Abstract: The present application provides materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing progenitor cells that are genetically modified via genome editing to increase the production of fetal hemoglobin (HbF), as well as modified progenitor cells (including, for example, CD34+ human hematopoietic stem cells) producing increased levels of HbF, and methods of using such cells for treating hemoglobinopathies such as sickle cell anemia and ?-thalassemia.

Abstract: The present application provides materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing progenitor cells that are genetically modified via genome editing to increase the production of fetal hemoglobin (HbF), as well as modified progenitor cells (including, for example, CD34+ human hematopoietic stem cells) producing increased levels of HbF, and methods of using such cells for treating hemoglobinopathies such as sickle cell anemia and ?-thalassemia.

Abstract: An occupancy monitoring device, such as for a bed or chair, including a capacitor having a first electrode adapted for attachment along the side of a bed or mattress or a chair, a second electrode adapted for positioning remotely from the first electrode and a defector tor detecting dielectric shift induced in the capacitor by movement of an occupant on the bed, mattress or chair.

Abstract: The important feature of this invention is the independent adjustable drawstrings that run through independent drawstring chambers that surround the entire circumference of each bra cup. The Drawstring Bra Cups are designed to offer the moderate-to-large breasted and overly heavy breasted females better support and the illusion of smaller breast. However, it is also suitable for the smaller breasted females seeking the illusion of fuller breast size. Our bra is also excellent for females with sagging breast due to childbirth, aging and weight changes and females involved in sports activities, exercising, and just normal everyday usage. The drawstrings can be tighten or pulled up to individual preferred size, shape, comfort, and support. The physical appearance of this bra is that of a conventional brassiere. The drawstring alleviates some of stress put on the bra straps, which in turn help, eliminate much of the bruising on the shoulders.