Patents by Inventor Ron Weiss

Ron Weiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10210884
    Abstract: Systems and methods facilitating removal of content from audio files are described. A method includes identifying a sound recording in a first audio file, identifying a reference file having at least a defined level of similarity to the sound recording, and processing the first audio file to remove the sound recording and generate a second audio file. In some embodiments, winner-take-all coding and Hough transforms are employed for determining alignment and rate adjustment of the reference file in the first audio file. After alignment, the reference file is filtered in the frequency domain to increase similarity between the reference file and the sound recording. The frequency domain representation (FR) of the filtered version is subtracted from the FR first audio and the result converted to a time representation of the second audio file. In some embodiments, spectral subtraction is also performed to generate a further improved second audio file.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: February 19, 2019
    Assignee: Google LLC
    Inventors: Richard Francis Lyon, Ron Weiss, Thomas Chadwick Walters
  • Publication number: 20190032141
    Abstract: Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure are designed to incorporate multiple genetic circuits integrated together by transcriptional or translational control. Multiple inputs can be sensed simultaneously by coupling their detection to different portions of the genetic circuit such that the output molecule is produced only when the correct input profile of miRNAs is detected. The genetic circuits and cell state classifiers may be used in various applications (e.g., therapeutic or diagnostic applications).
    Type: Application
    Filed: July 31, 2017
    Publication date: January 31, 2019
    Inventors: Ron Weiss, Jin Huh
  • Publication number: 20190032054
    Abstract: Provided herein are genetic circuits and encoded RNA transcripts that produce an output molecule in response to an RNA cleavage event that removes a degradation signal. In some embodiments, the genetic circuits described herein may be used for detecting RNA cleaver activities (e.g., in a cell). Methods of using the genetic circuits described herein in diagnostic or therapeutic applications are also provided.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 31, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Breanna E. DiAndreth
  • Publication number: 20180296702
    Abstract: Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 18, 2018
    Applicants: Massachusetts Institute of Technology, Kyoto University
    Inventors: Ron Weiss, Liliana Wroblewska, Velia Siciliano, Tasuku Kitada, Maria Hottelet Foley, Katie Bodner, Hirohide Saito, Kei Endo, Darrell J. Irvine, Tyler Wagner, Jacob Becraft
  • Patent number: 10100318
    Abstract: Aspects of the invention relate to reconfigurable chassis that allow for rapid construction and optimization of biocircuits.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: October 16, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Jonathan William Babb, Ron Weiss, Thomas Knight, Adam Rubin
  • Publication number: 20180251789
    Abstract: Aspects of the disclosure relate to synthetic regulatory systems composed of a multifunctional clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) nuclease and at least two distinct guide RNAs (gRNAs). The synthetic regulatory system modulates cleavage and transcription, including repression and activation, in a mammalian cell such as a human cell.
    Type: Application
    Filed: September 1, 2016
    Publication date: September 6, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Samira Kiani, Ron Weiss, Mohammad Reza Ebrahimkhani
  • Publication number: 20180170990
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: July 27, 2017
    Publication date: June 21, 2018
    Inventors: Stephane BANCEL, Tirtha CHAKRABORTY, Antonin DE FOUGEROLLES, Sayda M. ELBASHIR, Matthias JOHN, Atanu ROY, Susan WHORISKEY, Paul HATALA, Jason P. SCHRUM, Kenechi EJEBE, Jeff Lynn ELLSWORTH, Justin GUILD, Ron WEISS, Kristy M. WOOD
  • Publication number: 20170347819
    Abstract: A beverage container comprising a stem having an upper and a lower end, a cup having an upper opening and a lower bowl portion, and a base having a tapered upper end with a diameter that widens evenly along its length towards a lower end until the diameter is at least equal to a diameter of the upper opening of the cup. The upper end of the stem is attached to the cup at a point centered on the bowl portion of the cup. The upper end of the base is removably attached at to the lower end of the stem, the lower end of the base being capable of securely covering the upper opening when not attached to the stem.
