Patents by Inventor Rolf-Dieter Gabel

Rolf-Dieter Gabel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8124010
    Abstract: A reusable container for the sterile transfer of pharmaceutical recipients, in particular of syringe bodies. The container comprises an outer case and a sterilizable interior, wherein the interior is microbially isolated from the environment of the container. The interior has at least one holder for accommodating at least one nest for storing a plurality of pharmaceutical recipients. The nest can be removably accommodated in the holder. The container further has at least one container door for removing or introducing the nest into the interior and at least one lock for coupling the container to a sterile space. The lock is configured in such a way that, after coupling to the sterile space, it is possible to open the container door without substantially suspending sterility.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: February 28, 2012
    Assignee: F. Hoffman-La Roche AG
    Inventors: Rolf-Dieter Gabel, Martin Knierim
  • Publication number: 20110024419
    Abstract: A reusable container for the sterile transfer of pharmaceutical recipients, in particular of syringe bodies. The container comprises an outer case and a sterilizable interior, wherein the interior is microbially isolated from the environment of the container. The interior has at least one holder for accommodating at least one nest for storing a plurality of pharmaceutical recipients. The nest can be removably accommodated in the holder. The container further has at least one container door for removing or introducing the nest into the interior and at least one lock for coupling the container to a sterile space. The lock is configured in such a way that, after coupling to the sterile space, it is possible to open the container door without substantially suspending sterility.
    Type: Application
    Filed: August 12, 2010
    Publication date: February 3, 2011
    Inventors: Rolf-Dieter Gabel, Martin Knierim
  • Publication number: 20060148878
    Abstract: The present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them.
    Type: Application
    Filed: January 5, 2006
    Publication date: July 6, 2006
    Inventors: Andre Bubendorf, Rolf-Dieter Gabel, Michael Hennig, Siegfried Krimmer, Guenter Neugebauer, Walter Preis, Alexander Wirl
  • Publication number: 20050271721
    Abstract: The present invention is concerned with pharmaceutically acceptable compositions comprising carvedilol or a pharmaceutically acceptable salt thereof distributed as a molecular dispersion in a concentration above 5% (wt./wt.), as well as pharmaceutical administration forms comprising such compositions and their use for the treatment and/or prophylaxis of illnesses such as hypertension, cardiac insufficiency or angina pectoris.
    Type: Application
    Filed: August 16, 2005
    Publication date: December 8, 2005
    Inventors: Rolf-Dieter Gabel, Guenter Neugebauer, Walter Preis, Alexander Wirl
  • Publication number: 20050089573
    Abstract: The invention is directed to well-tolerated pharmaceutical compositions for oral application, containing ibandronate or a physiologically tolerable salt thereof as active substance, the administration form consisting of an active substance-containing inner portion enclosed in such fashion by a coat free of active substance that rapid release of the active substance takes place.
    Type: Application
    Filed: September 12, 2003
    Publication date: April 28, 2005
    Applicants: F. HOFFMANN-LA ROCHE, ROCHE DIAGNOSTICS GmbH
    Inventors: Joern Moeckel, Rolf-Dieter Gabel, Heinrich Woog
  • Patent number: 6852337
    Abstract: The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from the active substance and one or more water-soluble adjuvants and then the resulting aqueous suspension is processed, with removal of the water, by methods conventional per se, to form solid pharmaceutical preparations. The invention also relates to fast-dissolving pharmaceutical preparations of active substances having a dissolution rate of at least 70% after 30 minutes, prepared in accordance with the process of the invention.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: February 8, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Rolf-Dieter Gabel, Walter Preis, Alexander Wirl
  • Publication number: 20040204474
    Abstract: The present invention is concerned with pharmaceutically acceptable solutions of carvedilol or pharmaceutically acceptable salts thereof containing adjuvants with lipophilic character, with the carvedilol content lying above 5% (wt./wt., based on the solution) and the carvedilol being distributed in the solution as a molecular dispersion, as well as pharmaceutical administration forms containing such solutions and their use for the treatment and/or prophylaxis of illnesses, such as hypertension, cardiac insufficiency or angina pectoris.
    Type: Application
    Filed: April 29, 2004
    Publication date: October 14, 2004
    Inventors: Silke Decker, Rolf-Dieter Gabel, Juergen Lapotnikoff, Alexander Wirl, Ingfried Zimmermann
  • Publication number: 20040198812
    Abstract: The present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 7, 2004
    Inventors: Andre Gerard Bubendorf, Rolf-Dieter Gabel, Michael Hennig, Siegfried Krimmer, Guenter Neugebauer, Walter Preis, Alexander Wirl
  • Patent number: 6689755
    Abstract: The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture and drying the resulting mixture into a dry, amorphous product by means of convection drying. The invention also relates to the amorphous, microscopically homogeneous products which are obtained by this process, are in the form of powders and have a uniform geometric, in particular spherical, shape. The invention furthermore relates to the use of substance mixtures for stabilizing biologically active material, in particular proteins by means of spray drying.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: February 10, 2004
    Assignee: Boehringer Mannheim GmbH
    Inventors: Rolf-Dieter Gabel, Markus Mattern, Gerhard Winter, Alexander Wirl, Heinrich Woog
  • Patent number: 6627221
    Abstract: The invention relates to a solid pharmaceutical form of administration containing a diphosphonic acid or a physiologically compatible salt thereof as the active substance, wherein the active substance is present in granulate form, optionally together with pharmaceutical adjuvants in the inner phase, and the outer phase contains a lubricant in the form of less than 5% by weight of stearic acid relative to the total weight of the form of administration.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: September 30, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rolf-Dieter Gabel, Walter Preis, Heinrich Woog
  • Publication number: 20030118643
    Abstract: The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from active substance and one or more water-soluble adjuvants and then the resulting aqueous suspension is processed, with removal of the water, by methods conventional per se, to form solid pharmaceutical preparations. The invention also relates to fast-dissolving pharmaceutical preparations of active substances having a dissolution rate of at least 70% after 30 minutes, prepared in accordance with the process of the invention.
