Patents by Inventor Ryota Yoshimoto
Ryota Yoshimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11073199Abstract: A breather device that communicates an inside of a case with an outside of the case in a vertical direction includes a cylindrical body having a hollow portion that extends in the vertical direction, a stopper inserted in the hollow portion, and a blocking body that is located in a space defined by the stopper in the hollow portion, and blocks a communicating hole provided in a lower part of the cylindrical body as viewed in the vertical direction. The communicating hole ceases to be blocked when the pressure inside the case exceeds a first predetermined value, and the blocking body moves upward in the vertical direction in the space.Type: GrantFiled: July 15, 2020Date of Patent: July 27, 2021Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, AISIN AW CO., LTD.Inventors: Guodong Tan, Shinichi Ito, Yukihiko Ideshio, Masashi Ikemura, Takashi Iijima, Masamichi Yamaguchi, Keisuke Tanaka, Tetsuya Yamaguchi, Ryota Yoshimoto
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Publication number: 20210018088Abstract: An oil supply system for a vehicle includes a plurality of oil pumps, suction oil passages, and a communication passage. The oil pumps are independently operational. The suction oil passages each connect an associated one of suction portions of the plurality of oil pumps and a common oil strainer. The communication passage connects the suction oil passages.Type: ApplicationFiled: July 13, 2020Publication date: January 21, 2021Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, AISIN AW CO., LTD.Inventors: Guodong TAN, Shinichi ITO, Yukihiko IDESHIO, Masashi IKEMURA, Ryota YOSHIMOTO, Shinichiro MATSUBARA, Masamichi YAMAGUCHI, Takashi IIJIMA
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Publication number: 20210018085Abstract: A breather device that communicates an inside of a case with an outside of the case in a vertical direction includes a cylindrical body having a hollow portion that extends in the vertical direction, a stopper inserted in the hollow portion, and a blocking body that is located in a space defined by the stopper in the hollow portion, and blocks a communicating hole provided in a lower part of the cylindrical body as viewed in the vertical direction. The communicating hole ceases to be blocked when the pressure inside the case exceeds a first predetermined value, and the blocking body moves upward in the vertical direction in the space.Type: ApplicationFiled: July 15, 2020Publication date: January 21, 2021Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, AISIN AW CO., LTD.Inventors: Guodong TAN, Shinichi ITO, Yukihiko IDESHIO, Masashi IKEMURA, Takashi IIJIMA, Masamichi YAMAGUCHI, Keisuke TANAKA, Tetsuya YAMAGUCHI, Ryota YOSHIMOTO
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Patent number: 6793920Abstract: A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.Type: GrantFiled: August 8, 2001Date of Patent: September 21, 2004Assignee: Ajinomoto Co., Inc.Inventors: Mitsuyo Nagano, Hiroshi Yamamoto, Morikazu Kito, Ryota Yoshimoto, Tsuyoshi Kobayashi
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Publication number: 20040063701Abstract: The present invention relates to a novel serotonin antagonist and an anti-platelet agent, more particularly, a serotonin antagonist and an anti-platelet agent which potently and specifically inhibit the serotonin 2 receptor with low adverse side effect.Type: ApplicationFiled: September 10, 2003Publication date: April 1, 2004Applicant: AJINOMOTO CO., INCInventors: Shingo Makino, Harumi Arisaka, Hiroshi Yamamoto, Masataka Shoji, Ryota Yoshimoto
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Patent number: 6476049Abstract: A compound 1-formyl-N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl)) ethyl isonipecotic acid amide or an analog thereof or a pharmaceutically acceptable salt thereof provides a therapeutic agent for treating a patient suffering from intermittent claudication.Type: GrantFiled: August 22, 2001Date of Patent: November 5, 2002Assignee: Ajinomoto Co., Inc.Inventors: Takashi Komiyama, Hideaki Kihara, Ken Hirose, Hiroshi Sigematsu, Ryota Yoshimoto
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Publication number: 20020147195Abstract: The present invention relates to a novel serotonin antagonist and an anti-platelet agent, more particularly, a serotonin antagonist and an anti-platelet agent which potently and specifically inhibit the serotonin 2 receptor with low adverse side effect.Type: ApplicationFiled: March 21, 2002Publication date: October 10, 2002Applicant: AJINOMOTO CO., INC.Inventors: Shingo Makino, Harumi Arisaka, Hiroshi Yamamoto, Masataka Shoji, Ryota Yoshimoto
