Abstract: A method and composition for treatment of a microbial infection of a patient involves introduction into the gut of a patient an antimicrobial amount of an antimicrobial medicament which is cell wall constituent-inactivating, endotoxin non-releasing, exotoxin-inactivating or a combination thereof.

Abstract: The invention provides products containing tumour necrosis factor (TNF), and taurolidine and/or taurultam as a combined preparation for simultaneous, separate or sequential use for treatment of patients suffering from medical conditions mediated by TNF.

Abstract: The invention provides a purified particulate bone mineral product for use in medicine, the particles of said mineral being substantially free from all endogenous organic material and having at least at the surface thereof resorbable, physiologically compatible, natural or synthetic macromolecular material. In particular the invention provides a bone mineral impregnated with a gel-forming protein or polysaccharide such as gelatin to provide a surprising increase in strength and a product comprising bone mineral in a matrix of collagen-fibres and a gel-forming protein. Such products are intended as remodeling implants or prosthetic bone replacement.

Abstract: An aqueous solution containing a bacterially effective concentration of taurolidine and/or taurultam together with a parenterally acceptable polyol. The aqueous solution is particularly suitable for parenteral administration.

Abstract: The invention provides a pharmaceutical composition for filling into bone cavities comprising an agueous paste formed from powdered calcium phosphate and an antibacterial substance, if necessary together with one or more binders. The antibacterial substance is preferably taurolidine and the calcium phosphate is preferably .beta.-tricalcium phosphate.

Abstract: Compounds of formula (I) ##STR1## [wherein R.sup.1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula II ##STR2## in which R.sup.1 is as defined above] and pharmaceutical compositions thereof may be administered to humans or warm-blooded animals to combat toxic proteins or peptides, e.g. venoms, fungal toxins and bacterial exotoxins, in the bloodstream.

Abstract: Compounds of formula (I) ##STR1## [wherein R.sup.1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula (II) ##STR2## in which R.sup.1 is as defined above] and pharmaceutical compositions thereof may be administered prophylactically to humans or warm-blooded animals to combat the occurrence of osteitis or osteomyelitis, especially in patients suffering from bone injuries of traumatic origin.

Abstract: A composition comprising a resorbable aqueous gel having dissolved or dispersed therein one or more water-soluble medicaments is of use in the treatment of wounds.Such a composition is of use in a method of healing an infection in a cavity in bone or other tissue whereby the resorbable aqueous gel is placed in the cavity and allowed to remain there until resorbed, the aqueous phase of the gel containing the water soluble medicament.The medicament is preferably an antibiotic or a methylol transfer antibacterial.

Abstract: The invention provides a method of treatment of the human or animal body comprising the application of an aqueous solution containing a compound of formula I ##STR1## [wherein R.sup.1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula II ##STR2## in which R.sup.1 is as defined above] to human or animal tissue subjected to surgical treatment whereby the incidence of adhesion formation is eliminated or substantially reduced or whereby existing adhesions are at least substantially detached or unblocked. There is also provided a solution for use in the above method.

Abstract: The invention provides compositions comprising oleum hyoscyami together with a pharmaceutical carrier or excipient and a method for the prevention or treatment of scar tissue whereby existing scar tissue or a wound or surgical incision is treated topically with oleum hyoscyami.

Abstract: The present invention provides a method of combatting endotoxaemia whereby there is administered to a patient an effective amount of a compound of the formula: ##STR1## where R.sup.1 is hydrogen or an alkyl group with 1-6 carbon atoms and R.sup.2 is hydrogen or an alkyl group with 1-6 carbon atoms or a group of formula: ##STR2## R.sup.1 is preferably hydrogen and R.sup.2 is preferably hydrogen or a group of formula II; the most preferred compound is bis-(1,1-dioxo-perhydro-1,2,4-thiadiazin-4-yl)-methane.