Patents by Inventor Ronald James Christie

Ronald James Christie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220371973
    Abstract: The present invention provides conjugates of a first polypeptide and a second polypeptide wherein the link between the first polypeptide and the second polypeptide comprises the following moiety.
    Type: Application
    Filed: July 2, 2020
    Publication date: November 24, 2022
    Inventors: Jia Lin, Ronald James Christie, Changshou Gao
  • Publication number: 20220160882
    Abstract: The present disclosure relates to a method of conjugating a compound of formula (I) O 5 R1-Q (ZL-COn-X—N O (I) with a polypeptide comprising at least one thiol group and molecules obtained from said method.
    Type: Application
    Filed: November 16, 2021
    Publication date: May 26, 2022
    Inventors: Ronald James CHRISTIE, Changshou GAO, Nazzareno DIMASI
  • Publication number: 20210283141
    Abstract: A conjugate of formula I: wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain and each of RLL1 and RLL2 comprise the group:
    Type: Application
    Filed: May 24, 2019
    Publication date: September 16, 2021
    Inventors: Luke MASTERSON, Balakumar VIJAYAKRISHNAN, Ronald James CHRISTIE
  • Publication number: 20200206359
    Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.
    Type: Application
    Filed: May 25, 2018
    Publication date: July 2, 2020
    Inventors: Ronald James Christie, Changshou Gao, Andre Henri St. Amant, Javier Read de Alaniz
  • Publication number: 20170304460
    Abstract: The present disclosure relates to a method of conjugating a compound of formula (I) with a polypeptide comprising at least one thiol group and molecules obtained from said method.
    Type: Application
    Filed: October 1, 2015
    Publication date: October 26, 2017
    Inventors: Ronald James CHRISTIE, Changshou GAO, Nazzareno DIMASI
  • Patent number: 9278075
    Abstract: A composition of matter for use in encapsulating a drug is expressed by formula (1) or formula (2): wherein R1 and R2 are each independently a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms; A is a hydrophilic polymer chain; L1 and L3 are each a linking group; B is a cation-containing group; R3 is a side chain of an amino acid; z is an integer of 5 to 500; x is an integer of 40% or more of z; y is 0 or a positive integer; z-x-y is 0 or a positive integer; p is an integer of 1 to 10; and q is an integer of 1 to 10.
    Type: Grant
    Filed: January 16, 2012
    Date of Patent: March 8, 2016
    Assignees: NANOCARRIER CO., LTD., THE UNIVERSITY OF TOKYO
    Inventors: Kazunori Kataoka, Ronald James Christie, Nobuhiro Nishiyama, Kanjiro Miyata, Shigeto Fukushima, Yu Matsumoto, Takahiro Nomoto, Yasuki Kato
  • Publication number: 20140017328
    Abstract: A composition of matter for use in encapsulating a drug is expressed by formula (1) or formula (2): wherein R1 and R2 are each independently a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms; A is a hydrophilic polymer chain; L1 and L3 are each a linking group; B is a cation-containing group; R3 is a side chain of an amino acid; z is an integer of 5 to 500; x is an integer of 40% or more of z; y is 0 or a positive integer; z-x-y is 0 or a positive integer; p is an integer of 1 to 10; and q is an integer of 1 to 10.
    Type: Application
    Filed: January 16, 2012
    Publication date: January 16, 2014
    Applicants: NANOCARRIER CO., LTD., THE UNIVERSITY OF TOKYO
    Inventors: Kazunori Kataoka, Ronald James Christie, Nobuhiro Nishiyama, Kanjiro Miyata, Shigeto Fukushima, Yu Matsumoto, Takahiro Nomoto, Yasuki Kato