Patents by Inventor Sabine Geisse

Sabine Geisse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized expression cassette for expressing a polypeptide with high yield
    Patent number: 11230718
    Abstract: The present invention is based on the finding that the combination of a specific 5?UTR polynucleotide sequence (see SEQ ID NO 1) and the hCD33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: January 25, 2022
    Assignee: Novartis AG
    Inventors: Zorica Dragic, Sabine Geisse, Rita Schmitz, Burkhard Wilms
  • OPTIMIZED EXPRESSION CASSETTE FOR EXPRESSING A POLYPEPTIDE WITH HIGH YIELD
    Publication number: 20170356006
    Abstract: The present invention is based on the finding that the combination of a specific 5?UTR polynucleotide sequence (see SEQ ID NO 1) and the hCD33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield.
    Type: Application
    Filed: April 21, 2017
    Publication date: December 14, 2017
    Applicant: NOVARTIS AG
    Inventors: Zorica DRAGIC, Sabine GEISSE, Rita SCHMITZ, Burkhard WILMS
  • Optimized expression cassette for expressing a polypeptide with high yield
    Patent number: 9663797
    Abstract: The present invention is based on the finding that the combination of a specific 5?UTR polynucleotide sequence (see SEQ ID NO 1) and the hCD33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: May 30, 2017
    Assignee: NOVARTIS AG
    Inventors: Zorica Dragic, Sabine Geisse, Rita Schmitz, Burkhard Wilms
  • OPTIMIZED EXPRESSION CASSETTE FOR EXPRESSING A POLYPEPTIDE WITH HIGH YIELD
    Publication number: 20160186206
    Abstract: The present invention is based on the finding that the combination of a specific 5?UTR polynucleotide sequence (see SEQ ID NO 1) and the hCD33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield.
    Type: Application
    Filed: November 18, 2013
    Publication date: June 30, 2016
    Inventors: Zorica DRAGIC, Sabine GEISSE, Rita SCHMITZ, Burkhard WILMS
  • Method of identifying ligands for nuclear receptors
    Publication number: 20050176062
    Abstract: The present invention provides a method of identifying a ligand to a nuclear receptor protein comprising wherein said nuclear receptor protein is first expressed in an eukaryotic expression system in the presence of at least one candidate ligand. The nuclear receptor protein is then purified, isolated and mass spectrometry is used to determine the presence of a bound ligand. The ligand is finally isolated and the measured spectra is compared with the spectra of known ligands in compound libraries to identify the ligand.
    Type: Application
    Filed: April 28, 2003
    Publication date: August 11, 2005
    Inventors: Reiner Aichholz, Francis Bitsch, Sabine Geisse, Jean-Marc Schlaeppi