Abstract: A resin tube connection device includes a resin tube, a resin expanding portion and a metal sleeve. The resin expanding portion has a sealing surface being able to come into contact with a contact surface. Further, the resin expanding portion has a second flow path that communicates with a first flow path of the resin tube and opens in the sealing surface. The sealing surface projects farther than an end surface of the metal sleeve in an axial direction. The maximum length of a contact region where the resin expanding portion and the metal sleeve come into contact with each other in the axial direction in an outer surface is larger than the thickness of a resin layer in a radial direction.

Abstract: A bioinert pipe includes a flow path inside, an inner wall of the flow path is composed of a resin tube and an outer peripheral surface of the resin tube is covered with a metal tube. The bioinert pipe includes an end portion extension member attached to an end portion of the metal tube, and the end portion extension member is made from a material harder than the resin tube and has a first surface and a second surface. The first surface is facing and in contact with an end surface of the metal tube and the second surface is directed opposite to the first surface. a through hole having an inner diameter substantially the same as an inner diameter of the metal tube is provided so as to pass from the first surface to the second surface in the end portion extension member. An edge of the through hole on the second surface of the end portion extension member has a chamfered shape, and the resin tube is inserted into the through hole.

Abstract: A resin tube is prepared. Further, a formation tool having a pressing surface and a projection that projects from the pressing surface and is insertable into the resin tube is prepared. The projection of the formation tool is inserted from an end of the resin tube into the resin tube. The pressing surface of the formation tool is pressed against an end surface of the resin tube. Thermal energy is applied to the end of the resin tube, whereby a shape of the pressing surface of the formation tool is transferred to the end surface of the resin tube, and the end of the resin tube is formed into a flange shape.