Abstract: A device is provided for self-sampling a body cavity, in particular the cervix, and a method is provided to use the device to obtain samples from the cervix for testing for the presence of human papillomavirus (HPV) DNA. The device includes elongated flexible bristles attached to a handle to form a mop-like sampling member. The sampling member is rotated to mop the cervix and obtain a sample of cervical cells on the elongated bristles. The sampling device is then withdrawn from the vaginal cavity and the sample is sent for analysis.

Abstract: A device is provided for self-sampling a body cavity, in particular the cervix, and a method is provided to use the device to obtain samples from the cervix for testing for the presence of human papillomavirus (HPV) DNA. The device includes elongated flexible bristles attached to a handle to form a mop-like sampling member. The sampling member is rotated to mop the cervix and obtain a sample of cervical cells on the elongated bristles. The sampling device is then withdrawn from the vaginal cavity and the sample is sent for analysis.

Abstract: A device is provided for self-sampling a body cavity, in particular the cervix, and a method is provided to use the device to obtain samples from the cervix for testing for the presence of human papillomavirus (HPV) DNA. The device includes elongated flexible bristles attached to a handle to form a mop-like sampling member. The sampling member is rotated to mop the cervix and obtain a sample of cervical cells on the elongated bristles. The sampling device is then withdrawn from the vaginal cavity and the sample is sent for analysis.

Abstract: A device is provided for self-sampling a body cavity, in particular the cervix, and a method is provided to use the device to obtain samples from the cervix for testing for the presence of human papillomavirus (HPV) DNA. The device includes elongated flexible bristles attached to a handle to form a mop-like sampling member. The sampling member is slidably disposed within an annular shield for insertion into the vaginal cavity and for positioning in contact with the cervix. After the shield is located in position, the shield is partially withdrawn to expose the elongated bristles to the cervix. The sampling member is rotated to mop the cervix and obtain a sample of cervical cells on the elongated bristles. The sampling device is then withdrawn from the vaginal cavity and the sample is sent for analysis.

Abstract: A cryosurgical instrument having a cooling mode and a rapid warming or defrost mode is provided with a first conduit through which refrigerant gas is metered to undergo a Joule-Thomson or isoenthalpic expansion adjacent the tip of the instrument to cool the tip. The tip is defrosted by admitting a larger volume of unexpanded gas from the source to the tip through a second conduit and back pressurizing the gas to provide a sufficient balance to cause it to undergo heat exchange with the tip. Valve means, upstream from the tip is used to selectively control the gas flow path through either the first or second conduit. The tip is in communication with an exhaust port constantly open to the atmosphere. A pulse valve sensitive to gas volume in the exhaust line is positioned downstream from the tip between the tip and exhaust port to aid in back pressurizing the unexpanded gas by partially blocking the exhaust line.

Abstract: A cryosurgical instrument having a purge cycle of indeterminate duration, separate and apart from its cooling and warming modes, which can be conducted with a refrigerant consisting of a low pressure unsaturated or saturated gas. During the purge cycle, the pressure of the refrigerant gas is regulated to a level below that which is required to effect a Joule-Thomson expansion of the gas upon its entrance into an expansion chamber adjacent the tip of the instrument while simultaneously exhausting the effluent to the atmosphere through an exhaust valve actuated by a footswitch.