Patents by Inventor Rudi Beyerle
Rudi Beyerle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5221680Abstract: Substituted 3-aminosydnonimines of the formula I ##STR1## and pharmacologically acceptable acid addition salts thereof, in which R.sup.1 denotes hydrogen or the radical --COR.sup.4,R.sup.2 denotes alkyl or phenyl alkyl having 1 to 4 C atoms in the alkyl group,R.sup.4 denotes, for example, an aryl radical, and processes and formulations for controlling or preventing cardiovascular diseases by administering an effective amount of such compounds to a host in need thereof.Type: GrantFiled: February 27, 1992Date of Patent: June 22, 1993Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Helmut Bohn
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Patent number: 5204475Abstract: The invention relates to pharmacologically active substituted 3-aminosydnone imines of the general formula I ##STR1## in which n denotes 0 or 1, and their pharmacologically acceptable salts and acid addition salts, and to a process for the preparation of the compounds according to the invention and their use.Type: GrantFiled: July 16, 1991Date of Patent: April 20, 1993Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Helmut Bohn, Melitta Just
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Patent number: 5179206Abstract: Substituted 3-aminosydnone imines of the formula I ##STR1## and their pharmacologically acceptable acid addition salts, in which R.sup.1 denotes e.g. hydrogen;R.sup.2 denotes e.g. an alkyl radical;at least two of the radicals R.sup.3, R.sup.4, R.sup.5 and R.sup.6 denote alkyl radicals and the others denote hydrogen, are prepared by cyclization of a compound of the formula II ##STR2## and, if appropriate, subsequent acylation, and have useful pharmacological properties.Type: GrantFiled: June 7, 1990Date of Patent: January 12, 1993Assignee: Cassella AktiengellschaftInventors: Eckard Kujath, Christian Baumgartner, Karl Schonafinger, Rudi Beyerle, Melitta Just, Helmut Bohn, Jorg Ostrowski
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Patent number: 5166166Abstract: The present invention relates to pharmacologically active substituted 3-dicyclohexylaminosydnone imines of the general formula I ##STR1## and their pharmacologically acceptable acid addition salts, in which R.sup.1 denotes hydrogen or the radical --COR.sup.2 and R.sup.2 denotes (C.sub.1 to C.sub.4)-alkyl, (C.sub.1 to C.sub.4)alkoxy-(C.sub.1 to C.sub.4)alkyl, (C.sub.1 to C.sub.4) alkoxy, (C.sub.1 to C.sub.4)alkoxy-(C.sub.1 to C.sub.4 )alkoxy, (C.sub.5 to C.sub.7)cycloalkyl, phenyl, a phenyl radical which is mono-, di- or trisubstituted by 1 to 3 halogen atoms and/or 1 to 3 alkyl radicals having 1 to 4 C atoms and/or 1 to 3 alkoxy radicals having 1 to 4 C atoms, a nicotinoyl radical or an allylmercaptoacetyl radical, and to a process for the preparation of the compounds according to the invention and their use.Type: GrantFiled: July 16, 1991Date of Patent: November 24, 1992Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Helmut Bohn, Melitta Just
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Patent number: 5120732Abstract: Substituted 3-aminosydnone imines of the formula I ##STR1## and their pharmacologically acceptable acid addition salts, in which A denotes, for example, --CH.sub.2 --,R.sup.1 denotes hydrogen or the radical --COR.sup.5,R.sup.2, R.sup.3 denote alkyl having 1 to 4 C atoms,R.sup.5 denotes, for example, an aliphatic radical having 1 to 4 C atoms,and methods for preparing such compounds by cyclization of a compound of the formula II ##STR2## and if desired subsequent acylation. The invention also includes formulations containing effective amounts of such compounds, and methods for administering same to patients for the control and prophylaxis of cardiovascular disorders.Type: GrantFiled: August 29, 1990Date of Patent: June 9, 1992Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Helmut Bohn, Melitta Just
