Abstract: A suction tip that sucks a biological subject includes a base tip and a sub-tip. The base tip includes a distal end portion having a distal end opening, and a tubular passage connected to the distal end opening. The sub-tip includes a suction port that sucks the biological subject, and a guide passage having one end connected to the suction port and the other end that receives the distal end portion of the base tip. The base tip and the sub-tip are coupled and integrated by externally fitting the other end of the guide passage to the distal end portion, the integration forming one suction path in which the tubular passage and the guide passage communicate with each other. The suction port has a size smaller than a size of the distal end opening.

Abstract: Antibodies that bind to ?v?8 are provided.

Abstract: Antibodies that bind to ???8 are provided.

Abstract: The cell handling device includes a container having a section to store cells; a cell detection unit for detecting a cell stored in the section; a head device for conducting picking of cells, and transfer and release of the picked cells; a control unit; and a determination unit for making a determination of a cell state including at least one of the number, properties, and arrangement of the cells based on a detection result of the cell detection unit. The control unit causes the head device to execute, according to a state determination result obtained by the determination unit, one operation selected from among operation of picking all the cells stored in the section, operation of picking a part of the cells stored in the section, operation of picking a new cell and releasing the cell in the section, and operation of terminating processing of the section.

Abstract: A cell transfer apparatus transfers cells from a dish in which the cells are held to a microplate where a plurality of wells are classified into a plurality of groups. The cell transfer apparatus includes a camera unit that captures an image of the dish with the cells being held in the dish, an evaluation unit that gives evaluation levels to the plurality of cells held in the dish, respectively, based on the image of the dish with reference to predetermined multiple-step evaluation level for the cells, an allocation processor that sets transfer destinations of the cells on the dish so that the cells equal in evaluation level are distributed evenly to the groups in the microplate, and a shaft controller that transfers the cells in accordance with the transfer destinations set by the allocation processor.

Abstract: Antibodies that bind to ?v?8 are provided.

Abstract: A cell transfer device includes a base on which a container accommodating a plurality of cells is mounted, a head with a suction tip attached that sucks the cells in the container, and a control unit that controls the head. The cells are placed on a placement surface that is an upper surface of an underlying culture medium layer including a gel-like culture medium. The control unit acquires information on a height position of the placement surface, specifies a suction height for the cells existing at a first point on the placement surface, and causes the suction tip to suck the cells. Then, the control unit causes the suction tip to suck the cells existing at a second point different from the first point on the placement surface by using the suction height of the first point.

Abstract: There are prepared a first container which stores a liquid containing a cellular aggregate, a second container which receives a cellular aggregate, and a third container which stores a preliminary treatment solution, and a cylinder tip. The cylinder tip is formed with a syringe including a tubular passage having a front end opening which sucks the cellular aggregate, and a plunger which reciprocates in a tubular passage. Before sucking the cellular aggregate from the first container and discharging the same to the third container, the preliminary treatment solution is retained in a space between the tubular passage and the plunger by dipping the front end opening of the cylinder tip into the preliminary treatment solution in the third container and causing the plunger to reciprocate.

Abstract: The cell handling device includes a container having a section to store cells; a cell detection unit for detecting a cell stored in the section; a head device for conducting picking of cells, and transfer and release of the picked cells; a control unit; and a determination unit for making a determination of a cell state including at least one of the number, properties, and arrangement of the cells based on a detection result of the cell detection unit. The control unit causes the head device to execute, according to a state determination result obtained by the determination unit, one operation selected from among operation of picking all the cells stored in the section, operation of picking a part of the cells stored in the section, operation of picking a new cell and releasing the cell in the section, and operation of terminating processing of the section.

Abstract: A cell transfer apparatus includes a controller that controls generation of a suction force and a discharge force at a plurality of heads and controls movement of a head unit. The controller executes a process for specifying first and second specimen heads to be used for transferring the first and second specimens, a process for specifying first and second specimen wells to be used for receiving the first and second specimens, a process for sequentially sucking the cell of the first specimen from the first dish by the first tip attached to the first specimen head and then the cell of the second specimen from the second dish by the second tip, and a process for discharging the cell of the first specimen from the first tip to the first specimen well and the cell of the second specimen from the second tip to the second specimen well.

