Patents by Inventor Rosemarie Kelly

Rosemarie Kelly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10934577
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: March 2, 2021
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, MERCK & CO., INC.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20170356034
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 14, 2017
    Applicants: Rutgers, The State University of New Jersey, Merck & Co., Inc.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Patent number: 9657334
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 23, 2017
    Assignees: Rutgers, The State University of New Jersey, Merck & Co., Inc.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20150125856
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: June 16, 2014
    Publication date: May 7, 2015
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Patent number: 8753819
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: June 17, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer Nielsen Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20100247561
    Abstract: The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1, uses of such polypeptides, and expression systems for producing such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full-length polypeptide is referred to herein as full-length “ORF0657n”. Polypeptides containing the amino acid sequence of SEQ ID NO: 1 were found to produce a protective immune response against S. aureus.
    Type: Application
    Filed: April 30, 2010
    Publication date: September 30, 2010
    Inventors: Annaliesa S. Anderson, Kathrin Ute Jansen, Rosemarie Kelly, Loren D. Schultz, Donna L. Montgomery, William L. McClements
  • Publication number: 20100203588
    Abstract: The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxylamino acids was found to produce a protective immune response against S. aureus.
    Type: Application
    Filed: March 9, 2010
    Publication date: August 12, 2010
    Inventors: Rosemarie Kelly, Loren D. Schultz, Mark A. Miller, Mark D. Yeager, Tessie McNeely
  • Patent number: 7718182
    Abstract: The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: May 18, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Rosemarie Kelly, Loren D. Schultz, Mark A. Miller, Mark D. Yeager, Tessie McNeely
  • Publication number: 20100075302
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: July 26, 2006
    Publication date: March 25, 2010
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, MERCK & CO.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer Nielsen Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20080131447
    Abstract: The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus.
    Type: Application
    Filed: January 17, 2006
    Publication date: June 5, 2008
    Inventors: Rosemarie Kelly, Loren D. Schultz, Mark A. Miller, Mark D. Yeager, Tessie McNeeley
  • Publication number: 20060177462
    Abstract: The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1, uses of such polypeptides, and expression systems for producing such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length <i>S. aureus</i> polypeptide. The full-length polypeptide is referred to herein as full-length “ORF0657n”. Polypeptides containing the amino acid sequence of SEQ ID NO: 1 were found to produce a protective immune response against <i>S. aureus</i>.
    Type: Application
    Filed: July 22, 2004
    Publication date: August 10, 2006
    Inventors: Annaliesa Anderson, Kathrin Jansen, Rosemarie Kelly, Loren Schulz, Donna Montgomery, William McClements
  • Patent number: 5908753
    Abstract: There is disclosed a procedure for DNA-mediated transformation of Candida albicans by electroporation utilizing lithium acetate and dithiothreitol to weaken the cell wall structure and optimize the yield of transformants.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: June 1, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Rosemarie Kelly, Elizabeth A. Register, Myra B. Kurtz, John R. Thompson
  • Patent number: 5821353
    Abstract: DNA molecules encoding proteins involved in biosynthesis of 1,3-beta-D glucan are identified, cloned, expressed and used in in vitro assays to screen for antifungal compounds, including compounds that affect cell wall biosynthesis. The invention includes but is not limited to the purified DNA molecules, assays employing the DNA molecules, proteins encoded by the DNA molecules, cells expressing the DNA molecules and altered forms of the molecules.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: October 13, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Cameron M. Douglas, Gary L. Chrebet, Joseph Clemas, Mohammed El-Sherbeini, Forrest Foor, Jennifer Nielsen Kahn, Rosemarie Kelly, Jean A. Marrinan, Nancy R. Morin, Janet C. Onishi, Stephen Authur Parent, Naasa M. Ramadan, Elizabeth A. Register, Gan-Ju Shei
  • Patent number: 5789222
    Abstract: There is disclosed an isolated gene coding for an enzyme involved in proline biosynthesis in Zalerion arboricola. There is also disclosed a method of using the gene to produce a strain of Z. arboricola containing high titers of a desirable fermentation product.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: August 4, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Rosemarie Kelly, Prakash S. Masurekar, Elizabeth A. Register