Patents by Inventor Russell D. Lewis

Russell D. Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10927355
    Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: February 23, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold
  • Publication number: 20180371430
    Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.
    Type: Application
    Filed: September 5, 2018
    Publication date: December 27, 2018
    Applicant: California Institute of Technology
    Inventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold
  • Patent number: 10093906
    Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: October 9, 2018
    Assignee: California Institute of Technology
    Inventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold
  • Publication number: 20180148745
    Abstract: The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 31, 2018
    Applicants: California Institute of Technology, Provivi, Inc.
    Inventors: Francis H. Arnold, Hans Renata, John A. McIntosh, Russell D. Lewis, Sek Bik Jennifer Kan, Kari Hernandez, Pedro Coelho, David Rozzell, Chen Zhang
  • Publication number: 20170218346
    Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 3, 2017
    Applicant: California Institute of Technology
    Inventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold