Patents by Inventor ROY GEOFFREY SARGENT

ROY GEOFFREY SARGENT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11339385
    Abstract: The technology relates to a composition for tethering donor DNA to a nuclease, the composition comprising a nucleic acid comprising donor DNA and a consensus sequence for a DNA binding domain; and at least one of: a fusion protein comprising a nuclease coupled to a DNA binding domain for binding the consensus sequence; and a nucleic acid encoding the fusion protein.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: May 24, 2022
    Assignee: GeneTether, Inc.
    Inventor: Roy Geoffrey Sargent
  • Publication number: 20210095310
    Abstract: Provided herein are vectors, compositions and methods for treating and diagnosing breast cancer. In exemplary embodiments, the present disclosure provides a vector for the expression of a therapeutic protein, wherein the vector comprises a microRNA binding domain (MBD) that facilitates the expression of the therapeutic protein in breast cancer cells and inhibits the expression of the therapeutic protein in non-breast cancer cells. The present disclosure also provides compositions comprising the vectors and methods of using the vectors for treating and/or diagnosing breast cancer.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 1, 2021
    Inventors: Lukas DC GRUENERT, Gabriel HITCHCOCK, Roy Geoffrey SARGENT
  • Publication number: 20200181567
    Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
    Type: Application
    Filed: October 25, 2019
    Publication date: June 11, 2020
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
  • Patent number: 10501723
    Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: December 10, 2019
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
  • Publication number: 20190309275
    Abstract: The technology relates to a composition for tethering donor DNA to a nuclease, the composition comprising a nucleic acid comprising donor DNA and a consensus sequence for a DNA binding domain; and at least one of: a fusion protein comprising a nuclease coupled to a DNA binding domain for binding the consensus sequence; and a nucleic acid encoding the fusion protein.
    Type: Application
    Filed: March 25, 2019
    Publication date: October 10, 2019
    Inventor: Roy Geoffrey Sargent
  • Publication number: 20170152475
    Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
    Type: Application
    Filed: October 28, 2014
    Publication date: June 1, 2017
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
  • Publication number: 20150232808
    Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
    Type: Application
    Filed: October 28, 2014
    Publication date: August 20, 2015
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
  • Publication number: 20110286978
    Abstract: The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
    Type: Application
    Filed: May 25, 2010
    Publication date: November 24, 2011
    Inventors: Irina V. Klimanskaya, Shi-Jiang Lu, Robert Lanza, Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent, Raymond Page, Tanja Dominko, Christopher Malcuit
  • Publication number: 20110171185
    Abstract: The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
    Type: Application
    Filed: February 4, 2010
    Publication date: July 14, 2011
    Inventors: IRINA V. KLIMANSKAYA, SHI-JIANG LU, ROBERT LANZA, MICHAEL D. WEST, KAREN B. CHAPMAN, ROY GEOFFREY SARGENT, RAYMOND PAGE, TANJA DOMINKO, CHRISTOPHER MALCUIT
  • Publication number: 20110143441
    Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
    Type: Application
    Filed: August 13, 2010
    Publication date: June 16, 2011
    Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
  • Publication number: 20100167404
    Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
    Type: Application
    Filed: August 3, 2006
    Publication date: July 1, 2010
    Applicant: ADVANCED CELL TECHNOLOGY, INC.
    Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
  • Publication number: 20030124505
    Abstract: The invention relates to the use of high-throughput methods for gene targeting, recombination, phenotype screening and biovalidation of drug targets utilizing enhanced homologous recombination (EHR) techniques. These methods utilize robotically driven multichannel pipetters to perform liquid, particle, cell and organism handling, robotically controlled plate and sample handling platforms, magnetic probes and affinity probes to selectively capture nucleic acid hybrids, and thermally regulated plates or blocks for temperature controlled reactions.
    Type: Application
    Filed: March 22, 2000
    Publication date: July 3, 2003
    Inventors: Sarita Kumari Jain, Elizabeth Anne Allen, Sushma Pati, Roy Geoffrey Sargent, David A. Zarling
  • Publication number: 20020152494
    Abstract: A method comprising: a) altering a chromosomal sequence of a donor nucleus of a donor cell by introducing a pair of single-stranded targeting polynucleotides, and a recombinase into said donor nucleus of said donor cell, wherein said pair of targeting polynucleotides are substantially complementary to each other and each comprising a homology clamp that substantially corresponds to or is substantially complementary to a predetermined DNA sequence of said nucleus; and, b) transplanting said nucleus into an oocyte to produce a recombinant zygote.
    Type: Application
    Filed: December 23, 1999
    Publication date: October 17, 2002
    Inventors: ROY GEOFFREY SARGENT, ANNE KATHRYN VALLERGA, SUSHMA PATI, DAVID ALAN ZARLING