    Type: Application
    Filed: October 22, 2002
    Publication date: June 26, 2003
    Inventors: Rolf-Dieter Gabel, Walter Preis, Alexander Wirl
  • Publication number: 20030119893
    Abstract: The present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them.
    Type: Application
    Filed: September 26, 2002
    Publication date: June 26, 2003
    Inventors: Andre Gerard Bubendorf, Rolf-Dieter Gabel, Michael Hennig, Siegfried Krimmer, Guenter Neugebauer, Walter Preis, Alexander Wirl
  • Patent number: 6521262
    Abstract: The present invention concerns solid instant-release forms of administration (IR form of administration) comprising therapeutic active substances or active substance concentrates in particular lipid conjugates of nucleosides which have gel-forming properties in aqueous media as well as processes for their production.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: February 18, 2003
    Assignee: Heidelberg Pharma Holding GmbH
    Inventors: Rolf-Dieter Gabel, Alexander Wirl, Heinrich Woog
  • Publication number: 20030004206
    Abstract: The present invention is concerned with pharmaceutically acceptable solutions of carvedilol or pharmaceutically acceptable salts thereof containing adjuvants with lipophilic character, with the carvedilol content lying above 5% (wt./wt., based on the solution) and the carvedilol being distributed in the solution as a molecular dispersion, as well as pharmaceutical administration forms containing such solutions and their use for the treatment and/or prophylaxis of illnesses, such as hypertension, cardiac insufficiency or angina pectoris.
    Type: Application
    Filed: August 14, 2002
    Publication date: January 2, 2003
    Inventors: Silke Decker, Rolf-Dieter Gabel, Juergen Lapotnikoff, Alexander Wirl, Ingfried Zimmermann
  • Publication number: 20030004205
    Abstract: The present invention is concerned with pharmaceutically acceptable compositions comprising carvedilol or a pharmaceutically acceptable salt thereof distributed as a molecular dispersion in a concentration above 5% (wt./wt.), as well as pharmaceutical administration forms comprising such compositions and their use for the treatment and/or prophylaxis of illnesses such as hypertension, cardiac insufficiency or angina pectoris.
    Type: Application
    Filed: August 8, 2002
    Publication date: January 2, 2003
    Inventors: Rolf-Dieter Gabel, Guenter Neugebauer, Walter Preis, Alexander Wirl
  • Publication number: 20020122817
    Abstract: The present invention concerns solid instant-release forms of administration (IR form of administration) comprising therapeutic active substances or active substance concentrates in particular lipid conjugates of nucleosides which have gel-forming properties in aqueous media as well as processes for their production.
    Type: Application
    Filed: July 27, 1998
    Publication date: September 5, 2002
    Inventors: ROLF-DIETER GABEL, ALEXANDER WIRL, HEINRICH WOOG
  • Patent number: 6431399
    Abstract: A pill dispenser allows for alternating removal of two or more solid forms of pharmaceutical medications, such as tablets, film tablets, coated tablets, or capsules. The pill dispenser has a housing, a baseplate, at least two storage containers for receiving and storing a solid form of medication, and a dosing slide. The baseplate is attached to the bottom end of the housing and has at least one ejecting opening. The storage containers are adapted for receiving and storing solid forms of medications. Each storage container has a bottom opening. A dosing slide is movably mounted between the storage containers and the baseplate and has receiving openings arranged in the dosing slide so that each of the receiving openings can be positioned under a bottom opening of a storage container and above an ejecting opening.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: August 13, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Rolf-Dieter Gabel, Jörn Möckel
  • Patent number: 6419955
    Abstract: The present invention relates to a process for the preparation of bisphonate-containing pharmaceutical compositions for oral administration wherein the active substance is wet-granulated in a fluidized-bed granulator and the wet granulate is dried in the fluidised bed granulator. The dried granulate is further processed to produce desired dosage forms.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: July 16, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rolf-Dieter Gabel, Jörn Möckel, Heinrich Woog
  • Patent number: 6379706
    Abstract: The invention concerns pharmaceutical forms of administration that are in the form of pellets which contain a retarding agent in which the release rate of the active substance is not delayed or is substantially identical compared to corresponding pellets that contain no retarding agent. The release rate of these rapidly disintegrating pellets is at least about 90% within a time period of 30 minutes. In addition the present invention also concerns processes for the production these pellets.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: April 30, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Michaela Opitz, Hendrik Von Burën, Rolf-Dieter Gabel, Geoffrey Lee
  • Publication number: 20020006441
    Abstract: The invention relates to a solid pharmaceutical form of administration containing a diphosphonic acid or a physiologically compatible salt thereof as the active substance, wherein the active substance is present in granulate form, optionally together with pharmaceutical adjuvants in the inner phase, and the outer phase contains a lubricant in the form of less than 5% by weight of stearic acid relative to the total weight of the form of administration.
    Type: Application
    Filed: July 20, 2001
    Publication date: January 17, 2002
    Inventors: Rolf-Dieter Gabel, Walter Preis, Heinrich Woog