Patents by Inventor Russell L. Barton

Russell L. Barton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody drug-conjugates
    Patent number: 5665358
    Abstract: Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Russell L. Barton, Deborah L. Guttman-Carlisle, Gary A. Koppel
  • Antibody-drug conjugates
    Patent number: 5643573
    Abstract: Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Russell L. Barton, Deborah L. Guttman-Carlisle, Gary A. Koppel
  • Antibody-drug conjugates
    Patent number: 5556623
    Abstract: Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: September 17, 1996
    Assignee: Eli Lilly and Company
    Inventors: Russell L. Barton, Deborah L. Guttman-Carlisle, Gary A. Koppel
  • Antibody-drug conjugates
    Patent number: 5514794
    Abstract: Derivatized drugs are prepared with a linker consisting of a malonate, wherein the drug is linked through a methylene to the 2-position carbon of the malonate.
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: May 7, 1996
    Assignee: Eli Lilly and Company
    Inventor: Russell L. Barton
  • Antibody-drug conjugates
    Patent number: 5010176
    Abstract: Modified antibodies or antigen-recognizing fragments are prepared with a linker consisting of a malonate, wherein the antibody or fragment thereof is attached through a carbonyl to an ester or amide group on one of the malonate carboxyls, and the drug is linked through a methylene to the 2-position carbon of the malonate.
    Type: Grant
    Filed: November 10, 1988
    Date of Patent: April 23, 1991
    Assignee: Eli Lilly and Company
    Inventor: Russell L. Barton
  • Ascorbic acid ethers in angiogene
    Patent number: 4552888
    Abstract: Ethers of ascorbic and isoascorbic acid and ketals and acetals thereof, angiogenesis inhibitors.
    Type: Grant
    Filed: September 28, 1983
    Date of Patent: November 12, 1985
    Assignee: Eli Lilly and Company
    Inventors: Gary A. Koppel, Russell L. Barton, Jesse R. Bewley, Stephen L. Briggs, Joseph W. Parton
  • Furo[3,2-b]furan-2-(3H)-ones
    Patent number: 4552895
    Abstract: The invention provides for certain compounds derived from ascorbic acid and their formulations which are useful in inhibiting angiogenesis in mammals.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: November 12, 1985
    Assignee: Eli Lilly and Company
    Inventors: Gary A. Koppel, Russell L. Barton, Stephen L. Briggs
  • Process for recovering 2-acetylthiomethyl-5-aminopentanoic acid
    Patent number: 4537727
    Abstract: A process is described for recovering 2-acetylthiomethyl-5-aminopentanoic acid from an impure acid addition salt thereof by treating the latter in a polar organic solvent with a base.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventors: Russell L. Barton, Stephen L. Briggs, Gary A. Koppel
  • Process for preparing 2-acetylthiomethyl-5-guanidinopentanoic acid
    Patent number: 4501703
    Abstract: A process is described for preparing 2-acetylthiomethyl-5-quanidinopentanoic acid by treating 2-acetylthiomethyl-5-aminopentanoic acid with 1-quanyl-3,5-dimethylpyrazole in a medium comprising a hydroxylated solvent.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Russell L. Barton, Stephen L. Briggs, Gary A. Koppel