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Patent number: 5091398Abstract: The 1,2,3,4-oxatriazolium-5-olates of the formula I ##STR1## in which R.sup.1 denotes, for example, (C.sub.2 to C.sub.4)alkyl,R.sup.2 and R.sup.3 denotes (C.sub.1 to C.sub.4)alkyl have useful pharmacological properties.Type: GrantFiled: April 6, 1990Date of Patent: February 25, 1992Assignee: Cassella AktiengellschaftInventors: Karl Schonafinger, Helmut Bohn, Rudi Beyerle, Melitta Just
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Patent number: 5079244Abstract: Substituted 3-aminosydnone imines of the general formula I ##STR1## and their pharmacologically acceptable acid addition salts, in which A denotes an alkylene chain;X denotes one of the groups --O-- or --S--;R.sup.1 denotes e.g. hydrogen;R.sup.2 denotes e.g. an alkyl group,are prepared by cyclization of a compound of the formula II ##STR2## and, if appropriate, subsequent acylation, and have useful pharmacological properties.Type: GrantFiled: June 7, 1990Date of Patent: January 7, 1992Assignee: Cassella AktiengesellschaftInventors: Eckard Kujath, Christian Baumgartner, SchoKarl, Rudi Beyerle, Melitta Just, Helmut Bohn, Jorg Ostrowski
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Patent number: 5043348Abstract: Pyrrolealdehydes of the formula I ##STR1## wherein R and R.sup.1 independently of one another denote hydrogen or alkyl with 1 to 4 C atoms, R.sup.2 denotes alkyl, which is substituted by acylamino of the formula II ##STR2## wherein X stands for an oxygen or sulphur atom and R.sup.3 denotes hydrogen, optionally substituted alkyl or alkylamino, cycloalkyl with 5 to 7 C atoms, optionally substituted phenyl, an amino group or an optionally substituted phenylamio group, and pharmaceutically acceptable acid addition salts thereof, and wherein R.sup.3 cannot represent hydrogen if R and R.sup.1 denote hydrogen and the pyrrole ring is formylated in the 3-position, their preparation and their use.Type: GrantFiled: February 26, 1990Date of Patent: August 27, 1991Assignee: Cassella AktiengesellschaftInventors: Gerhard Zoller, Rudi Beyerle, Ursula Schindler
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Patent number: 5015659Abstract: The present invention relates to thienylacetic acid derivatives of the general formula I ##STR1## in which X denotes --O-- or --NH--;R.sup.1 denotes hydrogen, the group --CH.sub.2 --CO--R.sup.3 or the group --CO--CH.sub.2 --NH.sub.2 ;R.sup.2 denotes hydrogen, (C.sub.1 -C.sub.4)-alkyl or the radical R.sup.1 andR.sup.3 denotes (C.sub.1 -C.sub.4)-alkoxy, hydroxyl or amino, it not being possible for both R.sup.1 and R.sup.2 to represent hydrogen when X denotes O,as well as the pharmaceutically tolerated salts thereof, process for the preparation thereof, the use thereof, and pharmaceuticals containing these and the preparation thereof.Type: GrantFiled: March 14, 1990Date of Patent: May 14, 1991Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Ursula Schindler, Bernd Jablonka, Jeffery Troke
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Patent number: 5006540Abstract: Substituted 3-aminosydnonimines of the formula I ##STR1## and their pharmacologically acceptable acid addition salts, wherein R.sup.1 denotes, for example, alkyl having 1 to 8 C atoms, R.sup.2 denotes hydrogen or the radical --COR.sup.3 and R.sup.3 denotes, for example, an aliphatic radical having 1 to 4 C atoms, are prepared, for example, by cyclization of a compound of the formula II ##STR2## and if appropriate subsequent acylation and have useful pharmacological properties.Type: GrantFiled: October 17, 1989Date of Patent: April 9, 1991Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Melitta Just, Helmut Bohn, Jorg Ostrowski
