Patents by Inventor Roman Bielski

Roman Bielski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6225132
    Abstract: A method for detecting an analyte of interest present in a mixture at an ultralow concentration includes selecting a radioactive derivatizing agent comprising a multiphoton-emitting radioisotope moiety and a moiety reactive with the analyte of interest, the radioisotope moeity being bound to the derivatizing agent by a bond that is stable under the conditions employed in the other steps of the method, derivatizing the analyte of interest with the derivatizing agent, separating the analyte of interest from other components of the mixture by chromatography, and detecting the analyte of interest using multiphoton detection. The derivatizing step may be performed before or after fractionation. A radiophore for multiphoton emission enhanced chromatography has a first moeity bound to a multiphoton-emitting radioisotope, and a second moiety that is reactive with a functional group of an analyte of interest.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: May 1, 2001
    Assignee: BioTraces, Inc.
    Inventors: Andrzej K. Drukier, Roman Bielski
  • Patent number: 6011263
    Abstract: This invention is related to the measurement of flow rates and component fractions of individual phases of a composite fluid. More particularly, the invention is directed toward apparatus and methods for determining the volumetric flow rate or mass flow of one or more phases of a fluid by measuring the activity of one or more specific radioactive isotopes affected by a specific phase of the flowing fluid stream. Phase isotopes are deposited upon one or more inserts, and the inserts are positioned within the multiphase fluid flow. Each phase isotope is soluble in only one phase of the multi-phase flow. The rate at which each phase isotope is washed from an insert by each specific fluid phase is then measured by detecting the rate of decrease of preferably photon activity from an insert. Phase flow parameters, including volumetric flow rate and mass flow rate, are then determined for each fluid phase from the measured rate at witch the corresponding phase isotope is washed from an insert.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: January 4, 2000
    Inventors: Roman Bielski, John Carter
  • Patent number: 5880375
    Abstract: This invention is related to the measurement of flow rates and component fractions of individual phases of a composite fluid. More particularly, the invention is directed toward apparatus and methods for determining the volumetric flow rate or mass flow of one or more phases of a fluid by measuring the activity, as a function of time, of one or more specific radioactive isotopes affected by a specific phase of the flowing fluid stream. Radioactive phase isotope material is deposited upon one or more inserts, and each deposition of phase isotope material is coated with a corresponding phase coating. Each phase isotope and corresponding phase coating is soluble in only one phase of the multi-phase flow. The inserts are then inserted into the multi-phase flow, and the time required for each flow phase to wash the corresponding phase coating from the insert is measured by the release of the corresponding phase isotope into the flow stream.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: March 9, 1999
    Inventors: Roman Bielski, John Carter
  • Patent number: 5854084
    Abstract: A method for detecting an analyte of interest present in a mixture at an ultralow concentration includes selecting a radioactive derivatizing agent comprising a multiphoton-emitting radioisotope moiety and a moiety reactive with the analyte of interest, the radioisotope moeity being bound to the derivatizing agent by a bond that is stable under the conditions employed in the other steps of the method, derivatizing the analyte of interest with the derivatizing agent, separating the analyte of interest from other components of the mixture by chromatography, and detecting the analyte of interest using multiphoton detection. The derivatizing step may be performed before or after fractionation. A radiophore for multiphoton emission enhanced chromatography has a first moeity bound to a multiphoton-emitting radioisotope, and a second moiety that is reactive with a functional group of an analyte of interest.
    Type: Grant
    Filed: July 12, 1996
    Date of Patent: December 29, 1998
    Assignee: BioTraces, Inc.
    Inventors: Andrzej K. Drukier, Roman Bielski
  • Patent number: 5240497
    Abstract: Alkali-free layers of pure metals such as copper, nickel and cobalt were deposited on noble metal or noble metal sensitized substrates by electroless deposition using pure quaternary ammonium hydroxides or quaternary phosphonium hydroxides to generate the hydroxyl ion (OH.sup.-) needed to produce electrons for the metal reduction.Using the new alkaline-free electroless compositions, uniform, continuous and reproducible metal layers were selectively deposited with excellent electrical properties. With the improved compositions and process, nanosize copper lines having widths in the range of 100 to 500 nm were prepared.
    Type: Grant
    Filed: October 8, 1991
    Date of Patent: August 31, 1993
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Yosef Y. Shacham, Roman Bielski