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Publication number: 20020037906Abstract: A compound 1-formyl-N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl)) ethyl isonipecotic acid amide or an analog thereof or a pharmaceutically acceptable salt thereof provides a therapeutic agent for treating a patient suffering from intermittent claudication.Type: ApplicationFiled: August 22, 2001Publication date: March 28, 2002Applicant: AJINOMOTO CO., INC.Inventors: Takashi Komiyama, Hideaki Kihara, Ken Hirose, Hiroshi Sigematsu, Ryota Yoshimoto
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Publication number: 20020028204Abstract: A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.Type: ApplicationFiled: August 8, 2001Publication date: March 7, 2002Applicant: Ajinomoto Co., Inc.Inventors: Mitsuyo Nagano, Hiroshi Yamamoto, Morikazu Kito, Ryota Yoshimoto, Tsuyoshi Kobayashi
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Publication number: 20020019533Abstract: The present invention relates to a novel serotonin antagonist and an anti-platelet agent, more particularly, a serotonin antagonist and an anti-platelet agent which potently and specifically inhibit the serotonin 2 receptor with low adverse side effect.Type: ApplicationFiled: February 8, 1999Publication date: February 14, 2002Inventors: SHINGO MAKINO, HARUMI ARISAKA, HIROSHI YAMAMOTO, MASATAKA SHOJI, RYOTA YOSHIMOTO
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Patent number: 6303635Abstract: A thrombolytic drug containing cyproheptadine, a compound of the following formula or a salt thereof as the active ingredient is provided. This thrombolytic drug has a function of accelerating the release of a tissue plasminogen activator (t-PA), while exerting no effect on the release of type-1 plasminogen activator inhibitor (PAI-1) which deactivates t-PA or reducing the release thereof. wherein n represents an integer of 2 or 3, Y represents a hydrogen atom or halogen atom, and X represents a formyl group, acetyl group or hydrogen atom.Type: GrantFiled: August 27, 1999Date of Patent: October 16, 2001Assignee: Ajinomoto Co., Inc.Inventors: Yohko Kawai, Kiyoaki Watanabe, Hideaki Kihara, Hiroshi Yamamoto, Ryota Yoshimoto
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Patent number: 6280731Abstract: A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.Type: GrantFiled: April 26, 1999Date of Patent: August 28, 2001Assignee: Ajinomoto Co., Inc.Inventors: Mitsuyo Nagano, Hiroshi Yamamoto, Morikazu Kito, Ryota Yoshimoto, Tsuyoshi Kobayashi
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Patent number: 6262076Abstract: Disclosed is a pharmaceutical composition for use in the treatment of diabetic neuropathy, which comprises a piperidine derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an effective ingredient: wherein n is an integer of 2 of 3, Y is a hydrogen atom or halogen atom, and X is a formyl group, acetyl group or hydrogen atom.Type: GrantFiled: January 28, 2000Date of Patent: July 17, 2001Assignee: Ajinomoto Co., Inc.Inventors: Norman E. Cameron, Hideaki Kihara, Ryota Yoshimoto
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Patent number: 5932593Abstract: The present invention also relates to a method of using these novel materials, and other materials, to treat or prevent a disease caused by serotonin or a method of treating or preventing platelet aggregation. The compounds used are piperidine derivatives having the formula (I): ##STR1## wherein the various substituents are defined below.Type: GrantFiled: August 25, 1997Date of Patent: August 3, 1999Assignee: Ajinomoto Co., Ltd.Inventors: Shingo Makino, Harumi Arisaka, Hiroshi Yamamoto, Masataka Shoji, Ryota Yoshimoto
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Patent number: 5916805Abstract: A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.Type: GrantFiled: June 27, 1997Date of Patent: June 29, 1999Assignee: Ajinomoto Co., Inc.Inventors: Mitsuyo Nagano, Hiroshi Yamamoto, Morikazu Kito, Ryota Yoshimoto, Tsuyoshi Kobayashi