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Patent number: 4987134Abstract: The present invention relates to thienylpiperazines of the general formula I ##STR1## in which R.sup.1 denotes hydrogen or double-bonded oxygen and R.sup.2 denotes hydrogen or double-bonded oxygen, with R.sup.1 and R.sup.2 not both having the same meaning, as well as the pharmaceutically tolerated salts thereof, process for the preparation thereof, the use thereof, and pharmaceuticals containing these and the preparation thereof.Type: GrantFiled: March 16, 1990Date of Patent: January 22, 1991Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Ursula Schindler, Bernd Jablonka, Jeffery Troke
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Patent number: 4966901Abstract: Pyrrole derivatives of the general formula I ##STR1## wherein R denotes alkyl which is substituted by --NH.sub.2 or acylamino, R.sup.1 and R.sup.2 independently of one another denote hydrogen or alkyl having 1 to 4 carbon atoms, R.sup.3 denotes hydrogen, alkyl having 1 to 4 carbon atoms or a carboxylic acid grouping, R.sup.Type: GrantFiled: May 23, 1989Date of Patent: October 30, 1990Assignee: Cassella AktiengesellschaftInventors: Gerhard Zoller, Rudi Beyerle, Ursula Schindler
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Patent number: 4937244Abstract: Substituted 3-aminosydnonimines of the formula I ##STR1## and their pharmacologically acceptable acid addition salts wherein A denotes, for example, --CH.sub.2 --,R.sup.1 denotes hydrogen or the radical --COR.sup.7,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 denote alkyl with 1 to 4 C atoms andR.sup.7 denotes, for example, an aliphatic radical and 1 to 4 C atoms, are prepared by cyclization of a compound of the formula II ##STR2## and if appropriate subsequent acylation and have useful pharmacological properties. The invention includes pharmaceutical preparations containing the present compounds, and the use thereof for treating patients having cardiovascular ailments.Type: GrantFiled: August 3, 1988Date of Patent: June 26, 1990Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle
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Patent number: 4937241Abstract: Pharmacologically useful N-substituted-N-nitrosoaminoacetonitriles of the general formula I ##STR1## wherein A denotes the radical --CH.sub.2 --, --O--, --S(O.sub.n)--, --N(R.sup.2)-- or a direct bond,R.sup.1 and R.sup.Type: GrantFiled: December 27, 1988Date of Patent: June 26, 1990Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Helmut Bohn
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Patent number: 4898866Abstract: 3-(Thien-2-yl)-piperazin-2-ones, substituted in the 3-position, of the general formula ##STR1## wherein R dentoes, for example, phenyl or (C.sub.1 -C.sub.6)-alkyl and R.sup.1 denotes 2-thienyl and pharmacologically tolerable acid addition salts thereof, which possess valuable nootropic properties. The invention also includes methods for making such compounds, formulations containing such compounds and methods for treating a host in need thereof.Type: GrantFiled: May 9, 1989Date of Patent: February 6, 1990Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Ursula Schindler
