Patents by Inventor Ronald Albright

Ronald Albright has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Treating Pathological Calcification and Ossification
    Publication number: 20220152163
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 19, 2022
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions for Treating Pathological Calcification Conditions, and Methods Using Same
    Publication number: 20220133854
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Application
    Filed: July 7, 2021
    Publication date: May 5, 2022
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions and methods for treating pathological calcification and ossification
    Patent number: 11266722
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: March 8, 2022
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • COMPOSITIONS FOR TREATING PATHOLOGICAL CALCIFICATION CONDITIONS, AND METHODS USING SAME
    Publication number: 20210401950
    Abstract: The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of ENPP4.
    Type: Application
    Filed: August 19, 2021
    Publication date: December 30, 2021
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions and methods for treating nonsteroidal anti-inflammatory drug (NSAID) associated coagulopathy, thrombocytopenia, glanzmann's thrombasthenia, and/or thrombosis
    Patent number: 11123408
    Abstract: The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of ENPP4.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: September 21, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions for treating pathological calcification conditions, and methods using same
    Patent number: 11090359
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: August 17, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Methods for treating pseudoxanthoma elasticum (PXE)
    Patent number: 10960050
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: March 30, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions for treating pathological calcification conditions, methods, and host cells using the same
    Patent number: 10960049
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 30, 2021
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions for Treating Pathological Calcification Conditions, and Methods Using Same
    Publication number: 20200237865
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Application
    Filed: March 25, 2020
    Publication date: July 30, 2020
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions and Methods for Treating Pathological Calcification and Ossification
    Publication number: 20200237882
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 30, 2020
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions for Treating Pathological Calcification Conditions, and Methods Using Same
    Publication number: 20200138905
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Application
    Filed: December 27, 2019
    Publication date: May 7, 2020
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions and methods for treating pathological calcification and ossification
    Patent number: 10624958
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: April 21, 2020
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions for treating pathological calcification conditions, and methods using same
    Patent number: 10583170
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: March 10, 2020
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions for treating pathological calcification conditions, and methods using same
    Patent number: 10517927
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: December 31, 2019
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions for Treating Pathological Calcification Conditions, and Methods Using Same
    Publication number: 20190231849
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Inventors: Demetrios BRADDOCK, Ronald ALBRIGHT
  • Compositions for treating pathological calcification conditions, and methods using same
    Patent number: 10357541
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: July 23, 2019
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • COMPOSITIONS AND METHODS FOR TREATING NONSTEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) ASSOCIATED COAGULOPATHY, THROMBOCYTOPENIA, GLANZMANN'S THROMBASTHENIA, AND/OR THROMBOSIS
    Publication number: 20190167768
    Abstract: The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of ENPP4.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 6, 2019
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions and methods for treating platelet storage pool deficiency, gray platelet syndrome and quebec platelet disorder
    Patent number: 10258671
    Abstract: The present invention relates to compositions and methods for treating diseases of coagulation using a NPP4 polypeptide.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: April 16, 2019
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions for treating pathological calcification conditions, and methods using same
    Patent number: 10213484
    Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: February 26, 2019
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Compositions and Methods for Treating Pathological Calcification and Ossification
    Publication number: 20180318401
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Application
    Filed: July 12, 2018
    Publication date: November 8, 2018
    Inventors: Demetrios Braddock, Ronald Albright