Abstract: A head device for mounting a dispensing tip includes a piston member, a first shaft member to move the piston member in an up-down direction, a tubular rod including a tubular space having a cylinder space in which the piston member is housed to move in the up-down direction and including a tip mounting portion into which a base end portion of the dispensing tip is fitted, a first frame equipped with the first shaft member and the tubular rod, a second shaft member engaging with the first frame to move the first frame, a second frame equipped with the second shaft member and including a guide portion configured to guide movement of the tubular rod in the up-down direction in association with the movement of the first frame in the up-down direction, and a shaft controller configured to control operation of the first and second shaft members.

Abstract: A cell transfer apparatus transfers cells from a dish in which the cells are held to a microplate where a plurality of wells are classified into a plurality of groups. The cell transfer apparatus includes a camera unit that captures an image of the dish with the cells being held in the dish, an evaluation unit that gives evaluation levels to the plurality of cells held in the dish, respectively, based on the image of the dish with reference to predetermined multiple-step evaluation level for the cells, an allocation processor that sets transfer destinations of the cells on the dish so that the cells equal in evaluation level are distributed evenly to the groups in the microplate, and a shaft controller that transfers the cells in accordance with the transfer destinations set by the allocation processor.

Abstract: An aspiration tip is provided with: a syringe section including an inner tubular passage defining an aspiration path for aspirating an object; and a plunger movable in the tubular passage while coming in contact with an inner wall surface of the tubular passage. The syringe section includes an aspiration opening formed in a distal end of the tubular passage for aspirating the object, and the plunger includes a plunger leading end portion configured to protrude from the aspiration opening before the aspiration of the object and at the time of discharge of the object, and retract in the syringe section at the time of the aspiration of the object.

Abstract: An object-holding device includes a container, a plate, and a dispersing mechanism. The container is configured to store a liquid, and includes an upper opening for charging an object into the stored liquid, and a bottom wall. The plate has an upper surface and a lower surface and is immersed into the liquid in a state in which the lower surface is spaced away from the bottom wall of the container, with this plate including: one or a plurality of holding portions arranged on the upper surface side and configured to carry the object; and a through hole passing through the holding portion from the upper surface to the lower surface. The dispersing mechanism is configured to form, in the through hole, a liquid flow which flows from the lower surface side toward the upper surface side to raise the object carried on the holding portion.

Abstract: An object-holding device includes a container, a plate, and a dispersing mechanism. The container is configured to store a liquid, and includes an upper opening for charging an object into the stored liquid, and a bottom wall. The plate has an upper surface and a lower surface and is immersed into the liquid in a state in which the lower surface is spaced away from the bottom wall of the container, with this plate including: one or a plurality of holding portions arranged on the upper surface side and configured to carry the object; and a through hole passing through the holding portion from the upper surface to the lower surface. The dispersing mechanism is configured to form, in the through hole, a liquid flow which flows from the lower surface side toward the upper surface side to raise the object carried on the holding portion.

Abstract: There are prepared a first container which stores a liquid containing a cellular aggregate, a second container which receives a cellular aggregate, and a third container which stores a preliminary treatment solution, and a cylinder tip. The cylinder tip is formed with a syringe including a tubular passage having a front end opening which sucks the cellular aggregate, and a plunger which reciprocates in a tubular passage. Before sucking the cellular aggregate from the first container and discharging the same to the third container, the preliminary treatment solution is retained in a space between the tubular passage and the plunger by dipping the front end opening of the cylinder tip into the preliminary treatment solution in the third container and causing the plunger to reciprocate.

Abstract: An object moving device includes: a first drive mechanism configured to move a head unit in a first direction and in a second direction; a second drive mechanism configured to move an illumination unit in the first direction; and a third drive mechanism configured to move a camera unit in the first direction. A control unit controls the first drive mechanism to move the head unit on a first path. The control unit controls the second and third drive mechanisms to move the illumination unit and the camera unit on the first path between the first container and the second container. When the head unit and the illumination unit interfere with each other on the first path, the control unit implements control such that the head unit moves in the second direction and the head units moves in the first direction on a second path parallel to the first path.