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Patent number: 4845091Abstract: Optically active substituted 3-aminosydnonimines of the general formula I ##STR1## and their pharmacologically acceptable acid addition salts, wherein R.sup.1 denotes, for example, the radical R.sup.3 (R.sup.4)N-,R.sup.2 denotes the radical 1-methoxyethyl (--CH(CH.sub.3)OCH.sub.3), acetoxy-phenyl-methyl (--CH(C.sub.6 H.sub.5)O--COCH.sub.3), 1-(ethoxycarbonyl)-ethoxy (--O--CH.sub.3)CO.sub.2 C.sub.2 H.sub.5),R.sup.3 denotes alkyl(C.sub.1 -C.sub.4) andR.sup.4 denotes for example alkyl(C.sub.1 -C.sub.4),possess valuable pharmaceutical properties.Type: GrantFiled: July 14, 1986Date of Patent: July 4, 1989Assignee: Cassella AktiengesellschaftInventors: Karl Schonafinger, Rudi Beyerle, Helmut Bohn, Melitta Just, Piero Martorana, Rolf-Eberhard Nitz
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Patent number: 4837225Abstract: 2,5-Dimethylpyrrole derivatives of the formula I ##STR1## in which R denotes alkyl which is substituted by --NH.sub.2, acylamino of the formula--NH--CX--R.sup.1or by an optionally substituted heterocycle having 1 hetero member; or denotes an optionally substituted heterocycle having 1 member, and X and R.sup.1 have the meanings givenand their pharmacologically acceptable acid addition salts, their preparation by reaction of amines of the formula IIR--NH.sub.2 (II)with acetonylacetone or by acylating N-aminoalkyl-2,5-dimethylpyrroles, and their use as pharmaceutical active compounds.Type: GrantFiled: July 17, 1986Date of Patent: June 6, 1989Assignee: Cassell AktiengesellschaftInventors: Gerhard Zoller, Rudi Beyerle, Ursula Schindler, Rolf-Eberhard Nitz, Piero Martorana
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Patent number: 4816454Abstract: Substituted 4,5-dihydro-3(2H)-pyridazinones of the formula I ##STR1## wherein R, for example, denotes a radical of the formula ##STR2## R.sup.1 and R.sup.2, for example, denote hydrogen or methyl, R.sup.3, for example, denotes 2-methoxy-ethoxy, 3-pyridyl-methoxy, amino-carbonyl-methoxy, hydroxy-carbonyl-methoxy, methyl-thio, (2-methoxy-ethyl)-amino-carbonyl-methoxy, 3-pyridyl-methyl or 5-methyl-1,3,4-oxadiazol-2-yl and R.sup.4, for example, denotes hydrogen, have useful pharmacological properties and can therefore be used for the preparation of pharmacological products.Type: GrantFiled: September 12, 1985Date of Patent: March 28, 1989Assignee: Cassella AktiengesellschaftInventors: Gerhard Zoller, Rudi Beyerle, Melitta Just, Helmut Bohn, Piero Martorana, Rolf-Eberhard Nitz
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Patent number: 4785010Abstract: 2-(Aminoalkyl)-pyrrole derivatives of the formula ##STR1## wherein R denotes hydrogen, alkyl or phenyl, R.sup.1 denotes, for example, hydrogen, alkyl, alkoxy-carbonyl, aryl, substituted aryl or heteroaryl, R.sup.2 and R.sup.3 denote, for example, hydrogen, alkyl, alkanoyl, arylcarbonyl, heteroarylcarbonyl or arylenedicarbonyl and n denotes 1, 2 or 3, and their acid addition salts, are used as pharmacological active compounds for combating cerebral aging processes.Type: GrantFiled: November 12, 1985Date of Patent: November 15, 1988Assignee: Cassella AktiengesellschaftInventors: Gerhard Zoller, Rudi Beyerle, Ursula Schindler, Rolf-Eberhard Nitz, Piero A. Martorana
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Patent number: 4666902Abstract: Tetrahydropyridazinones of the formula I ##STR1## wherein R denotes an optionally substituted carbocyclic or heterocyclic radical, R.sup.1 denotes hydrogen; alkyl; aralkyl, which is optionally substituted in the aryl part; or acyl, and R.sup.2 denotes hydrogen; alkyl, which can optionally be substituted; or optionally substituted phenyl; and their acid addition compounds, if these can be prepared.The tetrahydropyridazinone derivatives of the formula I according to the invention and their physiologically acceptable salts exhibit useful pharmacological actions.Type: GrantFiled: June 8, 1984Date of Patent: May 19, 1987Assignee: Cassella AktiengesellschaftInventors: Gerhard Zoller, Rudi Beyerle, Melitta Just, Piero Martorana, Helmut Bohn, Rolf-Eberhard Nitz