Patents by Inventor Ross A. Tubo

Ross A. Tubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11857576
    Abstract: The present disclosure provides compositions and methods for repairing cartilage defects.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: January 2, 2024
    Assignee: Vericel Corporation
    Inventors: Ross A. Tubo, Xing Zhao
  • Publication number: 20210052661
    Abstract: The present disclosure provides compositions and methods for repairing cartilage defects.
    Type: Application
    Filed: December 7, 2018
    Publication date: February 25, 2021
    Inventors: Ross A. Tubo, Xing Zhao
  • Patent number: 8481022
    Abstract: Methods and compositions for treating an autoimmune disease, such as new onset type 1 diabetes (T1D) in a subject using autologous or allogeneic mesenchymal stem cells administered to the subject prior to autoimmune-induced complete depletion of insulin-producing pancreatic beta cells, e.g., within six months of new onset type 1 diabetes (T1D) diagnosis or prior to the onset of disease in a subject determined to be at high risk for T1D.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: July 9, 2013
    Assignee: Genzyme Corporation
    Inventors: Tracey Lodie, Michele Youd, Ross Tubo, Scott Eisenbeis
  • Publication number: 20120121611
    Abstract: Methods and compositions for treating an autoimmune disease, such as new onset type 1 diabetes (T1D) in a subject using autologous or allogeneic mesenchymal stem cells administered to the subject prior to autoimmune-induced complete depletion of insulin-producing pancreatic beta cells, e.g., within six months of new onset type 1 diabetes (T1D) diagnosis or prior to the onset of disease in a subject determined to be at high risk for T1D.
    Type: Application
    Filed: July 28, 2011
    Publication date: May 17, 2012
    Inventors: Tracey LODIE, Michele Youd, Ross Tubo, Scott Eisenbeis
  • Publication number: 20110281814
    Abstract: The invention relates to methods and compositions for treating a subject afflicted with breast cancer using a CX-CR4 antagonist and optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: January 28, 2010
    Publication date: November 17, 2011
    Inventors: Ajeeta Dash, Ross Tubo
  • Publication number: 20090324609
    Abstract: Methods and compositions for treating an autoimmune disease, such as new onset type 1 diabetes (T1D) in a subject using autologous or allogeneic mesenchymal stem cells administered to the subject prior to autoimmune-induced complete depletion of insulin-producing pancreatic beta cells, e.g., within six months of new onset type 1 diabetes (T1D) diagnosis or prior to the onset of disease in a subject determined to be at high risk for T1D.
    Type: Application
    Filed: August 8, 2008
    Publication date: December 31, 2009
    Applicant: Genzyme Corporation
    Inventors: Tracey Lodie, Michele Youd, Ross Tubo, Scott Eisenbeis
  • Patent number: 5786217
    Abstract: Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extracellular matrix components, type II collagen and sulfated proteoglycans. The proliferated cells then are seeded into a pre-shaped well having a cell contacting, cell abhesive surface. The cells cultured in the well redifferentiate and begin to secrete cartilage-specific extracellular matrix again. Accordingly, essentially unlimited amounts of synthetic cartilage may be prepared from small samples of biopsy tissue. Also provided are methods for surgically repairing articular cartilage defects in mammals using the synthetic cartilage prepared in accordance with the invention.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: July 28, 1998
    Assignee: Genzyme Corporation
    Inventors: Ross A. Tubo, Leesa M. Barone, Courtney A. Wrenn
  • Patent number: 5723331
    Abstract: Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extracellular matrix components, type II collagen and sulfated proteoglycans. The proliferated cells then are seeded into a pre-shaped well having a cell contacting, cell abhesive surface. The cells cultured in the well redifferentiate and begin to secrete cartilage-specific extracellular matrix again. Accordingly, essentially unlimited amounts of synthetic cartilage may be prepared from small samples of biopsy tissue. Also provided are methods for surgically repairing articular cartilage defects in mammals using the synthetic cartilage prepared in accordance with the invention.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 3, 1998
    Assignee: Genzyme Corporation
    Inventors: Ross A. Tubo, Leesa M. Barone, Courtney A. Wrenn
  • Patent number: 5145770
    Abstract: Disclosed is a method of cryopreserving a sheet of living, cultured epithelial cells for use as a skin wound dressing. The method ensures that the integrity of the sheet will be maintained, and it preserves a significant number of cells in a mitotically competent, physiologically healthy form. It involves use of a non cell penetrating cryoprotectant and certain freezing and thawing conditions.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: September 8, 1992
    Assignee: BioSurface Technology, Inc.
    Inventors: Ross A. Tubo, Susan F. Schaeffer, Alexander Schermer, Richard Odessey
  • Patent number: 5100676
    Abstract: The viability of cohesive sheets of cultured epithelial cells such as keratinocytes used as wound dressings is maintained or improved by storage at a temperature within the range of 8.degree.-25.degree. C., preferably 13.degree.-23.degree. C., for periods greater than 8 hours, preferably up to 26 hours. This method and the resulting product permits a significant increase in the shipping radius of cultured dressings manufactured in a central facility, and increases flexibility in scheduling of shipments and surgical procedures.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: March 31, 1992
    Assignee: Biosurface Technology, Inc.
    Inventors: Richard Odessey, Alexander Schermer, Susan F. Schaeffer, Ross A. Tubo
  • Patent number: 5040677
    Abstract: Disclosed is a container for the storage and distribution of a cultured epithelial, generally planar, living, skin wound dressing that allows the dressing to be gently removed by lifting perpendicular to a support surface in the container. The design minimizes handling of the graft dressing thereby promoting cell viability.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: August 20, 1991
    Assignee: Biosurface Technology, Inc.
    Inventors: Ross A. Tubo, Richard Odessey