Patents by Inventor Russell Morrison Gordley

Russell Morrison Gordley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC RECEPTORS AND METHODS OF USE THEREOF
    Publication number: 20240277765
    Abstract: Provided herein are acute myeloid leukemia antigen targets for chimeric receptors and methods of using same.
    Type: Application
    Filed: November 3, 2023
    Publication date: August 22, 2024
    Inventors: Brian Scott Garrison, Jennifer Chien, Kathryn Armstrong Loving, Russell Morrison Gordley, Michelle Elizabeth Hung
  • ARMED CHIMERIC RECEPTORS AND METHODS OF USE THEREOF
    Publication number: 20240277766
    Abstract: Described herein are immunoresponsive cells engineered to express cytokines, chimeric receptors, and synthetic transcription factor systems. Also described herein are nucleic acids, cells, and methods directed to the same.
    Type: Application
    Filed: December 15, 2023
    Publication date: August 22, 2024
    Inventors: Marcela GUZMAN AYALA, Russell Morrison GORDLEY, Michelle Elizabeth HUNG, Gary LEE, Timothy Kuan-Ta LU
  • ERT2 MUTANTS AND USES THEREOF
    Publication number: 20240226296
    Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
    Type: Application
    Filed: October 5, 2023
    Publication date: July 11, 2024
    Inventors: Michelle Elizabeth Hung, Rebecca Tayler Cottman, Russell Morrison Gordley, Gary Lee, Timothy Kuan-Ta Lu, Srinivasaraghavan Kannan, Chandra Shekhar Verma
  • Chimeric receptors and methods of use thereof
    Patent number: 12005081
    Abstract: Provided herein are acute myeloid leukemia antigen targets for chimeric receptors and methods of using same.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: June 11, 2024
    Assignee: Senti Biosciences, Inc.
    Inventors: Brian Scott Garrison, Jennifer Chien, Kathryn Armstrong Loving, Russell Morrison Gordley, Michelle Elizabeth Hung
  • DRUG-REGULATABLE TRANSCRIPTION FACTORS
    Publication number: 20240182910
    Abstract: Provided herein are synthetic inducible transcription factors that can be activated by a cognate ligand (e.g., caffeine, a cannabinoid, nicotine, rapamycin, or mifepristone) and isolated cells expressing the inducible transcription factors. Also provided are methods of modulating transcription of a gene of interest using an inducible transcription factor.
    Type: Application
    Filed: October 18, 2023
    Publication date: June 6, 2024
    Inventors: Michelle Elizabeth Hung, Russell Morrison Gordley
  • ERT2 MUTANTS AND USES THEREOF
    Publication number: 20240150433
    Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 9, 2024
    Inventors: Michelle Elizabeth Hung, Rebecca Tayler Cottman, Russell Morrison Gordley, Gary Lee, Timothy Kuan-Ta Lu, Srinivasaraghavan Kannan, Chandra Shekhar Verma
  • DRUG-REGULATABLE TRANSCRIPTIONAL REPRESSORS
    Publication number: 20240141364
    Abstract: Provided herein are chimeric polypeptides for drug-regulated transcriptional repression. Also provided are methods of inhibiting repression of a gene of interest.
    Type: Application
    Filed: October 6, 2023
    Publication date: May 2, 2024
    Inventors: Michelle Elizabeth Hung, Rebecca Tayler Cottman, Russell Morrison Gordley
  • ERT2 MUTANTS AND USES THEREOF
    Publication number: 20240131159
    Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
    Type: Application
    Filed: October 4, 2023
    Publication date: April 25, 2024
    Inventors: Michelle Elizabeth Hung, Rebecca Tayler Cottman, Russell Morrison Gordley, Gary Lee, Timothy Kuan-Ta Lu, Srinivasaraghavan Kannan, Chandra Shekhar Verma
  • SECRETABLE PAYLOAD REGULATION
    Publication number: 20240091358
    Abstract: Described herein are chimeric proteins including membrane-cleavable chimeric proteins and degron-fusion chimeric proteins. Also described herein are nucleic acids, pharmaceutical compositions, methods, and methods of treatment directed to the same.
    Type: Application
    Filed: July 13, 2023
    Publication date: March 21, 2024
    Inventors: Michelle Elizabeth HUNG, Russell Morrison GORDLEY
  • PROTEIN PAYLOAD RELEASE
    Publication number: 20240082303
    Abstract: Described herein are chimeric proteins, specifically membrane-cleavable chimeric systems. Also described herein are nucleic acids, cells, and methods directed to the same.
