Patents by Inventor Roman Sakowicz

Roman Sakowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of screening for modulators of cell proliferation and methods of diagnosing cell proliferation states
    Publication number: 20100261160
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Application
    Filed: August 10, 2006
    Publication date: October 14, 2010
    Applicant: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • COMPOSITIONS AND ASSAYS UTILIZING ADP OR PHOSPHATE FOR DETECTING PROTEIN MODULATORS
    Publication number: 20090117534
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Application
    Filed: October 17, 2008
    Publication date: May 7, 2009
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Plus end-directed microtubule motor required for chromosome congression
    Publication number: 20090076248
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
    Type: Application
    Filed: August 22, 2007
    Publication date: March 19, 2009
    Applicant: The Regents of the University of California
    Inventors: Kenneth W. Wood, Roman Sakowicz, Lawrence S.B. Goldstein, Don W. Cleveland
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Publication number: 20090029344
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Application
    Filed: April 28, 2008
    Publication date: January 29, 2009
    Applicant: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • High throughput sarcomeric assay
    Publication number: 20090023169
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 22, 2009
    Applicant: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Human smooth muscle myosin heavy chain
    Patent number: 7462482
    Abstract: The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: December 9, 2008
    Assignee: Cytokinetics, Inc.
    Inventors: Fady Malik, Christophe Beraud, Richard Freedman, Andrew Craven, Roman Sakowicz, James Hartman
  • Methods for screening and therapeutic applications of kinesin modulators
    Publication number: 20080182271
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Application
    Filed: January 14, 2008
    Publication date: July 31, 2008
    Applicant: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 7378254
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: May 27, 2008
    Assignee: Cytokinetics
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Method for identifying kinesin inhibitors
    Patent number: 7341845
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: March 11, 2008
    Assignee: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • High throughput sarcomeric assay
    Publication number: 20070259390
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: April 23, 2007
    Publication date: November 8, 2007
    Applicant: Cytokinetics,Inc.
    Inventors: James Hartman, Fady Malik, Roman Sakowicz, Jeffrey Finer
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Publication number: 20070254310
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Application
    Filed: January 18, 2007
    Publication date: November 1, 2007
    Applicant: Cytokinetics, Inc.
    Inventors: Jeffrey Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Plus end-directed microtubule motor required for chromosome congression
    Patent number: 7276331
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: October 2, 2007
    Assignee: The Regents of the University of California
    Inventors: Kenneth W. Wood, Roman Sakowicz, Lawrence S. B. Goldstein, Don W. Cleveland
  • Motor proteins and methods for their use
    Patent number: 7247473
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: July 24, 2007
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Andrew Craven, Ming Yu, Roman Sakowicz, Umesh A. Patel, Katherine A. Davies
  • Methods for treating congestive heart failure
    Patent number: 7214503
    Abstract: The present invention provides high throughput screening methods for characterizing compounds that modulate the biological activity of a biochemically functional sarcomere. Compounds characterized by such methods are useful for treating congestive heart failure.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: May 8, 2007
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 7202051
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: April 10, 2007
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Methods for screening and therapeutic applications for kinesin modulators
    Publication number: 20060094074
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Application
    Filed: December 15, 2005
    Publication date: May 4, 2006
    Applicant: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • Plus end-directed microtubule motor required for chromosome congression
    Patent number: 7009043
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 7, 2006
    Assignee: The Regents of the University of California
    Inventors: Kenneth W. Wood, Roman Sakowicz, Lawrence S. B. Goldstein, Don W. Cleveland
  • Methods for screening and therapeutic applications of kinesin modulators
    Patent number: 7005272
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: February 28, 2006
    Assignee: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • WASP and N-WASP constructs and methods of expressing such constructs
    Publication number: 20060024786
    Abstract: WASP and N-WASP proteins are provided that can be expressed in soluble form, including fusion proteins that contain full-length WASP and N-WASP. The proteins retain at least partial activity of full length WASP or N-WASP and some of the proteins fully recapitulate the activity of full-length WASP and N-WASP. Methods for expressing full-length WASP and N-WASP are also provided.
    Type: Application
    Filed: June 10, 2005
    Publication date: February 2, 2006
    Applicant: Cytokinetics, Inc.
    Inventors: Nenad Tomasevic, Alan Russell, Manping Wang, Roman Sakowicz, Christophe Beraud
  • Purification of Arp2/3 complex and compositions containing purified Arp2/3 complex
    Publication number: 20060014266
    Abstract: Methods for rapidly purifying Arp2/3 complex are provided. Compositions containing purified Arp2/3 complex that is characterized by having equal stoichiometry of the subunits are also disclosed.
    Type: Application
    Filed: June 10, 2005
    Publication date: January 19, 2006
    Applicant: Cytokinetics, Inc.
    Inventors: Nenad Tomasevic, Roman Sakowicz