    Type: Application
    Filed: November 9, 2016
    Publication date: December 7, 2017
    Inventor: Ron Weiss
  • Publication number: 20170306351
    Abstract: Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
    Type: Application
    Filed: May 9, 2017
    Publication date: October 26, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Patrick Guye, Ron Weiss, Mohammad Reza Ebrahimkhani
  • Patent number: 9790487
    Abstract: Aspects herein relate to composition, and related methods, for isolating and assembling DNA molecules without intermediate cloning steps.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: October 17, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Jonathan William Babb, Shuo Cory Li, Thomas Knight, Ron Weiss
  • Publication number: 20170256271
    Abstract: Systems and methods facilitating removal of content from audio files are described. A method includes identifying a sound recording in a first audio file, identifying a reference file having at least a defined level of similarity to the sound recording, and processing the first audio file to remove the sound recording and generate a second audio file. In some embodiments, winner-take-all coding and Hough transforms are employed for determining alignment and rate adjustment of the reference file in the first audio file. After alignment, the reference file is filtered in the frequency domain to increase similarity between the reference file and the sound recording. The frequency domain representation (FR) of the filtered version is subtracted from the FR first audio and the result converted to a time representation of the second audio file. In some embodiments, spectral subtraction is also performed to generate a further improved second audio file.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 7, 2017
    Inventors: Richard Francis Lyon, Ron Weiss, Thomas Chadwick Walters
  • Publication number: 20170211061
    Abstract: The disclosure provides novel large serine recombinases and their respective recognition sites, as well as libraries of orthogonal recombinase recognition sites. Uses of the large serine recombinases, recognition sites, and libraries of orthogonal recombinase recognition sites also are provided.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Applicants: Massachusetts Institute of Technology, INRIA (French Institute for Research in Computer Science and Automation)
    Inventors: RON WEISS, Xavier Cesar Duportet, Gregory Batt, Yinqing Li
  • Patent number: 9677085
    Abstract: Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: June 13, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick Guye, Ron Weiss, Mohammad Reza Ebrahimkhani
  • Patent number: 9675668
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 13, 2017
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • Patent number: 9679579
    Abstract: Systems and methods facilitating removal of content from audio files are described. A method includes identifying a sound recording in a first audio file, identifying a reference file having at least a defined level of similarity to the sound recording, and processing the first audio file to remove the sound recording and generate a second audio file. In some embodiments, winner-take-all coding and Hough transforms are employed for determining alignment and rate adjustment of the reference file in the first audio file. After alignment, the reference file is filtered in the frequency domain to increase similarity between the reference file and the sound recording. The frequency domain representation (FR) of the filtered version is subtracted from the FR first audio and the result converted to a time representation of the second audio file. In some embodiments, spectral subtraction is also performed to generate a further improved second audio file.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: June 13, 2017
    Assignee: Google Inc.
    Inventors: Richard Francis Lyon, Ron Weiss, Thomas Chadwick Walters
  • Publication number: 20170145426
    Abstract: Provided is a modular construction of synthetic gene circuits in mammalian cells using TALE transcriptional repressors.
    Type: Application
    Filed: March 6, 2015
    Publication date: May 25, 2017
    Inventors: Zhen XIE, Ron WEISS, Yinqing LI, Yun JIANG, Weixi LIAO, He CHEN
  • Publication number: 20170130220
    Abstract: Aspects herein relate to composition, and related methods, for isolating and assembling DNA molecules without intermediate cloning steps.
    Type: Application
    Filed: September 21, 2016
    Publication date: May 11, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Jonathan William Babb, Shuo Cory Li, Thomas Knight, Ron Weiss
  • Publication number: 20170044570
    Abstract: The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex.
    Type: Application
    Filed: August 30, 2016
    Publication date: February 16, 2017
    Inventors: Ron Weiss, Ihor Lemischka, Priscilla E. M. Purnick, Christoph Schaniel, Miles Miller, Patrick Guye
  • Publication number: 20170028085
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: October 14, 2016
    Publication date: February 2, 2017
    Inventors: Stephane BANCEL, Tirtha CHAKRABORTY, Antonin DE FOUGEROLLES, Sayda M. ELBASHIR, Matthias JOHN, Atanu ROY, Susan WHORISKEY, Kristy M. Wood, Paul HATALA, Jason P. SCHRUM, Kenechi EJEBE, Jeff Lynn ELLSWORTH, Justin GUILD, Ron WEISS
  • Patent number: 9504734
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: November 29, 2016
    Assignee: ModernaTX, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild, Ron Weiss