Patents by Inventor S. Munir Alam

S. Munir Alam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV-1 ENVELOPE STABILIZING MUTATIONS
    Publication number: 20210379177
    Abstract: The technology is directed to HIV envelopes which comprise sequence modifications wherein these modifications prevent CD4-induced transitions of the HIV envelope. Specifically, the disclosure provides recombinant HIV-1 Env proteins comprising mutations, wherein the envelope is a protomer, and wherein three protomers form a trimer stabilized by the presence of the mutations. Provided also are compositions comprising envelopes of the technology, and methods of use.
    Type: Application
    Filed: September 5, 2019
    Publication date: December 9, 2021
    Inventors: Rory HENDERSON, S. Munir ALAM, Barton F. HAYNES, Kevin J. WIEHE
  • Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies
    Patent number: 10588960
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: March 17, 2020
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • MPER-liposome conjugates and uses thereof
    Patent number: 10076567
    Abstract: The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: September 18, 2018
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Bette T. Korber, S. Munir Alam
  • LIPOSOME-PEPTIDE CONJUGATE AND METHOD OF USING SAME TO INDUCE PRODUCTION OF ANTI-HIV ANTIBODIES
    Publication number: 20180161423
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: June 26, 2017
    Publication date: June 14, 2018
    Inventors: Barton F. HAYNES, S. Munir ALAM, Hua-Xin LIAO
  • DOUBLE ENGINEERED HIV-1 ENVELOPES
    Publication number: 20180036400
    Abstract: In certain aspects the invention provides HIV-1 engineered envelope proteins and their uses. The engineered envelopes comprise a sequence that prevents cleavage of the envelope associated with recombinant expression in a cell line, and N-terminal deletion which improves envelope expression as a monomer.
    Type: Application
    Filed: June 25, 2015
    Publication date: February 8, 2018
    Inventors: Barton F Haynes, Hua-Xin Liao, S. Munir Alam
  • Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies
    Patent number: 9717789
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: August 1, 2017
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • LIPOSOME-PEPTIDE CONJUGATE AND METHOD OF USING SAME TO INDUCE PRODUCTION OF ANTI-HIV ANTIBODIES
    Publication number: 20170106080
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: June 28, 2016
    Publication date: April 20, 2017
    Inventors: Barton F. HAYNES, S. Munir ALAM, Hua-Xin LIAO
  • MPER-LIPOSOME CONJUGATES AND USES THEREOF
    Publication number: 20170014503
    Abstract: The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 19, 2017
    Inventors: Barton F. HAYNES, Bette T. KORBER, S. Munir ALAM
  • METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
    Publication number: 20160271244
    Abstract: The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
    Type: Application
    Filed: February 29, 2016
    Publication date: September 22, 2016
    Inventors: Barton F. Haynes, Hua-Xin Liao, Georgia Tomaras, Thomas B. Kepler, Kwan-Ki Hwang, S. Munir Alam, Yang Liu, T. Matt Holl, Guang Yang, Garnett Kelsoe, Mattia Bonsignori
  • Methods for the induction of broadly anti-HIV-1 neutralizing antibody responses employing liposome-MPER peptide compositions
    Patent number: 9402917
    Abstract: The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: August 2, 2016
    Assignee: DUKE UNIVERSITY
    Inventors: S. Munir Alam, Barton F. Haynes, Moses D. Sekaran, Georgia Tomaras, Xiaoying Shen
  • Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies
    Patent number: 9402893
    Abstract: The present invention relates to a method of inducing the production of anti-HIV antibodies. The method comprises administering at least one liposome-peptide conjugate, wherein the peptide comprises a membrane proximal external region (MPER) epitope.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: August 2, 2016
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • SYNTHETIC ENV PROTEINS
    Publication number: 20150283227
    Abstract: The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1), and, in particular to a vaccine for HIV-1 and to methods of making and using same. The present invention provides synthetic glycosylated HIV-1 peptides, method for their preparation and use.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 8, 2015
    Inventors: Barton F. Haynes, Hua-Xin Liao, S. Munir Alam, Samuel Danishefsky, Baptiste Aussedat, Peter K. Park, Yusuf Vohra, Joseph Sodroski
  • METHOD OF INDUCING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS INVOLVING THE ADMINISTRATION OF MPER PEPTIDE-LIPOSOME CONJUGATES
    Publication number: 20150147387
    Abstract: The present invention relates to a method of inducing the production in a patient of anti-HIV antibodies. The method comprises administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect that induction. The peptide comprises a membrane external proximal region (MPER) epitope and the liposome comprises lysophosphorylcholine or phosphatidylserine.
    Type: Application
    Filed: February 3, 2015
    Publication date: May 28, 2015
    Inventors: Barton F. HAYNES, S. Munir Alam, Hua-Xin Liao
  • Method of inducing antibodies to human immunodeficiency virus involving the administration of MPER peptide-liposome conjugates
    Patent number: 8956627
    Abstract: The present invention relates to a method of inducing the production in a patient of anti-HIV antibodies. The method comprises administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect that induction. The peptide comprises a membrane external proximal region (MPER) epitope and the liposome comprises lysophosphorylcholine or phosphatidylserine.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: February 17, 2015
    Assignee: Duke University
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • METHOD OF INDUCING NEUTRALIZING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS
    Publication number: 20140322262
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: April 9, 2012
    Publication date: October 30, 2014
    Inventors: Leonard D. Spicer, Patrick N. Reardon, Barton F. Haynes, S. Munir Alam
  • METHOD OF INDUCING NEUTRALIZING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS
    Publication number: 20130323299
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: April 22, 2013
    Publication date: December 5, 2013
    Inventors: Barton F. HAYNES, S. Munir Alam, Hua-Xin Liao
  • METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
    Publication number: 20120321699
    Abstract: The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
    Type: Application
    Filed: February 25, 2011
    Publication date: December 20, 2012
    Inventors: Barton F. Haynes, Hua-Xin Liao, Georgia Tomaras, Thomas B. Kepler, Kwan-Ki Hwang, S.Munir Alam, Yang Liu, T. Matt Holl, Guang Yang, Garnett Kelsoe, Mattia Bonsignori
  • Method of inducing neutralizing antibodies to human immunodeficiency virus
    Publication number: 20120183597
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: October 4, 2011
    Publication date: July 19, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • FORMULATION
    Publication number: 20120177721
    Abstract: The present invention relates, in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies and, in particular, to a formulation comprising a prehairpin intermediate form of HIV-1 envelope gp41 linked to a liposome. The invention also relates to methods of inducing broadly neutralizing anti-HIV-1 antibodies using such a formulation.
    Type: Application
    Filed: April 5, 2010
    Publication date: July 12, 2012
    Inventors: S. Munir Alam, Barton F. Haynes, Stephen Harrison, Bing Chen
  • FORMULATION FOR INDUCING BROADLY REACTIVE NEUTRALIZING ANTI-HIV ANTIBODIES
    Publication number: 20120128758
    Abstract: The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.
    Type: Application
    Filed: April 5, 2010
    Publication date: May 24, 2012
    Inventors: S. Munir Alam, Barton F. Haynes, Moses D. Sekaran, Georgia Tomaras, Xiaoying Shen