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Patent number: 5856126Abstract: A multimer peptide from a snake venom has an activity to inhibit binding between von Willebrand factor and platelets. The multimer peptide is used to obtain a single strand peptide which does not substantially cause decrease in platelets at a minimum dose for exhibiting the activity in vivo. The single strand peptide is obtained by allowing the multimer peptide to exist together with a protein-denaturing agent, and glutathione and/or cysteine, and thereby disconnecting disulfide bonds between peptide chains for constituting the multimer peptide while substantially preserving disulfide bonds within the peptide chains. Alternatively, the single strand peptide, a mutant thereof, or a part thereof is produced by genetic engineering techniques by using genes coding for them.Type: GrantFiled: March 20, 1996Date of Patent: January 5, 1999Assignee: Ajinomoto Co., Inc.Inventors: Naoyuki Fukuchi, Hiroshi Yamamoto, Mitsuyo Nagano, Morikazu Kito, Akiko Tanaka, Koichi Ishii, Tsuyoshi Kobayashi, Ryota Yoshimoto
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Patent number: 5250681Abstract: A piperidine compound of the formula (I): ##STR1## wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.dbd.CH--, --C.dbd.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, --N(COOC.sub.2 H.sub.5)--, --N(CHO)--, --N(CH.sub.3)--, --CO--, --SO--, or --SO.sub.2 --; Y is --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CO--, --O--, --S--, --NH--, --OCH.sub.2 --, --SCH.sub.2 --, --NHCH.sub.2 --, --CH(OH)CH.sub.2 -- or --CH(OH)CH(OH)--; and Q is substituted or unsubstituted n-hexyl, carboxypropyl, ethoxycarbonylpropyl, cyanopropyl, cyclohexyl, phenyl, indanyl, naphthyl, tetrahydronaphthyl, benzocycloheptyl, piperidinyl, tetrahydroisoquinolinyl, indolyl, pyrolyl, furyl, thienyl, thiazolyl, oxazolyl or N-methylpyrolyl, wherein any one or more of the --(CH.sub.2)-groups of the hexyl, carboxypropyl, ethoxycarbonylpropyl and cyanopropyl groups may be replaced by --CH.dbd.CH--, --C.dbd.Type: GrantFiled: February 15, 1991Date of Patent: October 5, 1993Assignee: Ajinomoto Co., Inc.Inventors: Masataka Shoji, Kozo Toyota, Chikahiko Eguchi, Ryota Yoshimoto, Yoshikatsu Koyama, Hideki Domoto, Akira Kamimura
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Patent number: 5231105Abstract: An ethylamine derivative of formula (I): ##STR1## wherein A represents a carbon atom or a nitrogen atom;B represents a substituted or unsubstituted aralkyl or aryl group;C represents hydrogen, alkyl, aralkyl, or aryl, each of which may optionally be substituted orC may optionally be bonded to A to form an alkylene bridge which is optionally substituted,Q represents a substituted or unsubstituted aryl group, said group optionally being substituted by hetero atom(s) or substituent(s) optionally containing hetero atom(s); andX represents an alkylene bridge having from 2 to 20 carbon atoms and is optionally substituted with groups which include hetero atoms with the non-hetero atom substituents optionally containing hetero atoms.Type: GrantFiled: May 22, 1989Date of Patent: July 27, 1993Assignee: Ajinomoto Co., Inc.Inventors: Masataka Shoji, Kozo Toyota, Chikahiko Eguchi, Ryota Yoshimoto, Yosikatsu Koyama, Hideki Domoto, Akira Kamimura
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Patent number: 5229400Abstract: A piperidine derivative of general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein ##STR2## is any of several specified aromatic-containing groups; X is selected from one of several hetero atom-containing groups or C.sub.Type: GrantFiled: October 4, 1991Date of Patent: July 20, 1993Assignee: Ajinomoto Co., Inc.Inventors: Akira Hirasawa, Masataka Shoji, Ryota Yoshimoto, Yuichi Gyotoku, Chikahiko Eguchi
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Patent number: RE38257Abstract: A piperidine compound of the formula (I): wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH2)n, which may be substituted, in which n is 0 or an integer of 1 to 10, —CH≡CH—, —C≡C—, —O—, —S—, —NH—, —N(COCH3)—, —N(COOC2H5)—, —N(CHO)—, —N(CH3)—, —CO—, —SO—, or —SO2—; Y is —CH≡CH—, —CH2CH2—, —CH2CO—, —O—, —S—, —NH—, —OCH2—, —SCH2—, —NHCH2—, —CH(OH)CH2— or —CH(OH)CH(OH)—; and Q is substituted or unsubstituted n-hexyl, carboxypropyl, ethoxycarbonylpropyl, cyanopropyl, cyclohexyl, phenyl, indanyl, naphthyl, tetrahydronaphthyl, benzocycloheptyl, piperidinyl, tetrahydroisoquinolinyl, indolyl, pyrolyl, furyl, thienyl, thiazolyl, oxazolyl or N-methylpyrolyl, wherein any one or more of tType: GrantFiled: February 10, 1999Date of Patent: September 23, 2003Assignee: Ajinomoto Co., Inc.Inventors: Masataka Shoji, Kozo Toyota, Chikahiko Eguchi, Ryota Yoshimoto, Yoshikatsu Koyama, Hideki Domoto, Akira Kamimura