Patents by Inventor Rudolf Verrijk

Rudolf Verrijk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing polymer microparticles
    Patent number: 8846035
    Abstract: The present invention describes methods and tools for preparing a population of monodisperse polymer microparticles, which are of particular interest in the field of drug delivery.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: September 30, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Marcel Rene Bohmer, Johannes Antonius Maria Steenbakkers, Suzanna Helena Petronella Maria De Winter, Anne Bechet, Rudolf Verrijk
  • Controlled release interferon drug products and treatment of HCV infections using same
    Patent number: 8137661
    Abstract: The invention relates to controlled release formulations comprising a microparticle comprising a biodegradable polymer and one or more interferon compounds and methods of using the formulations.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: March 20, 2012
    Assignee: Biolex Therapeutics, Inc.
    Inventors: David Gelvin Spencer, Jr., John Elliott Humphries, Leonardus Gerardus Jozef De Leede, Rudolf Verrijk
  • METHODS FOR PREPARING POLYMER MICROPARTICLES
    Publication number: 20100209525
    Abstract: The present invention describes methods and tools for preparing a population of monodisperse polymer microparticles, which are of particular interest in the field of drug delivery.
    Type: Application
    Filed: October 21, 2008
    Publication date: August 19, 2010
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Marcel Rene Bohmer, Johannes Antonius Maria Steenbakkers, Suzanna Helena Petronella Maria De Winter, Anne Bechet, Rudolf Verrijk
  • Controlled Release Interferon Drug Products and Treatment of HCV Infections Using Same
    Publication number: 20090068280
    Abstract: The invention relates to controlled release formulations comprising a microparticle comprising a biodegradable polymer and one or more interferon compounds and methods of using the formulations.
    Type: Application
    Filed: July 25, 2008
    Publication date: March 12, 2009
    Inventors: David Gelvin SPENCER, JR., John Elliott HUMPHRIES, Leonardus Gerardus Jozef DE LEEDE, Rudolf VERRIJK
  • Method for the preparation of purified microparticles
    Patent number: 7468151
    Abstract: The present invention is directed to a method for purifying microparticles. These microparticles are prepared in a liquid medium and are recovered free from impurities and undesirable reaction products in a particular way. In addition, an apparatus has been claimed to carry out the method of the invention. Since the microparticles are essentially intended to carry drugs or other biologically active compounds, the entire process can be carried out aseptically.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: December 23, 2008
    Assignee: Octoplus Sciences B.V.
    Inventors: Adrianus Franciscus G. van Buitenen, Rudolf Verrijk
  • Hydrogel Microspheres with Improved Release Profile
    Publication number: 20080241267
    Abstract: The invention provides an emulsion-based method for the preparation of controlled release microspheres for the delivery of active compounds. The method comprises the preparation of an emulsion comprising an aqueous dispersed phase which comprises a polymer capable of forming a hydrogel, a bioactive protein, and water, and which is substantially free from insoluble aggregates of the bioactive protein. Subsequently, the polymer physically or chemically crosslinked to form a hydrogel. The invention further provides active protein-loaded hydrogel microspheres which are prepared by the process, and which are substantially free from insoluble aggregates of the active protein. The microspheres exhibit controlled release, with release profiles which are considerably improved over those of previously known hydrogel microspheres. The microspheres may be used to deliver therapeutic or diagnostic proteins by injection.
    Type: Application
    Filed: March 18, 2005
    Publication date: October 2, 2008
    Inventor: Rudolf Verrijk
  • Colloidal drug carrier system
    Publication number: 20050238716
    Abstract: The present invention relates to a drug carrier system comprising a plurality of colloidal particles having a core and a shell, said particles being comprised of copolymer molecules, which copolymer comprises at least one A block and at least one B block different from the at least one A block, wherein the at least one A block consists of a polymer unit of a first set of monomers and the at least one B block consists of a second set of monomers. In addition, the invention relates to block copolymers that are useful in this system, as well as pharmaceutical compositions based on said colloidal system.
    Type: Application
    Filed: August 28, 2003
    Publication date: October 27, 2005
    Inventors: Rudolf Verrijk, Delphine Ramos, Okke Franssen
  • Method for the preparation of purified microparticles
    Publication number: 20050084536
    Abstract: The present invention is directed to a method for purifying microparticles. These microparticles are prepared in a liquid medium and are recovered free from impurities and undesirable reaction products in a particular way. In addition, an apparatus has been claimed to carry out the method of the invention. Since the microparticles are essentially intended to carry drugs or other biologically active compounds, the entire process can be carried out aseptically.
    Type: Application
    Filed: October 23, 2002
    Publication date: April 21, 2005
    Inventors: Adrianus Van Buitenen, Rudolf Verrijk