    Type: Application
    Filed: May 4, 2023
    Publication date: March 14, 2024
    Inventors: Michelle Elizabeth HUNG, Russell Morrison GORDLEY, Gary LEE
  • INDUCIBLE CELL DEATH SYSTEMS
    Publication number: 20230405144
    Abstract: Provided herein are compositions and methods for inducing cell death in a regulated manner, for example in a safety switch system. Inducible cell death can be triggered by ligand binding to a one or more ligand binding domains. Cell death can include induction of apoptosis.
    Type: Application
    Filed: May 18, 2023
    Publication date: December 21, 2023
    Inventors: Rocky CHEUNG, Russell Morrison GORDLEY, Timothy Kuan-Ta LU, Michelle Elizabeth HUNG, Rebecca Tayler COTTMAN
  • INHIBITORY CHIMERIC RECEPTOR ARCHITECTURES
    Publication number: 20230272037
    Abstract: Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.
    Type: Application
    Filed: August 18, 2022
    Publication date: August 31, 2023
    Inventors: Russell Morrison Gordley, Marcela Guzman Ayala, Gary Lee, Nicholas Frankel
  • COMBINATORIAL CANCER IMMUNOTHERAPY
    Publication number: 20230270789
    Abstract: Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
    Type: Application
    Filed: July 25, 2022
    Publication date: August 31, 2023
    Inventors: Timothy Kuan-Ta Lu, Russell Morrison Gordley, Jack Tzu-Chiao Lin, Brian Scott Garrison, Philip Janmin Lee, Alba Gonzalez-Junca, Don-Hong Wang
  • INHIBITORY CHIMERIC RECEPTOR ARCHITECTURES
    Publication number: 20230235051
    Abstract: Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.
    Type: Application
    Filed: August 17, 2022
    Publication date: July 27, 2023
    Inventors: Wilson Wong, Seunghee Lee, Russell Morrison Gordley, Marcela Guzman Ayala, Gary Lee, Nicholas Frankel, Xi Kang
  • METHOD AND COMPOSITIONS FOR REGULATED ARMORING OF CELLS
    Publication number: 20230011052
    Abstract: Provided herein are compositions and methods for regulating expression of effector molecules using regulatable transcription factors and/or activation inducible promoters.
    Type: Application
    Filed: June 10, 2022
    Publication date: January 12, 2023
    Inventors: Marcela Guzman Ayala, Russell Morrison Gordley, Michelle Elizabeth Hung, Gary Lee, Jack Tzu-Chiao Lin, Timothy Kuan-Ta Lu, Assen Boyanov Roguev
  • CHIMERIC RECEPTOR SENSORS
    Publication number: 20220396609
    Abstract: Provided herein are generalized extracellular molecule sensors (GEMSs) and polynucleotides encoding the GEMSs. Also provided herein are methods of making and using the GEMSs, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 15, 2022
    Inventors: Russell Morrison Gordley, Daniel Frimannsson, Michelle Elizabeth Hung
  • COMBINATORIAL CANCER IMMUNOTHERAPY
    Publication number: 20220378822
    Abstract: Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
    Type: Application
    Filed: August 28, 2020
    Publication date: December 1, 2022
    Inventors: Timothy Kuan-Ta Lu, Russell Morrison Gordley, Jack Tzu-Chiao Lin, Brian Scott Garrison, Philip Janmin Lee, Alba Gonzalez-Junca, Don-Hong Wang
  • COMBINATORIAL CANCER IMMUNOTHERAPY
    Publication number: 20220378842
    Abstract: Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
    Type: Application
    Filed: June 23, 2022
    Publication date: December 1, 2022
    Inventors: Timothy Kuan-Ta Lu, Russell Morrison Gordley, Jack Tzu-Chiao Lin, Brian Scott Garrison, Philip Janmin Lee, Alba Gonzalez-Junca, Don-Hong Wang, Daniel Frimannsson
  • Combinatorial cancer immunotherapy
    Patent number: 11446332
    Abstract: Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: September 20, 2022
    Assignee: SENTI BIOSCIENCES, INC.
    Inventors: Timothy Kuan-Ta Lu, Russell Morrison Gordley, Jack Tzu-Chiao Lin, Brian Scott Garrison, Philip Janmin Lee, Alba Gonzalez-Junca, Don-Hong Wang
  • CHIMERIC INHIBITORY RECEPTOR
    Publication number: 20220289842
    Abstract: Provided herein are chimeric inhibitory receptor constructs and compositions, and cells comprising the same. Also provided are methods of using chimeric inhibitory receptor constructs and compositions, and cells comprising the same.
    Type: Application
    Filed: August 20, 2020
    Publication date: September 15, 2022
    Inventors: Russell Morrison Gordley, Nicholas Frankel