein 120 (gp120) and can used as an HIV vaccine.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: April 27, 2021
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Roland K. Strong, Colin Correnti, Leonidas Stamatatos, Andrew McGuire
  • CHELATING MOLECULES
    Publication number: 20210009510
    Abstract: Provided herein are a variety of metal chelators as well as methods of use thereof.
    Type: Application
    Filed: August 28, 2017
    Publication date: January 14, 2021
    Inventors: Rebecca J. ABERGEL, Julian REES, Roland K. STRONG, llya CAPTAIN
  • NKG2D decoys
    Patent number: 10815290
    Abstract: Single chain, multimerized, and/or glycosylated NKG2D decoys are described. The NKG2D decoys have high affinity and avidity for surface bound and soluble NKG2D ligands and can be used to (i) identify NKG2D ligands; (ii) treat cancer, graft vs. host disease (GVHD), and inflammatory conditions; and (iii) potentiate an immune response against a vaccine as well as many other potential uses.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: October 27, 2020
    Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Mesfin Gewe, Roland K. Strong, Martin Prlic, Peter Rupert, Thomas Spies, Veronika Spies
  • ENGINEERED AND MULTIMERIZED HUMAN IMMUNODEFICIENCY VIRUS ENVELOPE GLYCOPROTEINS AND USES THEREOF
    Publication number: 20190321461
    Abstract: Engineered and multimerized human immunodeficiency virus (HIV) envelope glycoproteins are described. The envelope glycoproteins can be multimerized using a heptamerization domain such as a C4b binding protein multimerization domain or a ferritin fusion. The engineered and multimerized envelope glycoproteins can derived from glycoprotein 120 (gp120) and can used as an HIV vaccine.
    Type: Application
    Filed: June 3, 2019
    Publication date: October 24, 2019
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Roland K. Strong, Colin Correnti, Leonidas Stamatatos, Andrew McGuire
  • SEPARATION OF METAL IONS BY LIQUID-LIQUID EXTRACTION
    Publication number: 20190287691
    Abstract: Provided herein are separation processes for metal ions present in aqueous solutions based on methods involving liquid-liquid extraction. The separation process involves a chelator that can selectively bind to at least one of the metals at a relatively low pH. This can be used, for example, for recovery and purification of actinides from lanthanides, separation of metal ions based on their valence, and separation of metal ions based on the pH of the extraction conditions.
    Type: Application
    Filed: March 26, 2019
    Publication date: September 19, 2019
    Inventors: Rebecca J. ABERGEL, Roland K. STRONG, Gauthier J.P. DEBLONDE, Abel RICANO
  • Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof
    Patent number: 10342863
    Abstract: Multimerized human immunodeficiency virus (HIV) envelope glycoproteins are described. The envelope glycoproteins are multimerized Engineered and multimerized human immunodeficiency virus (HIV) envelope glycoproteins are described. The envelope glycoproteins can be multimerized using a heptamerization domain such as a C4b binding protein multimerization domain or a ferritin fusion. The engineered and multimerized envelope glycoproteins can derived from glycoprotein 120 (gp 120) and can used as an HIV vaccine.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: July 9, 2019
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Roland K. Strong, Colin Correnti, Leonidas Stamatatos, Andrew McGuire
  • CHELATING PLATFORM FOR DELIVERY OF RADIONUCLIDES
    Publication number: 20190184041
    Abstract: Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 20, 2019
    Applicants: Fred Hutchinson Cancer Research Center, The Regents of the University of California
    Inventors: Roland K. Strong, Peter Rupert, Rebecca J. Abergel, Ilya Captain, Gauthier JP Deblonde
  • LIPOCALIN FUSION PARTNERS
    Publication number: 20190101528
    Abstract: Methods and systems for producing fusion proteins and peptides are disclosed. Fusion proteins and peptides created using the methods are also provided. Also provided are methods of using the fusion proteins and peptides produced according to the present disclosure.
    Type: Application
    Filed: December 11, 2018
    Publication date: April 4, 2019
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: James Olson, Christopher Mehlin, Colin Correnti, Roland K. Strong
  • NKG2D DECOYS
    Publication number: 20180371051
    Abstract: Single chain, multimerized, and/or glycosylated NKG2D decoys are described. The NKG2D decoys have high affinity and avidity for surface bound and soluble NKG2D ligands and can be used to (i) identify NKG2D ligands; (ii) treat cancer, graft vs. host disease (GVHD), and inflammatory conditions; and (iii) potentiate an immune response against a vaccine as well as many other potential uses.
    Type: Application
    Filed: November 10, 2016
    Publication date: December 27, 2018
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Roland K. Strong, Mesfin Gewe, Martin Prlic, Peter Rupert, Thomas Spies, Veronika Spies
  • ENGINEERED AND MULTIMERIZED HUMAN IMMUNODEFICIENCY VIRUS ENVELOPE GLYCOPROTEINS AND USES THEREOF
    Publication number: 20180117140
    Abstract: Multimerized human immunodeficiency virus (HIV) envelope glycoproteins are described. The envelope glycoproteins are multimerized Engineered and multimerized human immunodeficiency virus (HIV) envelope glycoproteins are described. The envelope glycoproteins can be multimerized using a heptamerization domain such as a C4b binding protein multimerization domain or a ferritin fusion. The engineered and multimerized envelope glycoproteins can derived from glycoprotein 120 (gp120) and can used as an HIV vaccine.
    Type: Application
    Filed: March 24, 2016
    Publication date: May 3, 2018
    Inventors: Roland K. STRONG, Colin CORRENTI, Leonidas STAMATATOS, Andrew McGUIRE